#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96T91 uniprotkb:Q86YW7 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659720|uniprotkb:Q6NTD0|uniprotkb:Q8NFW2|ensembl:ENSP00000478993|ensembl:ENSP00000479431 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:gphb5_human(display_long)|uniprotkb:GPHB5(gene name)|psi-mi:GPHB5(display_short)|uniprotkb:GPB5(gene name synonym)|uniprotkb:ZLUT1(gene name synonym)|uniprotkb:Thyrostimulin subunit beta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659717|imex:IM-25056-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_660154.3|ensembl:ENSG00000179600(gene)|ensembl:ENST00000314140(transcript)|ensembl:ENST00000621500(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0005615"(extracellular space) - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:DbPi26mN9tn8PEIzQ/6ZWmyQsKQ9606 rigid:YuGsqIJ7MeyOV64mBelcC9mWiUQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DN86 uniprotkb:Q96T91 intact:EBI-8626304|uniprotkb:P01233|uniprotkb:Q8WXL1|uniprotkb:B9ZVP5|uniprotkb:A1A5E0|uniprotkb:Q8WXL2|intact:MINT-1510897|uniprotkb:Q3SY41|uniprotkb:Q3KPI3|uniprotkb:Q8WXL4|uniprotkb:Q14000|uniprotkb:Q8WTT5|uniprotkb:Q13991|uniprotkb:Q8WXL3|ensembl:ENSP00000301408|ensembl:ENSP00000349954|ensembl:ENSP00000403649 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 psi-mi:cgb3_human(display_long)|uniprotkb:CGB5(gene name)|psi-mi:CGB5(display_short)|uniprotkb:CGB8(gene name)|psi-mi:CGB8(display_short)|uniprotkb:CGB3(gene name)|psi-mi:CGB3(display_short)|uniprotkb:CGB(gene name synonym)|uniprotkb:Choriogonadotropin subunit beta(gene name synonym)|uniprotkb:Chorionic gonadotropin chain beta(gene name synonym) psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659740|imex:IM-25056-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_149032.1|refseq:NP_000728.1|refseq:NP_149439.1|ensembl:ENSG00000104827(gene)|ensembl:ENSG00000189052(gene)|ensembl:ENSG00000213030(gene)|ensembl:ENST00000301408(transcript)|ensembl:ENST00000357383(transcript)|ensembl:ENST00000448456(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007292"(female gamete generation)|go:"GO:0009755"(hormone-mediated signaling pathway)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|rcsb pdb:1HCN|rcsb pdb:1HRP|rcsb pdb:1QFW|rcsb pdb:1XUL|reactome:R-HSA-209822|reactome:R-HSA-8866910 refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 - comment:mint|function:Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy - figure legend:1B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/03/08 2016/03/18 rogid:Fg4f/QYLQ+ZjWmJ1xx/ZNXwdvi89606 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rigid:GpLqJv+ktL4sLNW8o+4wMza9ro0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96T91 uniprotkb:P01225 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-1030645|uniprotkb:Q14D61|uniprotkb:A2TF08|uniprotkb:A5JVV3|ensembl:ENSP00000254122|ensembl:ENSP00000416606|ensembl:ENSP00000433424 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:fshb_human(display_long)|uniprotkb:FSHB(gene name)|psi-mi:FSHB(display_short)|uniprotkb:Follicle-stimulating hormone beta subunit(gene name synonym)|uniprotkb:Follitropin beta chain(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659744|imex:IM-25056-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_000501.1|refseq:NP_001018090.1|ensembl:ENSG00000131808(gene)|ensembl:ENST00000254122(transcript)|ensembl:ENST00000417547(transcript)|ensembl:ENST00000533718(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010893"(positive regulation of steroid biosynthetic process)|go:"GO:0016913"(follicle-stimulating hormone activity)|go:"GO:0016914"(follicle-stimulating hormone complex)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060011"(Sertoli cell proliferation)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|rcsb pdb:1FL7|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-209822|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-35604N - - - figure legend:1B-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:59ws68aVD9u6NFa6/H6pXZpkgYU9606 rigid:j1J1cRRcH7MWpqBgX0R8b9K6k5Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96T91 uniprotkb:P01222 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659752|uniprotkb:B1AKP0|uniprotkb:Q16163|ensembl:ENSP00000256592 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:tshb_human(display_long)|uniprotkb:TSHB(gene name)|psi-mi:TSHB(display_short)|uniprotkb:Thyroid-stimulating hormone subunit beta(gene name synonym)|uniprotkb:Thyrotropin beta chain(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659748|imex:IM-25056-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_000540.2|refseq:NP_001264920.1|refseq:XP_011540367.1|ensembl:ENSG00000134200(gene)|ensembl:ENST00000256592(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0033189"(response to vitamin A)|go:"GO:0043627"(response to estrogen)|go:"GO:0051592"(response to calcium ion)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|reactome:R-HSA-209822|reactome:R-HSA-209968|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 - - - figure legend:1B-4|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:llHZPwtiNb4H5IIEwcyG7UGeyc89606 rigid:aY625DOp3ihq7Q0Y+KzSoQwNzXU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96T91 uniprotkb:P01229 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659791|uniprotkb:Q9UDI0|ensembl:ENSP00000497294 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:lshb_human(display_long)|uniprotkb:LHB(gene name)|psi-mi:LHB(display_short)|uniprotkb:Luteinizing hormone subunit beta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659786|imex:IM-25056-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_000885.1|ensembl:ENSG00000104826(gene)|ensembl:ENST00000649238(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006701"(progesterone biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008584"(male gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR018245|interpro:IPR029034|rcsb pdb:1M92|reactome:R-HSA-193048|reactome:R-HSA-193993|reactome:R-HSA-209822|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|reactome:R-HSA-975578 - - - figure legend:1B-5|comment:weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:U2YUIHO+qXqjFYhpTewcAZmZHUw9606 rigid:rhxVeLpxQSKK6sP+APiL6mKLwJc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96T91 uniprotkb:Q86YW7 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659720|uniprotkb:Q6NTD0|uniprotkb:Q8NFW2|ensembl:ENSP00000478993|ensembl:ENSP00000479431 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:gphb5_human(display_long)|uniprotkb:GPHB5(gene name)|psi-mi:GPHB5(display_short)|uniprotkb:GPB5(gene name synonym)|uniprotkb:ZLUT1(gene name synonym)|uniprotkb:Thyrostimulin subunit beta(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659827|imex:IM-25056-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_660154.3|ensembl:ENSG00000179600(gene)|ensembl:ENST00000314140(transcript)|ensembl:ENST00000621500(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0005615"(extracellular space) - - - figure legend:3 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:DbPi26mN9tn8PEIzQ/6ZWmyQsKQ9606 rigid:YuGsqIJ7MeyOV64mBelcC9mWiUQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96T91 uniprotkb:Q86YW7 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659720|uniprotkb:Q6NTD0|uniprotkb:Q8NFW2|ensembl:ENSP00000478993|ensembl:ENSP00000479431 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:gphb5_human(display_long)|uniprotkb:GPHB5(gene name)|psi-mi:GPHB5(display_short)|uniprotkb:GPB5(gene name synonym)|uniprotkb:ZLUT1(gene name synonym)|uniprotkb:Thyrostimulin subunit beta(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11659977|imex:IM-25056-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 refseq:NP_660154.3|ensembl:ENSG00000179600(gene)|ensembl:ENST00000314140(transcript)|ensembl:ENST00000621500(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0005615"(extracellular space) - - - figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/08 2016/03/18 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:DbPi26mN9tn8PEIzQ/6ZWmyQsKQ9606 rigid:YuGsqIJ7MeyOV64mBelcC9mWiUQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86YW7 uniprotkb:P21163 intact:EBI-11659720|uniprotkb:Q6NTD0|uniprotkb:Q8NFW2|ensembl:ENSP00000478993|ensembl:ENSP00000479431 intact:EBI-11659893 psi-mi:gphb5_human(display_long)|uniprotkb:GPHB5(gene name)|psi-mi:GPHB5(display_short)|uniprotkb:GPB5(gene name synonym)|uniprotkb:ZLUT1(gene name synonym)|uniprotkb:Thyrostimulin subunit beta(gene name synonym) psi-mi:pngf_elimr(display_long)|uniprotkb:ngl(gene name)|psi-mi:ngl(display_short)|uniprotkb:png(gene name synonym)|uniprotkb:Glycopeptide N-glycosidase(gene name synonym)|uniprotkb:N-glycanase(gene name synonym) psi-mi:"MI:2281"(deamidation assay) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:172045(elimr)|taxid:172045(elimr) psi-mi:"MI:2280"(deamidation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11659890|imex:IM-25056-13 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660154.3|ensembl:ENSG00000179600(gene)|ensembl:ENST00000314140(transcript)|ensembl:ENST00000621500(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001545(Gonadotropin, beta chain)|interpro:IPR006208(Cystine knot)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0005615"(extracellular space) rcsb pdb:1PGS|rcsb pdb:1PNF|rcsb pdb:1PNG|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR015197(Peptide-N-glycosidase F, C-terminal)|interpro:IPR015196(Peptide-N-glycosidase F, N terminal)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0016715"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen)|refseq:WP_034866261.1 go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity") - - figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/08 2017/08/08 rogid:DbPi26mN9tn8PEIzQ/6ZWmyQsKQ9606 rogid:HbXCebDQiwH4rJgO1zwKBd9GxfI172045 rigid:ONwxgVIK1gA6XgyegP3/EWX4Az8 false deamidated L-asparagine:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96T91 uniprotkb:P21163 intact:EBI-11659696|uniprotkb:Q52LE2|ensembl:ENSP00000279168|ensembl:ENSP00000432918 intact:EBI-11659893 psi-mi:gpha2_human(display_long)|uniprotkb:GPHA2(gene name)|psi-mi:GPHA2(display_short)|uniprotkb:GPA2(gene name synonym)|uniprotkb:ZSIG51(gene name synonym)|uniprotkb:Putative secreted protein Zsig51(gene name synonym)|uniprotkb:Thyrostimulin subunit alpha(gene name synonym) psi-mi:pngf_elimr(display_long)|uniprotkb:ngl(gene name)|psi-mi:ngl(display_short)|uniprotkb:png(gene name synonym)|uniprotkb:Glycopeptide N-glycosidase(gene name synonym)|uniprotkb:N-glycanase(gene name synonym) psi-mi:"MI:2281"(deamidation assay) Nakabayashi et al. (2002) imex:IM-25056|pubmed:12045258 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:172045(elimr)|taxid:172045(elimr) psi-mi:"MI:2280"(deamidation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11659970|imex:IM-25056-15 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570125.1|refseq:XP_011543077.1|refseq:XP_011543078.1|ensembl:ENSG00000149735(gene)|ensembl:ENST00000279168(transcript)|ensembl:ENST00000533257(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051427"(hormone receptor binding)|interpro:IPR000476(Glycoprotein hormone alpha chain)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR029034|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821 rcsb pdb:1PGS|rcsb pdb:1PNF|rcsb pdb:1PNG|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR015197(Peptide-N-glycosidase F, C-terminal)|interpro:IPR015196(Peptide-N-glycosidase F, N terminal)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0016715"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen)|refseq:WP_034866261.1 go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity") - - figure legend:3C-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/03/08 2017/08/08 rogid:E1bowfkTekQUIIbQHVJJPczqEm49606 rogid:HbXCebDQiwH4rJgO1zwKBd9GxfI172045 rigid:V3+IiQ9ELLiI1J8wynJ/VYCEcUU false deamidated L-asparagine:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)