#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q86VF7 uniprotkb:P50461 intact:EBI-5660292|uniprotkb:Q86TC5|uniprotkb:Q86VF6|uniprotkb:Q719H6|uniprotkb:Q6PDB0|uniprotkb:Q8N8F9|uniprotkb:Q8N3R6|uniprotkb:Q96MG4|uniprotkb:Q6N059|uniprotkb:Q86TD6|uniprotkb:Q8TCH0|uniprotkb:Q5VWI4|uniprotkb:Q86TE6|uniprotkb:Q6N026|uniprotkb:Q5VWI3|uniprotkb:O15500|uniprotkb:Q6NSH8|uniprotkb:Q6MZK3|ensembl:ENSP00000353078 intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388 psi-mi:nrap_human(display_long)|uniprotkb:NRAP(gene name)|psi-mi:NRAP(display_short) psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short) psi-mi:"MI:0049"(filter binding) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12504460|imex:IM-25495-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006166.3|refseq:NP_932326.2|refseq:NP_001248392.1|ensembl:ENSG00000197893(gene)|ensembl:ENST00000359988(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0071691"(cardiac muscle thin filament assembly)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR013998(Nebulin) refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13 omim:612124(see-also) - - figure legend:3a and b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:B8gGc3ZBL+ibTS7bsszXBX3MTH09606 rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606 rigid:vIAsLQKEIEQcvnVqUgqTqemyBLU false t7 tag:n-n|sufficient binding region:1-121 eef tag:c-c|mutation disrupting interaction:58-58 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P50461 uniprotkb:P35609 intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short) psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:"MI:0049"(filter binding) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12504476|imex:IM-25495-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13 refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N - - - figure legend:3a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rigid:2Sht06CpeqyO65DfgWv59niod14 false eef tag:c-c t7 tag:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86VF7 uniprotkb:P35609 intact:EBI-5660292|uniprotkb:Q86TC5|uniprotkb:Q86VF6|uniprotkb:Q719H6|uniprotkb:Q6PDB0|uniprotkb:Q8N8F9|uniprotkb:Q8N3R6|uniprotkb:Q96MG4|uniprotkb:Q6N059|uniprotkb:Q86TD6|uniprotkb:Q8TCH0|uniprotkb:Q5VWI4|uniprotkb:Q86TE6|uniprotkb:Q6N026|uniprotkb:Q5VWI3|uniprotkb:O15500|uniprotkb:Q6NSH8|uniprotkb:Q6MZK3|ensembl:ENSP00000353078 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 psi-mi:nrap_human(display_long)|uniprotkb:NRAP(gene name)|psi-mi:NRAP(display_short) psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:"MI:0049"(filter binding) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12504488|imex:IM-25495-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006166.3|refseq:NP_932326.2|refseq:NP_001248392.1|ensembl:ENSG00000197893(gene)|ensembl:ENST00000359988(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0071691"(cardiac muscle thin filament assembly)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR013998(Nebulin) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N - - - figure legend:3a|comment:actinin 2 was detected by a monoclonal antibody to actinin 2, not by an antibody to the T7 tag.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:B8gGc3ZBL+ibTS7bsszXBX3MTH09606 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rigid:V1ookiNDCZfrrrqQkjWIaLB5+yg false t7 tag:n-n|sufficient binding region:1-121 t7 tag:n-n - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q86VF7 uniprotkb:P50461 intact:EBI-5660292|uniprotkb:Q86TC5|uniprotkb:Q86VF6|uniprotkb:Q719H6|uniprotkb:Q6PDB0|uniprotkb:Q8N8F9|uniprotkb:Q8N3R6|uniprotkb:Q96MG4|uniprotkb:Q6N059|uniprotkb:Q86TD6|uniprotkb:Q8TCH0|uniprotkb:Q5VWI4|uniprotkb:Q86TE6|uniprotkb:Q6N026|uniprotkb:Q5VWI3|uniprotkb:O15500|uniprotkb:Q6NSH8|uniprotkb:Q6MZK3|ensembl:ENSP00000353078 intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388 psi-mi:nrap_human(display_long)|uniprotkb:NRAP(gene name)|psi-mi:NRAP(display_short) psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short) psi-mi:"MI:0049"(filter binding) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-12504517|imex:IM-25495-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006166.3|refseq:NP_932326.2|refseq:NP_001248392.1|ensembl:ENSG00000197893(gene)|ensembl:ENST00000359988(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0071691"(cardiac muscle thin filament assembly)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR013998(Nebulin) refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13 omim:612124(see-also) - - figure legend:3b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:B8gGc3ZBL+ibTS7bsszXBX3MTH09606 rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606 rigid:vIAsLQKEIEQcvnVqUgqTqemyBLU false t7 tag:n-n|sufficient binding region:1-183 eef tag:c-c|mutation decreasing interaction:58-58 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P35609 uniprotkb:P50461 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12504544|imex:IM-25495-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13 - - - figure legend:4a and b|comment:Neither CRP3/MLP mutant cys58gly nor increased concentrations of the protein change the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606 rigid:AfQc999W7imjb4LBVceSL0OgjUw false t7 tag:n-n eef tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P35609 uniprotkb:Q86VF7 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-5660292|uniprotkb:Q86TC5|uniprotkb:Q86VF6|uniprotkb:Q719H6|uniprotkb:Q6PDB0|uniprotkb:Q8N8F9|uniprotkb:Q8N3R6|uniprotkb:Q96MG4|uniprotkb:Q6N059|uniprotkb:Q86TD6|uniprotkb:Q8TCH0|uniprotkb:Q5VWI4|uniprotkb:Q86TE6|uniprotkb:Q6N026|uniprotkb:Q5VWI3|uniprotkb:O15500|uniprotkb:Q6NSH8|uniprotkb:Q6MZK3|ensembl:ENSP00000353078 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:nrap_human(display_long)|uniprotkb:NRAP(gene name)|psi-mi:NRAP(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-12504544|imex:IM-25495-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_006166.3|refseq:NP_932326.2|refseq:NP_001248392.1|ensembl:ENSG00000197893(gene)|ensembl:ENST00000359988(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0071691"(cardiac muscle thin filament assembly)|interpro:IPR000900(Nebulin 35 residue motif)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR013998(Nebulin) - - - figure legend:4a and b|comment:Neither CRP3/MLP mutant cys58gly nor increased concentrations of the protein change the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:B8gGc3ZBL+ibTS7bsszXBX3MTH09606 rigid:AfQc999W7imjb4LBVceSL0OgjUw false t7 tag:n-n t7 tag:n-n|sufficient binding region:1-183 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P35609 uniprotkb:P50461 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-5658719|uniprotkb:Q9P131|intact:EBI-9540516|uniprotkb:S4S7M7|ensembl:ENSP00000265968|ensembl:ENSP00000431813|ensembl:ENSP00000497388 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:csrp3_human(display_long)|uniprotkb:CLP(gene name synonym)|uniprotkb:Cardiac LIM protein(gene name synonym)|uniprotkb:Cysteine-rich protein 3(gene name synonym)|uniprotkb:LIM domain protein, cardiac(gene name synonym)|uniprotkb:MLP(gene name synonym)|uniprotkb:Muscle LIM protein(gene name synonym)|uniprotkb:CSRP3(gene name)|psi-mi:CSRP3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gehmlich et al. (2004) pubmed:15205937|imex:IM-25495 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-12504557|imex:IM-25495-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_003467.1|ensembl:ENSG00000129170(gene)|ensembl:ENST00000265968(transcript)|ensembl:ENST00000533783(transcript)|ensembl:ENST00000649235(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031433"(telethonin binding)|go:"GO:0033292"(T-tubule organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060537"(muscle tissue development)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903920"(positive regulation of actin filament severing)|interpro:IPR001781(Zinc finger, LIM-type)|rcsb pdb:2O10|rcsb pdb:2O13 - - - figure legend:4a|comment:Neither CRP3/MLP mutant cys58gly nor increased concentrations of the protein change the association|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/08/11 2016/08/11 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:END0H7Mm0BQlKb0pQ3cEUoqXFmA9606 rigid:2Sht06CpeqyO65DfgWv59niod14 false t7 tag:n-n eef tag:c-c|mutation decreasing interaction:58-58 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)