#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
matrixdb:MULT_53_VAR3_human	uniprotkb:P05067-PRO_0000000093	intact:EBI-11682400	intact:EBI-2431589|intact:EBI-20772365	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689006|imex:IM-24975-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	chain-seq-start:672|chain-seq-end:711	figure legend:Figure 1A|comment:"The experiment was performed with (Abeta1–40) fibrils"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2016/04/22	-	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	-	false	his tag:c-c|sufficient binding region:113-580|myc tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_53_VAR3_human	uniprotkb:P05067-PRO_0000000093	intact:EBI-11682400	intact:EBI-2431589|intact:EBI-20772365	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689047|imex:IM-24975-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	chain-seq-start:672|chain-seq-end:711	figure legend:Figure 1C and 4B|comment:"The experiment was performed with (Abeta1–40) fibrils"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2016/04/22	-	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	-	false	his tag:c-c|sufficient binding region:113-580|myc tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_53_VAR3_human	uniprotkb:P05067-PRO_0000000092	intact:EBI-11682400	intact:EBI-821758	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689107|imex:IM-24975-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	chain-seq-start:672|chain-seq-end:713	figure legend:Figure 4C|comment:"The experiment was performed with (Abeta1–42) fibrils"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2017/03/06	-	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	-	false	his tag:c-c|sufficient binding region:113-580|myc tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:76023"	matrixdb:MULT_53_VAR3_human	intact:EBI-8805500	intact:EBI-11682400	psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long)	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:"MI:0892"(solid phase assay)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689107|imex:IM-24975-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	-	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	figure legend:Figure 4C|comment:"The experiment was performed with (Abeta1–42) fibrils"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2017/03/06	-	-	-	false	-	his tag:c-c|sufficient binding region:113-580|myc tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
matrixdb:MULT_53_VAR3_human	uniprotkb:P05067-PRO_0000000093	intact:EBI-11682400	intact:EBI-2431589|intact:EBI-20772365	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689128|imex:IM-24975-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	intact:EBI-77613(chain-parent)	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	chain-seq-start:672|chain-seq-end:711	figure legend:Figures 3A and 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2016/04/27	-	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	-	false	myc tag:c-c|his tag:c-c|sufficient binding region:113-580	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:76023"	matrixdb:MULT_53_VAR3_human	intact:EBI-8805500	intact:EBI-11682400	psi-mi:tht(display_short)|psi-mi:"CHEBI:76023"(display_long)	psi-mi:collagen-xxv-3_human(display_short)|psi-mi:MULT_53_VAR3_human(display_long)|intact:Collagen type XXV trimer, variant 3(complex recommended name)|intact:Type XXV collagen(complex synonym)|intact:COL25A1 trimer(complex systematic name)	psi-mi:"MI:0051"(fluorescence technology)	Söderberg et al. (2005)	imex:IM-24975|pubmed:15853808	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-11689128|imex:IM-24975-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	pubmed:1916105(see-also)|pubmed:17876790(see-also)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:1990327"(collagen type XXV trimer)|go:"GO:0008201"(heparin binding)|go:"GO:0001540"(amyloid-beta binding)|evidence ontology:"ECO:0005547"|complex portal:CPX-391(complex-primary)	-	-	curated-complex:Type II orientated transmembrane collagen. Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.|complex-assembly:Homotrimer|complex-properties:Triple-helices consisting of about 1000 amino acids per chain forming a coiled coil structure. Each polypeptide forms a left-handed helix in which every third residue, glycine, comes into the centre of the superhelix.|curation request:Sylvie Ricard-Blum, MatrixDB	figure legend:Figures 3A and 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/01/19	2016/04/27	-	-	-	false	-	myc tag:c-c|his tag:c-c|sufficient binding region:113-580	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)