#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27958-PRO_0000037570	uniprotkb:P60033	intact:EBI-6904269	intact:EBI-712921|ensembl:ENSP00000263645|uniprotkb:P18582|uniprotkb:Q5U0J6	psi-mi:p27958-pro_0000037570(display_long)	psi-mi:cd81_human(display_long)|uniprotkb:26 kDa cell surface protein TAPA-1(gene name synonym)|uniprotkb:Target of the antiproliferative antibody 1(gene name synonym)|uniprotkb:Tetraspanin-28(gene name synonym)|uniprotkb:CD81(gene name)|psi-mi:CD81(display_short)|uniprotkb:TAPA1(gene name synonym)|uniprotkb:TSPAN28(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Pileri et al. (1998)	pubmed:9794763|imex:IM-25851	taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-9119606|imex:IM-25851-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-706378(chain-parent)	ensembl:ENSG00000110651(gene)|ensembl:ENST00000263645(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014905"(myoblast fusion involved in skeletal muscle regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031623"(receptor internalization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035783"(CD4-positive, alpha-beta T cell costimulation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0043128"(positive regulation of 1-phosphatidylinositol 4-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072675"(osteoclast fusion)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1904352"(positive regulation of protein catabolic process in the vacuole)|go:"GO:1905521"(regulation of macrophage migration)|go:"GO:1905676"(positive regulation of adaptive immune memory response)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000301(CD9/CD37/CD63 antigen)|interpro:IPR008952(Tetraspanin)|interpro:IPR018499|interpro:IPR018503|mint:P60033|rcsb pdb:1G8Q|rcsb pdb:1IV5|rcsb pdb:2AVZ|rcsb pdb:3X0E|rcsb pdb:5DFV|rcsb pdb:5DFW|rcsb pdb:5M2C|rcsb pdb:5M33|rcsb pdb:5M3D|rcsb pdb:5M3T|rcsb pdb:5M4R|rcsb pdb:5TCX|rcsb pdb:6EJG|rcsb pdb:6EJM|rcsb pdb:6EK2|rcsb pdb:6U9S|rcsb pdb:7JIC|reactome:R-HSA-198933|reactome:R-HSA-977606|refseq:NP_004347.1|refseq:NP_001284578.1	-	chain-seq-start:384|chain-seq-end:746	-	figure legend:Fig. 2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/02/06	2017/09/02	rogid:XFfKziasvR5/eMo+Xm/kI2cwpPc63746	rogid:LPDYYmkI2TtoCarkcBXuaibfB6A9606	intact-crc:D63E9E32367A0752|rigid:0zdbw7zJaiQx/AYD0Q4yEhc0Ylk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)