#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12498932|imex:IM-25478-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	-	-	figure legend:Table 1; 38-40|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	sufficient binding region:782-935	sufficient binding region:591-960	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GLM3	uniprotkb:Q92834-2	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	intact:EBI-6558503|ensembl:ENSP00000493468	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:q92834-2(display_long)|uniprotkb:RPGR(gene name)|psi-mi:RPGR(display_short)|uniprotkb:RP3(gene name synonym)|uniprotkb:XLRP3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12498985|imex:IM-25478-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	uniprotkb:Q92834(isoform-parent)|ensembl:ENSG00000156313(gene)|ensembl:ENST00000642395(transcript)|intact:EBI-6558417(isoform-parent)|uniprotkb:Q92834-2(isoform-parent)	-	-	-	figure legend:Table 1; 3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/04	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rogid:35Fpoir3fSKBCF3H+Fm9Ll4sNQE9606	rigid:W1USeu8IRthLpdBdugRJ8ba+MeE	false	sufficient binding region:842..842-1221	sufficient binding region:1-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GLM3	uniprotkb:Q92834-2	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	intact:EBI-6558503|ensembl:ENSP00000493468	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:q92834-2(display_long)|uniprotkb:RPGR(gene name)|psi-mi:RPGR(display_short)|uniprotkb:RP3(gene name synonym)|uniprotkb:XLRP3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12498994|imex:IM-25478-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	uniprotkb:Q92834(isoform-parent)|ensembl:ENSG00000156313(gene)|ensembl:ENST00000642395(transcript)|intact:EBI-6558417(isoform-parent)|uniprotkb:Q92834-2(isoform-parent)	-	-	-	figure legend:Table 1; 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/04	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rogid:35Fpoir3fSKBCF3H+Fm9Ll4sNQE9606	rigid:W1USeu8IRthLpdBdugRJ8ba+MeE	false	sufficient binding region:842..842-1221	sufficient binding region:1-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:E1BJB5	uniprotkb:Q9GLM3	intact:EBI-11784354|ensembl:ENSBTAP00000042828|intact:EBI-12498969	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	psi-mi:e1bjb5_bovin(display_long)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499256|imex:IM-25478-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008126(gene)|ensembl:ENSBTAT00000045440(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016604"(nuclear body)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097470"(ribbon synapse)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0120206"(photoreceptor distal connecting cilium)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904491"(protein localization to ciliary transition zone)|interpro:IPR029775	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	-	-	-	figure legend:Table 1; 19 and 20|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2019/04/15	rogid:8vqJ2Q28pTxpvFXtK52eEdAupNc9913	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rigid:AOPHS4Do9Bh/7Bm+uZN3yt5PKow	false	-	sufficient binding region:731..731-867..867	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75161-1	uniprotkb:Q9GLM3	intact:EBI-12499345|ensembl:ENSP00000367398	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499264|imex:IM-25478-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	-	-	-	figure legend:Table 1; 27|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rigid:l5syV7mlw3E2aXcXJyAdtXn+8c4	false	sufficient binding region:484-982	sufficient binding region:554..554-867..867	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499276|imex:IM-25478-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	comment:mutation arg852gln has no significant effect on association	comment:mutations arg740his and arg848trp have no significant effect on association	figure legend:Table 1; 28 and Table 2; 8,9, 10, 12 and 13, fig. 5B and D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	mutation with no effect:852-852|sufficient binding region:587-935|necessary binding region:890-935|mutation disrupting interaction:746-746|mutation disrupting interaction:876-876	sufficient binding region:484-982|mutation disrupting interaction:754-754|necessary binding region:779-982	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75161-1	uniprotkb:Q9GLM3	intact:EBI-12499345|ensembl:ENSP00000367398	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499289|imex:IM-25478-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	-	-	-	figure legend:Table 1; 29-31|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rigid:l5syV7mlw3E2aXcXJyAdtXn+8c4	false	sufficient binding region:591-960	sufficient binding region:731..731-867..867	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75161-1	uniprotkb:Q68CZ1-1	intact:EBI-12499345|ensembl:ENSP00000367398	intact:EBI-12499326|ensembl:ENSP00000493946	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:q68cz1-1(display_long)|uniprotkb:Nephrocystin-8(gene name synonym)|uniprotkb:RPGR-interacting protein 1-like protein(gene name synonym)|uniprotkb:RPGRIP1L(gene name)|psi-mi:RPGRIP1L(display_short)|uniprotkb:FTM(gene name synonym)|uniprotkb:KIAA1005(gene name synonym)|uniprotkb:NPHP8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499317|imex:IM-25478-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	intact:EBI-5235485(isoform-parent)|ensembl:ENSG00000103494(gene)|ensembl:ENST00000647211(transcript)	-	-	-	figure legend:Table 1; 48|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rogid:A1URXcmr5UTNl+5Vov572mFBpdI9606	rigid:5h0Owr3Jzd6cxrgW28IKjTLgADo	false	sufficient binding region:484-982	sufficient binding region:771-926	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75161-1	uniprotkb:Q68CZ1-1	intact:EBI-12499345|ensembl:ENSP00000367398	intact:EBI-12499326|ensembl:ENSP00000493946	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:q68cz1-1(display_long)|uniprotkb:Nephrocystin-8(gene name synonym)|uniprotkb:RPGR-interacting protein 1-like protein(gene name synonym)|uniprotkb:RPGRIP1L(gene name)|psi-mi:RPGRIP1L(display_short)|uniprotkb:FTM(gene name synonym)|uniprotkb:KIAA1005(gene name synonym)|uniprotkb:NPHP8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499356|imex:IM-25478-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	intact:EBI-5235485(isoform-parent)|ensembl:ENSG00000103494(gene)|ensembl:ENST00000647211(transcript)	-	-	-	figure legend:Table 1; 47|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2016/08/05	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rogid:A1URXcmr5UTNl+5Vov572mFBpdI9606	rigid:5h0Owr3Jzd6cxrgW28IKjTLgADo	false	sufficient binding region:484-982	sufficient binding region:771-926	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:E1BJB5	uniprotkb:Q9GLM3	intact:EBI-11784354|ensembl:ENSBTAP00000042828|intact:EBI-12498969	intact:EBI-12498949|uniprotkb:Q9GLJ5|uniprotkb:Q9GLJ6|uniprotkb:Q9GLJ7	psi-mi:e1bjb5_bovin(display_long)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)	psi-mi:rpgr1_bovin(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:"MI:0018"(two hybrid)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12498966|imex:IM-25478-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008126(gene)|ensembl:ENSBTAT00000045440(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016604"(nuclear body)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097470"(ribbon synapse)|go:"GO:0097546"(ciliary base)|go:"GO:0097730"(non-motile cilium)|go:"GO:0120206"(photoreceptor distal connecting cilium)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1904491"(protein localization to ciliary transition zone)|interpro:IPR029775	go:"GO:0007601"(visual perception)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0050896"(response to stimulus)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR041091|refseq:NP_851377.1|interpro:IPR021656|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031134|interpro:IPR031139|interpro:IPR035892	-	-	-	figure legend:no figure|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/08/04	2019/04/15	rogid:8vqJ2Q28pTxpvFXtK52eEdAupNc9913	rogid:L3GmGIbtNpcrk+yb0OSZaYrbcpQ9913	rigid:AOPHS4Do9Bh/7Bm+uZN3yt5PKow	false	-	sufficient binding region:554..554-867..867	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499416|imex:IM-25478-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	-	-	figure legend:2B and supplementary 9B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	flag tag:n-n|sufficient binding region:587-935	ha tag:n-n|sufficient binding region:484-982	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499434|imex:IM-25478-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	-	-	figure legend:2C and supplementary 9A|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	flag tag:n-n|sufficient binding region:587-935	ha tag:n-n|sufficient binding region:484-982	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12501485|imex:IM-25478-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	comment:mutation arg852gln has no effect on association	comment:mutant arg740his has no effect on association	figure legend:5E|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2016/08/04	2016/08/09	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	flag tag:n-n|sufficient binding region:611-1286|mutation decreasing interaction:876-876|necessary binding region:890-1236|mutation with no effect:852-852	ha tag:n-n|mutation disrupting interaction:754-754|necessary binding region:779-1426	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499514|imex:IM-25478-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:3H|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	sufficient binding region:611-1286|cYFP:n-n	enhanced yellow fluorescent protein tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499540|imex:IM-25478-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:supplemental 10 H,L and P|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	sufficient binding region:611-1286|red fluorescent protein tag:n-n	cYFP:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0096"(pull down)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499561|imex:IM-25478-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	-	-	figure legend:supplemental 8B|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	glutathione s tranferase tag:n-n|sufficient binding region:782-935	flag tag:n-n|sufficient binding region:591-1093	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96KN7-1	uniprotkb:O75161-1	intact:EBI-12499377|ensembl:ENSP00000382895	intact:EBI-12499345|ensembl:ENSP00000367398	psi-mi:q96kn7-1(display_long)|uniprotkb:RPGRIP1(gene name)|psi-mi:RPGRIP1(display_short)	psi-mi:o75161-1(display_long)|uniprotkb:Nephroretinin(gene name synonym)|uniprotkb:NPHP4(gene name)|psi-mi:NPHP4(display_short)|uniprotkb:KIAA0673(gene name synonym)	psi-mi:"MI:0096"(pull down)	Roepman et al. (2005)	pubmed:16339905|imex:IM-25478	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12499603|imex:IM-25478-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092200(gene)|ensembl:ENST00000400017(transcript)|intact:EBI-1050213(isoform-parent)	intact:EBI-4281852(isoform-parent)|ensembl:ENSG00000131697(gene)|ensembl:ENST00000378156(transcript)	-	-	-	figure legend:supplemental 8D|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/08/04	2016/08/05	rogid:kPKjJC4b+zX86SnkVPoLyq7/SYA9606	rogid:oQi0NY0QgJtrAUUHvnob6BEKcIs9606	rigid:Jy5X00BMfeIsVqzsi7xludJabOM	false	flag tag:n-n|sufficient binding region:782-935	sufficient binding region:591-1093|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)