#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P53999 uniprotkb:P03132 intact:EBI-998260|uniprotkb:Q96L29|ensembl:ENSP00000265073|ensembl:ENSP00000422078|ensembl:ENSP00000422806|ensembl:ENSP00000426850|ensembl:ENSP00000427100 intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650 psi-mi:tcp4_human(display_long)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:p14(gene name synonym)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PC4(gene name synonym)|uniprotkb:RPO2TC1(gene name synonym) psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short) psi-mi:"MI:0018"(two hybrid) Weger et al. (1999) imex:IM-22541|pubmed:9847329 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-9485234|imex:IM-22541-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512246.1|ensembl:ENSG00000113387(gene)|ensembl:ENST00000265073(transcript)|ensembl:ENST00000502897(transcript)|ensembl:ENST00000506237(transcript)|ensembl:ENST00000512913(transcript)|ensembl:ENST00000515355(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:P53999|rcsb pdb:1PCF|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|rcsb pdb:2C62|rcsb pdb:2PHE|rcsb pdb:4USG|go:"GO:0003697"(single-stranded DNA binding)|rcsb pdb:6YCS|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|refseq:NP_006704.3|refseq:XP_016864475.1|refseq:XP_016864476.1|dip:DIP-29044N mint:P03132|interpro:IPR014835(Rep protein catalytic like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1 - - function:Essential for DNA replication|comment:mint figure legend:3 and 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/24 2014/10/16 rogid:FqBKBuLmQS+idbd68EdKsTCzPg89606 rogid:12Ix12baqUBye/kP6FE/rjM69zY648242 intact-crc:F05B9905B3A07EF1|rigid:P1qvlmDPbtGdTdI+taqVNSMhGHw false necessary binding region:62-81 sufficient binding region:172-530|necessary binding region:172-224|mutation disrupting interaction:340-340 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53999 uniprotkb:Q89268 intact:EBI-998260|uniprotkb:Q96L29|ensembl:ENSP00000265073|ensembl:ENSP00000422078|ensembl:ENSP00000422806|ensembl:ENSP00000426850|ensembl:ENSP00000427100 intact:EBI-9485551|uniprotkb:O56651 psi-mi:tcp4_human(display_long)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:p14(gene name synonym)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PC4(gene name synonym)|uniprotkb:RPO2TC1(gene name synonym) psi-mi:rep78_aav2s(display_long)|uniprotkb:Rep78(gene name)|psi-mi:Rep78(display_short) psi-mi:"MI:0096"(pull down) Weger et al. (1999) imex:IM-22541|pubmed:9847329 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-9485460|imex:IM-22541-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512246.1|ensembl:ENSG00000113387(gene)|ensembl:ENST00000265073(transcript)|ensembl:ENST00000502897(transcript)|ensembl:ENST00000506237(transcript)|ensembl:ENST00000512913(transcript)|ensembl:ENST00000515355(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:P53999|rcsb pdb:1PCF|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|rcsb pdb:2C62|rcsb pdb:2PHE|rcsb pdb:4USG|go:"GO:0003697"(single-stranded DNA binding)|rcsb pdb:6YCS|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|refseq:NP_006704.3|refseq:XP_016864475.1|refseq:XP_016864476.1|dip:DIP-29044N interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|interpro:IPR014835(Rep protein catalytic like)|rcsb pdb:5BYG|refseq:YP_680423.1|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus) - - - figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/04/24 2014/10/16 rogid:FqBKBuLmQS+idbd68EdKsTCzPg89606 rogid:CRl4VPCCbv4a09MrPhwOddP9gG8648242 intact-crc:4FEB64699B8CE834|rigid:C72AulJQGBIHZKP03JRbvm25SMI false necessary binding region:62-81|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P53999 uniprotkb:P03132 intact:EBI-998260|uniprotkb:Q96L29|ensembl:ENSP00000265073|ensembl:ENSP00000422078|ensembl:ENSP00000422806|ensembl:ENSP00000426850|ensembl:ENSP00000427100 intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650 psi-mi:tcp4_human(display_long)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:p14(gene name synonym)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PC4(gene name synonym)|uniprotkb:RPO2TC1(gene name synonym) psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short) psi-mi:"MI:0018"(two hybrid) Weger et al. (1999) imex:IM-22541|pubmed:9847329 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-9485153|imex:IM-22541-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512246.1|ensembl:ENSG00000113387(gene)|ensembl:ENST00000265073(transcript)|ensembl:ENST00000502897(transcript)|ensembl:ENST00000506237(transcript)|ensembl:ENST00000512913(transcript)|ensembl:ENST00000515355(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:P53999|rcsb pdb:1PCF|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|rcsb pdb:2C62|rcsb pdb:2PHE|rcsb pdb:4USG|go:"GO:0003697"(single-stranded DNA binding)|rcsb pdb:6YCS|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|refseq:NP_006704.3|refseq:XP_016864475.1|refseq:XP_016864476.1|dip:DIP-29044N mint:P03132|interpro:IPR014835(Rep protein catalytic like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1 - - function:Essential for DNA replication|comment:mint figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/24 2014/10/16 rogid:FqBKBuLmQS+idbd68EdKsTCzPg89606 rogid:12Ix12baqUBye/kP6FE/rjM69zY648242 intact-crc:3EB23866C4D677A6|rigid:P1qvlmDPbtGdTdI+taqVNSMhGHw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P53999 uniprotkb:Q89269 intact:EBI-998260|uniprotkb:Q96L29|ensembl:ENSP00000265073|ensembl:ENSP00000422078|ensembl:ENSP00000422806|ensembl:ENSP00000426850|ensembl:ENSP00000427100 intact:EBI-9487072|uniprotkb:Q77XY0 psi-mi:tcp4_human(display_long)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:p14(gene name synonym)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PC4(gene name synonym)|uniprotkb:RPO2TC1(gene name synonym) psi-mi:rep40_aav2s(display_long)|uniprotkb:Rep40(gene name)|psi-mi:Rep40(display_short) psi-mi:"MI:0096"(pull down) Weger et al. (1999) imex:IM-22541|pubmed:9847329 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-9487038|imex:IM-22541-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512246.1|ensembl:ENSG00000113387(gene)|ensembl:ENST00000265073(transcript)|ensembl:ENST00000502897(transcript)|ensembl:ENST00000506237(transcript)|ensembl:ENST00000512913(transcript)|ensembl:ENST00000515355(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:P53999|rcsb pdb:1PCF|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|rcsb pdb:2C62|rcsb pdb:2PHE|rcsb pdb:4USG|go:"GO:0003697"(single-stranded DNA binding)|rcsb pdb:6YCS|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|refseq:NP_006704.3|refseq:XP_016864475.1|refseq:XP_016864476.1|dip:DIP-29044N interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|refseq:YP_680424.1|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0019079"(viral genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity) - - - figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/04/24 2014/10/16 rogid:FqBKBuLmQS+idbd68EdKsTCzPg89606 rogid:MM3Po5ObaveUnemPMtq2X4WB5TM648242 intact-crc:790D32E75A0BA6C2|rigid:Ksl4QVIsc8FNmUyaz45Fc3BjbK8 false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P53999 uniprotkb:P03132 intact:EBI-998260|uniprotkb:Q96L29|ensembl:ENSP00000265073|ensembl:ENSP00000422078|ensembl:ENSP00000422806|ensembl:ENSP00000426850|ensembl:ENSP00000427100 intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650 psi-mi:tcp4_human(display_long)|uniprotkb:SUB1 homolog(gene name synonym)|uniprotkb:Positive cofactor 4(gene name synonym)|uniprotkb:p14(gene name synonym)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PC4(gene name synonym)|uniprotkb:RPO2TC1(gene name synonym) psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short) psi-mi:"MI:0096"(pull down) Weger et al. (1999) imex:IM-22541|pubmed:9847329 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-9486356|imex:IM-22541-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512246.1|ensembl:ENSG00000113387(gene)|ensembl:ENST00000265073(transcript)|ensembl:ENST00000502897(transcript)|ensembl:ENST00000506237(transcript)|ensembl:ENST00000512913(transcript)|ensembl:ENST00000515355(transcript)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003173(Transcriptional coactivator p15)|interpro:IPR009044(ssDNA-binding transcriptional regulator)|mint:P53999|rcsb pdb:1PCF|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|rcsb pdb:2C62|rcsb pdb:2PHE|rcsb pdb:4USG|go:"GO:0003697"(single-stranded DNA binding)|rcsb pdb:6YCS|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0051053"(negative regulation of DNA metabolic process)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060395"(SMAD protein signal transduction)|refseq:NP_006704.3|refseq:XP_016864475.1|refseq:XP_016864476.1|dip:DIP-29044N mint:P03132|interpro:IPR014835(Rep protein catalytic like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1 - - function:Essential for DNA replication|comment:mint figure legend:6B and C|comment:"SUB1/PC4 phosphorylated (by addition of CKII) and nonphosphorylated form showed interaction. Rep68 mutation lys340his did not change the interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/04/24 2014/10/16 rogid:FqBKBuLmQS+idbd68EdKsTCzPg89606 rogid:12Ix12baqUBye/kP6FE/rjM69zY648242 intact-crc:7DE9660389FFAE75|rigid:P1qvlmDPbtGdTdI+taqVNSMhGHw false sufficient binding region:62-127 glutathione s tranferase tag:?-?|sufficient binding region:172-530 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)