#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97924	uniprotkb:P54256	intact:EBI-1397166|uniprotkb:O70135|uniprotkb:Q6IV51|uniprotkb:Q9JIF1|uniprotkb:Q9JIF2|uniprotkb:Q9JIG0|uniprotkb:Q9JIH3	intact:EBI-994539	psi-mi:kalrn_rat(display_long)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Colomer et al. (1997)	pubmed:9285789|imex:IM-22987	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639603|imex:IM-22987-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621865|refseq:NP_114451.2|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rcsb pdb:1U3O|rcsb pdb:2KR9|interpro:IPR003599(Immunoglobulin subtype)|reactome:R-RNO-193648|reactome:R-RNO-3928662|reactome:R-RNO-416476|reactome:R-RNO-5687128|interpro:IPR028570|rcsb pdb:5O33|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|interpro:IPR036865|reactome:R-RNO-416482|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|reactome:R-RNO-8980692|reactome:R-RNO-9013149|reactome:R-RNO-9013408	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	-	-	figure legend:no figure|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/10	2014/10/16	rogid:IQVDCaidjkQ2Ddbz4PpMpLiDIu010116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:AB871EE6088B8DBE|rigid:rBkjXaEqZIzepPxXHvNDO0ucU/g	false	-	sufficient binding region:1-313	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97924	uniprotkb:P54256	intact:EBI-1397166|uniprotkb:O70135|uniprotkb:Q6IV51|uniprotkb:Q9JIF1|uniprotkb:Q9JIF2|uniprotkb:Q9JIG0|uniprotkb:Q9JIH3	intact:EBI-994539	psi-mi:kalrn_rat(display_long)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Colomer et al. (1997)	pubmed:9285789|imex:IM-22987	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639622|imex:IM-22987-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621865|refseq:NP_114451.2|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rcsb pdb:1U3O|rcsb pdb:2KR9|interpro:IPR003599(Immunoglobulin subtype)|reactome:R-RNO-193648|reactome:R-RNO-3928662|reactome:R-RNO-416476|reactome:R-RNO-5687128|interpro:IPR028570|rcsb pdb:5O33|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|interpro:IPR036865|reactome:R-RNO-416482|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|reactome:R-RNO-8980692|reactome:R-RNO-9013149|reactome:R-RNO-9013408	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	-	-	figure legend:1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/10	2014/10/16	rogid:IQVDCaidjkQ2Ddbz4PpMpLiDIu010116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:F6D9B8A070F0E778|rigid:rBkjXaEqZIzepPxXHvNDO0ucU/g	false	-	sufficient binding region:1-313	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54256	uniprotkb:P42858	intact:EBI-994539	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Colomer et al. (1997)	pubmed:9285789|imex:IM-22987	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639631|imex:IM-22987-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:1|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/07/10	2014/10/16	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	intact-crc:EA3E861594A4471A|rigid:IzbNocv+fw2mJrf5pZxqwjJgA9w	false	sufficient binding region:293-442	mutation:18..18-38..38	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97924	uniprotkb:P54256	intact:EBI-1397166|uniprotkb:O70135|uniprotkb:Q6IV51|uniprotkb:Q9JIF1|uniprotkb:Q9JIF2|uniprotkb:Q9JIG0|uniprotkb:Q9JIH3	intact:EBI-994539	psi-mi:kalrn_rat(display_long)|uniprotkb:Huntingtin-associated protein-interacting protein(gene name synonym)|uniprotkb:Protein Duo(gene name synonym)|uniprotkb:Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 10(gene name synonym)|uniprotkb:Kalrn(gene name)|psi-mi:Kalrn(display_short)|uniprotkb:Duo(gene name synonym)|uniprotkb:Hapip(gene name synonym)	psi-mi:hap1_rat(display_long)|uniprotkb:Hap1(gene name)|psi-mi:Hap1(display_short)	psi-mi:"MI:0096"(pull down)	Colomer et al. (1997)	pubmed:9285789|imex:IM-22987	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9639653|imex:IM-22987-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621865|refseq:NP_114451.2|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|rcsb pdb:1U3O|rcsb pdb:2KR9|interpro:IPR003599(Immunoglobulin subtype)|reactome:R-RNO-193648|reactome:R-RNO-3928662|reactome:R-RNO-416476|reactome:R-RNO-5687128|interpro:IPR028570|rcsb pdb:5O33|interpro:IPR035899|interpro:IPR036028|interpro:IPR036116|interpro:IPR036179|interpro:IPR036865|reactome:R-RNO-416482|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0035176"(social behavior)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042711"(maternal behavior)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0046959"(habituation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|reactome:R-RNO-8980692|reactome:R-RNO-9013149|reactome:R-RNO-9013408	go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021979"(hypothalamus cell differentiation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030030"(cell projection organization)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032901"(positive regulation of neurotrophin production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048311"(mitochondrion distribution)|go:"GO:0048403"(brain-derived neurotrophic factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098957"(anterograde axonal transport of mitochondrion)|go:"GO:0016234"(inclusion body)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008104"(protein localization)|go:"GO:0010976"(positive regulation of neuron projection development)|rgd:68327|refseq:NP_077047.1|refseq:NP_817091.1|interpro:IPR006933(HAP1, N-terminal)|mint:P54256	-	-	-	figure legend:2|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/10	2014/10/16	rogid:IQVDCaidjkQ2Ddbz4PpMpLiDIu010116	rogid:CHICvXtJfygpsqLcMZhgWS7+iqc10116	intact-crc:09D415EEAF957C40|rigid:rBkjXaEqZIzepPxXHvNDO0ucU/g	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)