#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O75807 uniprotkb:P62137 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357187|ensembl:ENSMUSP00000039109|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:Q3U7G7|uniprotkb:Q9Z1G2 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1a_mouse(display_long)|uniprotkb:Ppp1ca(gene name)|psi-mi:Ppp1ca(display_short)|uniprotkb:Ppp1a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979206|imex:IM-23248-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62137|rcsb pdb:5ZQV|rcsb pdb:5ZT0|reactome:R-MMU-180024|ensembl:ENSMUSG00000040385(gene)|ensembl:ENSMUST00000046094(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|refseq:NP_114074.1 - - - figure legend:Fig. 3D|comment:"Presence of Tardbp in the complex was induced by arsenite in both wild-type and the eIFalpha knockin mutation (Ser51Ala) in the mouse eIF2A gene, that prevents its phosphorylation, establishing that eIF2alpha phosphorylation was not required for the formation of this complex"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2014/10/28 2014/11/18 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:kr38FkfqhN5ex5rxh4ZJbSdd8IM10090 intact-crc:A04228F0997CD64D|rigid:1hFNdpL8JE5iI3jxl6T1g2C/ymM false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q921F2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-6876933|ensembl:ENSMUSP00000081142|uniprotkb:Q3U591|uniprotkb:Q3V0E7 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_mouse(display_long)|uniprotkb:Tardbp(gene name)|psi-mi:Tardbp(display_short)|uniprotkb:Tdp43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979206|imex:IM-23248-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001003899.1|refseq:NP_001008545.1|refseq:NP_001008546.1|refseq:NP_001292354.1|ensembl:ENSMUSG00000041459(gene)|ensembl:ENSMUST00000084125(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q921F2|rcsb pdb:3D2W|refseq:NP_663531.1 - - - figure legend:Fig. 3D|comment:"Presence of Tardbp in the complex was induced by arsenite in both wild-type and the eIFalpha knockin mutation (Ser51Ala) in the mouse eIF2A gene, that prevents its phosphorylation, establishing that eIF2alpha phosphorylation was not required for the formation of this complex"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2014/10/28 2014/11/18 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:j1U3NZd8O/lAclOPSRt10NY58e810090 intact-crc:A04228F0997CD64D|rigid:1hFNdpL8JE5iI3jxl6T1g2C/ymM false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:O15078 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1811944|uniprotkb:Q1PSK5|uniprotkb:Q66GS8|uniprotkb:Q9H2G6|uniprotkb:Q9H6Q7|uniprotkb:Q9H8I0|ensembl:ENSP00000448012 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ce290_human(display_long)|uniprotkb:CEP290(gene name)|psi-mi:CEP290(display_short)|uniprotkb:KIAA0373(gene name synonym)|uniprotkb:NPHP6(gene name synonym)|uniprotkb:Nephrocystin-6(gene name synonym)|uniprotkb:Tumor antigen se2-2(gene name synonym)|uniprotkb:Cancer/testis antigen 87(gene name synonym)|uniprotkb:BBS14(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 14 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_079390.3|dip:DIP-46541N|ensembl:ENSG00000198707(gene)|ensembl:ENST00000552810(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030902"(hindbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036038"(MKS complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048793"(pronephros development)|go:"GO:0060271"(cilium assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|go:"GO:1905349"(ciliary transition zone assembly)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR026201|interpro:IPR032321|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:89HbDVs4UVmzftFFLO/pHklTiUQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O14545 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1396921|uniprotkb:B4DI89|uniprotkb:A8K5L6|intact:EBI-28969419|ensembl:ENSP00000257604|ensembl:ENSP00000396526 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:trad1_human(display_long)|uniprotkb:TRAFD1(gene name)|psi-mi:TRAFD1(display_short)|uniprotkb:FLN29(gene name synonym)|uniprotkb:Protein FLN29(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSP00000257604|ensembl:ENSP00000396526|ensembl:ENST00000552890|ensembl:ENSP00000447340|refseq:NP_001137378.1|refseq:NP_006691.1|ensembl:ENSG00000135148(gene)|ensembl:ENST00000257604(transcript)|ensembl:ENST00000412615(transcript)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2D9K - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hDY19qxNvWdsjDOoUEpuYfe0cdA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B7Z4V2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-8011650|intact:MINT-8395013 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b7z4v2_human(display_long)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Stress-70 protein, mitochondrial(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR012725(Chaperone DnaK)|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR043129 - - comment:mint|comment:homomint dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Pm4HQ6qAXFJM55Z35qQU2xal25k9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9NYZ3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2511327|intact:EBI-28974182|ensembl:ENSP00000415430|uniprotkb:Q9BRE0|uniprotkb:Q53GX5|uniprotkb:Q20WK2|uniprotkb:Q9UGZ9|uniprotkb:Q6DHX4|uniprotkb:Q5R3I6|uniprotkb:Q9Y557|uniprotkb:B0QYM3 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:gtse1_human(display_long)|uniprotkb:GTSE1(gene name)|psi-mi:GTSE1(display_short)|uniprotkb:Protein B99 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000075218(gene)|ensembl:ENST00000454366(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007017"(microtubule-based process)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|interpro:IPR026657|interpro:IPR026659|interpro:IPR032768|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-69481|reactome:R-HSA-8852276|ensembl:ENSP00000415430|refseq:NP_057510.4 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3vSRRbx11yGNbuaniX7ZtqE/cLI9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P62136 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P54652 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P40939 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q13263 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P13639 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-352560|uniprotkb:Q58J86|uniprotkb:B2RMP5|uniprotkb:D6W618|ensembl:ENSP00000307940 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ef2_human(display_long)|uniprotkb:EEF2(gene name)|psi-mi:EEF2(display_short)|uniprotkb:EF2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001952.1|ensembl:ENSG00000167658(gene)|ensembl:ENST00000309311(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006414"(translational elongation)|go:"GO:0007568"(aging)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051593"(response to folic acid)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031157|interpro:IPR035647|interpro:IPR041095|mint:P13639|rcsb pdb:4V6X|rcsb pdb:6D9J|rcsb pdb:6Z6M|rcsb pdb:6Z6N|reactome:R-HSA-156902|reactome:R-HSA-5336415|reactome:R-HSA-5358493|reactome:R-HSA-6798695|reactome:R-HSA-8876725 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:US1dzGQ5V1oBXVtYeGt5H3HCIr09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q3ZCM7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-302558|ensembl:ENSP00000456206|intact:EBI-1390656|uniprotkb:Q5SQX9|uniprotkb:Q8WZ78 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tbb8_human(display_long)|uniprotkb:TUBB8(gene name)|psi-mi:TUBB8(display_short)|uniprotkb:Tubulin beta 8 class VIII(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-9619483|ensembl:ENSG00000261456(gene)|ensembl:ENST00000568584(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007056"(spindle assembly involved in female meiosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072687"(meiotic spindle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q3ZCM7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|refseq:NP_817124.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:bTJnhl0qEm2ACoHQ7IOcn5Rx7xM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q562R1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1773495|uniprotkb:Q562R2|uniprotkb:Q562S9|uniprotkb:Q562X8|uniprotkb:B2RPJ1|ensembl:ENSP00000416706 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:actbl_human(display_long)|uniprotkb:ACTBL2(gene name)|psi-mi:ACTBL2(display_short)|uniprotkb:Kappa-actin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001017992.1|ensembl:ENSG00000169067(gene)|ensembl:ENST00000423391(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0007409"(axonogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0045202"(synapse)|go:"GO:0048870"(cell motility)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:Q562R1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:GTzKP5YRJGH8ocAJW0WEsdQFEdc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P53618 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P11021 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P35527 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356382|uniprotkb:O00109|uniprotkb:Q0IJ47|uniprotkb:Q14665|ensembl:ENSP00000246662 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:k1c9_human(display_long)|uniprotkb:KRT9(gene name)|psi-mi:KRT9(display_short)|uniprotkb:Keratin-9(gene name synonym)|uniprotkb:Cytokeratin-9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000217.2|ensembl:ENSG00000171403(gene)|ensembl:ENST00000246662(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0043588"(skin development)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P35527|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:m4EXfxbK2t1/EmI04YODKTJ02Zw9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00178 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-4403245|uniprotkb:Q6IC67|intact:EBI-28983557|ensembl:ENSP00000216044 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:gtpb1_human(display_long)|uniprotkb:GTPBP1(gene name)|psi-mi:GTPBP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004277.2|ensembl:ENSP00000216044|ensembl:ENSG00000100226(gene)|ensembl:ENST00000216044(transcript)|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR035531|interpro:IPR039263 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:xgrFwHgoeIjQuqyzXCt0+Y2IQNk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P54886 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P62140 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DQE5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977229 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dqe5_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR019523 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:zDPp4S63+h+3bytCQteC58m8nGQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P13645 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:z100yyq3b63P0ARy2lE2ELyJeik9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q1MSW8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9371555 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q4KMX3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977217 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q4kmx3_human(display_long)|uniprotkb:JPH1(gene name)|psi-mi:JPH1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR017191(Junctophilin)|interpro:IPR003409(MORN motif)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030314"(junctional membrane complex) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hNzoBaSCtT545h20bEoZKQShMEM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P54105 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-724693|uniprotkb:Q0VDK6|uniprotkb:Q9NRD2|uniprotkb:Q9NRD3|uniprotkb:B2RCS9|ensembl:ENSP00000433919|ensembl:ENSP00000434311 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:icln_human(display_long)|uniprotkb:Chloride conductance regulatory protein ICln(gene name synonym)|uniprotkb:Chloride channel, nucleotide sensitive 1A(gene name synonym)|uniprotkb:Chloride ion current inducer protein(gene name synonym)|uniprotkb:Reticulocyte pICln(gene name synonym)|uniprotkb:CLNS1A(gene name)|psi-mi:CLNS1A(display_short)|uniprotkb:ICLN(gene name synonym)|uniprotkb:CLCI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001284.1|refseq:NP_001298128.1|refseq:NP_001298129.1|refseq:NP_001298130.1|refseq:NP_001298131.1|ensembl:ENSG00000074201(gene)|ensembl:ENST00000525428(transcript)|ensembl:ENST00000528364(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|interpro:IPR003521(Nucleotide-sensitive chloride conductance regulator)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039924|mint:P54105|rcsb pdb:6V0O|reactome:R-HSA-191859|dip:DIP-44185N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:dGx9UwPj9VBp1CiPTRCXnT3IYt89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P52732 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-355697|uniprotkb:A0AV49|uniprotkb:Q15716|uniprotkb:Q5VWX0|uniprotkb:B2RMV3|ensembl:ENSP00000260731 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:kif11_human(display_long)|uniprotkb:KIF11(gene name)|psi-mi:KIF11(display_short)|uniprotkb:EG5(gene name synonym)|uniprotkb:KNSL1(gene name synonym)|uniprotkb:TRIP5(gene name synonym)|uniprotkb:Kinesin-related motor protein Eg5(gene name synonym)|uniprotkb:Kinesin-like spindle protein HKSP(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 5(gene name synonym)|uniprotkb:Kinesin-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004514.2|ensembl:ENSG00000138160(gene)|ensembl:ENST00000260731(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|rcsb pdb:1X88|rcsb pdb:1YRS|rcsb pdb:2FKY|rcsb pdb:2FL2|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR025901|interpro:IPR027417|interpro:IPR036961|rcsb pdb:1II6|rcsb pdb:1Q0B|rcsb pdb:2FL6|rcsb pdb:2FME|rcsb pdb:2G1Q|rcsb pdb:2GM1|rcsb pdb:2IEH|rcsb pdb:2PG2|rcsb pdb:2Q2Y|rcsb pdb:2Q2Z|rcsb pdb:2UYI|rcsb pdb:2UYM|rcsb pdb:2WOG|rcsb pdb:2X2R|rcsb pdb:2X7C|rcsb pdb:2X7D|rcsb pdb:2X7E|rcsb pdb:2XAE|rcsb pdb:3CJO|rcsb pdb:3HQD|rcsb pdb:3K3B|rcsb pdb:3K5E|rcsb pdb:3KEN|rcsb pdb:3L9H|rcsb pdb:3WPN|rcsb pdb:3ZCW|rcsb pdb:4A1Z|rcsb pdb:4A28|rcsb pdb:4A50|rcsb pdb:4A51|rcsb pdb:4A5Y|rcsb pdb:4AP0|rcsb pdb:4AQV|rcsb pdb:4AQW|rcsb pdb:4AS7|rcsb pdb:4B7B|rcsb pdb:4BBG|rcsb pdb:4BXN|rcsb pdb:4CK5|rcsb pdb:4CK6|rcsb pdb:4CK7|rcsb pdb:4ZCA|rcsb pdb:4ZHI|rcsb pdb:5JV3|rcsb pdb:5ZO7|rcsb pdb:5ZO8|rcsb pdb:5ZO9|rcsb pdb:6G6Y|rcsb pdb:6G6Z|rcsb pdb:6HKX|rcsb pdb:6HKY|rcsb pdb:6TA3|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6TLE|rcsb pdb:6TRL|rcsb pdb:6Y1I|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-53686N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:YimbfuWYTSuyqgfs2RF8kCx2+xE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O95831 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356440|uniprotkb:Q5JUZ7|uniprotkb:Q6I9X6|uniprotkb:Q9Y3I3|uniprotkb:Q9Y3I4|uniprotkb:A4QPB4|uniprotkb:B1ALN1|uniprotkb:B2RB08|intact:EBI-2561858|uniprotkb:D3DTE9|uniprotkb:Q1L6K6|uniprotkb:Q2QKE4|uniprotkb:Q1L6K4|ensembl:ENSP00000287295|uniprotkb:E9PRR0 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:aifm1_human(display_long)|uniprotkb:AIFM1(gene name)|psi-mi:AIFM1(display_short)|uniprotkb:AIF(gene name synonym)|uniprotkb:PDCD8(gene name synonym)|uniprotkb:Programmed cell death protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001124319.1|refseq:NP_004199.1|refseq:NP_665811.1|refseq:NP_001124318.2|rcsb pdb:5FS6|rcsb pdb:5FS7|rcsb pdb:5FS8|rcsb pdb:5FS9|rcsb pdb:5KVH|rcsb pdb:5KVI|ensembl:ENSG00000156709(gene)|ensembl:ENST00000287295(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016174"("NAD(P)H oxidase H2O2-forming activity")|go:"GO:0016651"("oxidoreductase activity, acting on NAD(P)H")|go:"GO:0030182"(neuron differentiation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071949"(FAD binding)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902510"(regulation of apoptotic DNA fragmentation)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR029324|interpro:IPR036188|mint:O95831|rcsb pdb:1M6I|rcsb pdb:4BUR|rcsb pdb:4BV6|rcsb pdb:4FDC|rcsb pdb:4LII|rcsb pdb:5FMH|dip:DIP-32975N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:tAY+mPStfDGbCN4OpvHF4ljQ69I9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P35908 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1247312|uniprotkb:Q4VAQ2|ensembl:ENSP00000310861 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:k22e_human(display_long)|uniprotkb:KRT2(gene name)|psi-mi:KRT2(display_short)|uniprotkb:KRT2A(gene name synonym)|uniprotkb:KRT2E(gene name synonym)|uniprotkb:Cytokeratin-2e(gene name synonym)|uniprotkb:Keratin-2e(gene name synonym)|uniprotkb:Type-II keratin Kb2(gene name synonym)|uniprotkb:Keratin-2 epidermis(gene name synonym)|uniprotkb:Epithelial keratin-2e(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000414.2|ensembl:ENSG00000172867(gene)|ensembl:ENST00000309680(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0031424"(keratinization)|go:"GO:0032980"(keratinocyte activation)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P35908|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0051546"(keratinocyte migration) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:T7LeB8nkZzNjUb8DWdkxbrl5f789606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P11142 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KRS1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977733 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3krs1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR042241|interpro:IPR041470|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005874"(microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0043015"(gamma-tubulin binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:NdJGvPKR8KCrpkSnR/2up4K2it49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KX11 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977889 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3kx11_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001008800.1|refseq:NP_005989.3|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413|interpro:IPR027410|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:mpgQqashsNjYXuk3w7Hjc9OGBbg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q12931 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1055869|uniprotkb:O43642|uniprotkb:O75235|uniprotkb:Q9UHL5|uniprotkb:B4DR68|uniprotkb:F5H897|uniprotkb:D3DUC8|ensembl:ENSP00000246957 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:trap1_human(display_long)|uniprotkb:TRAP1(gene name)|psi-mi:TRAP1(display_short)|uniprotkb:HSP75(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein(gene name synonym)|uniprotkb:TNFR-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_057376.2|refseq:NP_001258978.1|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0009386"(translational attenuation)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901856"(negative regulation of cellular respiration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:Q12931|rcsb pdb:4Z1F|rcsb pdb:4Z1G|rcsb pdb:4Z1H|rcsb pdb:4Z1I|rcsb pdb:5F3K|rcsb pdb:5F5R|rcsb pdb:5HPH|rcsb pdb:5Y3N|rcsb pdb:5Y3O|rcsb pdb:6XG6|rcsb pdb:7C04|rcsb pdb:7C05|rcsb pdb:7C7B|rcsb pdb:7C7C|reactome:R-HSA-611105|ensembl:ENSG00000126602(gene)|ensembl:ENST00000246957(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|dip:DIP-6250N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:O/i+7vgZQcDQF3xJTeqNLbWiQ8U9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KSH1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2510457 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ksh1_human(display_long)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:hCG_1784554(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3xYNX/dcd5LtW8Ne+TP0TYHEUqY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9ULX6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P51398 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-355912|uniprotkb:Q13044|uniprotkb:Q96Q20|uniprotkb:Q68CT7|uniprotkb:B4DP59|uniprotkb:E7EM60|uniprotkb:B4DY62|ensembl:ENSP00000341692|ensembl:ENSP00000357320 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:rt29_human(display_long)|uniprotkb:DAP3(gene name)|psi-mi:DAP3(display_short)|uniprotkb:MRPS29(gene name synonym)|uniprotkb:Death-associated protein 3(gene name synonym)|uniprotkb:Ionizing radiation resistance conferring protein(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS29(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001186778.1|refseq:NP_004623.1|refseq:NP_387506.1|refseq:NP_001186779.1|refseq:NP_001186780.1|refseq:XP_005245537.1|refseq:XP_005245538.1|ensembl:ENSG00000132676(gene)|ensembl:ENST00000343043(transcript)|ensembl:ENST00000368336(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR008092(Death associated protein 3)|interpro:IPR019368|interpro:IPR027417|mint:P51398|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_016857780.1|refseq:XP_016857781.1|refseq:XP_016857782.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:xSIyqKH4F49Iu+AVuVThJWsi9EA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B7Z720 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977904 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b7z720_human(display_long)|uniprotkb:ELF2(gene name)|psi-mi:ELF2(display_short)|uniprotkb:hCG_1641148(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR000418(Ets)|interpro:IPR022084|refseq:NP_001263387.1|interpro:IPR036388|interpro:IPR036390|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043565"(sequence-specific DNA binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:aJByVQlAPZSVmDeitMqgktCHoFQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DMY3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977868 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dmy3_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR012956(CBF, N-terminal)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034846|interpro:IPR035979|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:EYOUmwvDpSLGOCjxp8KgchjokSc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P50990 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P63151 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:evS6klM2alZXtMthVsshKkrNgiA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B5BUB1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9512878 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b5bub1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR037938|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR027238|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR041048|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0097255"(R2TP complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:aBcJKlV75E/3Ht94Dp+scTxvelc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DV95 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977916 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dv95_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:NP_001284484.1|refseq:NP_001284485.1|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3jdlfo8CvVFalmR7C0gMAGW1t+o9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KSQ7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977940 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ksq7_human(display_long)|uniprotkb:DBN1(gene name)|psi-mi:DBN1(display_short)|uniprotkb:hCG_2039393(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR028438|go:"GO:0003779"(actin binding)|go:"GO:0007015"(actin filament organization) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/ZQQL8W7E8Q5rki/j/QyL0C1VXc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DKS0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-4404716 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dks0_human(display_long)|uniprotkb:Solute carrier family 16 member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011701(Major facilitator superfamily MFS-1)|refseq:NP_001159968.1|interpro:IPR030757|interpro:IPR036259|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015129"(lactate transmembrane transporter activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:WkP0BTG1bkd+4tLHVJiucMHa/As9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KY60 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977879 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ky60_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR021786|interpro:IPR009057(Homeodomain-like)|interpro:IPR017930|interpro:IPR001005(SANT, DNA-binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0051301"(cell division) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:+BvtBXnjgx82UcH5mKq6dHjU29Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DNN2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977843 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dnn2_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:hCG_22857(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|refseq:NP_001304030.1|refseq:NP_001304031.1|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hzJ3g8nLyXfRaks9af5BsuHeNRI9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DIS6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977853 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dis6_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001186628.1|refseq:NP_064547.2|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR007502(Helicase-associated region)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:zfHI/qSLmdywDLNTlRqtqEo/p8k9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DMA8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977790 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dma8_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR019821|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR036961|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:1990939" - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:0Uh5+RYDhK33mmPWYXBUnJ6pEWU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UJZ1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00571 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-353779|uniprotkb:O15536|uniprotkb:A8K538|uniprotkb:B4E3E8|ensembl:ENSP00000478443|ensembl:ENSP00000486516|ensembl:ENSP00000486720|ensembl:ENSP00000487224|ensembl:ENSP00000494040 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ddx3x_human(display_long)|uniprotkb:DDX3X(gene name)|psi-mi:DDX3X(display_short)|uniprotkb:DBX(gene name synonym)|uniprotkb:DDX3(gene name synonym)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:Helicase-like protein 2(gene name synonym)|uniprotkb:DEAD box, X isoform(gene name synonym)|uniprotkb:CAP-Rf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001347.3|refseq:NP_001180345.1|refseq:NP_001180346.1|ensembl:ENSG00000215301(gene)|ensembl:ENST00000478993(transcript)|ensembl:ENST00000629496(transcript)|ensembl:ENST00000629785(transcript)|ensembl:ENST00000630255(transcript)|ensembl:ENST00000644876(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00571|rcsb pdb:2I4I|rcsb pdb:2JGN|rcsb pdb:3JRV|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PX9|rcsb pdb:4PXA|rcsb pdb:5E7I|rcsb pdb:5E7J|rcsb pdb:5E7M|rcsb pdb:6CZ5|rcsb pdb:6O5F|reactome:R-HSA-6798695|dip:DIP-27551N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:XCZgGbfPyxLnvabmWRNNgG3HHIs9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DWV9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977740 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dwv9_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:kfqOmfIA3NpGNckt4QpU2I5pG849606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O14757 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KSX3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977802 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ksx3_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034504|interpro:IPR035979|go:"GO:0003723"(RNA binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Z9+O5M8lGSaDiSjcdZ5gZbcrIRw9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KS98 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977771|ensembl:ENSP00000276682 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ks98_human(display_long)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3 gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:hCG_20900(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000147677(gene)|ensembl:ENST00000276682(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:ku9n+wIb9o9AHPxq9cLUihheT+49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DLG2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977730 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dlg2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR041686 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:TC4iqwcafCwzHxwwsK/RnHwgQLA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P08107 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q96TA2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2818916|uniprotkb:Q9UMR9|uniprotkb:Q9H1Q0|uniprotkb:Q5T8D9|uniprotkb:D3DRV8|uniprotkb:D3DRV9|uniprotkb:B4DNM1|intact:EBI-10989776|ensembl:ENSP00000318480 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ymel1_human(display_long)|uniprotkb:YME1L1(gene name)|psi-mi:YME1L1(display_short)|uniprotkb:FTSH1(gene name synonym)|uniprotkb:YME1L(gene name synonym)|uniprotkb:ATP-dependent metalloprotease FtsH1(gene name synonym)|uniprotkb:Meg-4(gene name synonym)|uniprotkb:Presenilin-associated metalloprotease(gene name synonym)|uniprotkb:YME1-like protein 1(gene name synonym)|uniprotkb:UNQ1868/PRO4304(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_647473.1|refseq:NP_055078.1|refseq:NP_001240795.1|ensembl:ENSG00000136758(gene)|ensembl:ENST00000326799(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0034214"(protein hexamerization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q96TA2|reactome:R-HSA-8949664 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:73ThpwDPUEO7f5SBfSljmbwJLn09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DY09 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977811|ensembl:ENSP00000482909 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dy09_human(display_long)|uniprotkb:ILF2(gene name)|psi-mi:ILF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001254738.1|ensembl:ENSG00000143621(gene)|ensembl:ENST00000615950(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR006561(DZF)|interpro:IPR043519 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:kaIIJiVuPkQpxlnUiVaYRqveCvM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DDF7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977759 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4ddf7_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000357(HEAT)|interpro:IPR021133|interpro:IPR031090|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0065003"(protein-containing complex assembly) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:ygjoHuYmXHoK0QoLKxuSWxX9XUQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KU03 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977752 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3ku03_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR008604(E-MAP-115)|refseq:NP_001273295.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0015630"(microtubule cytoskeleton) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:UbzdtZtW23YigPVeA7uqBp8Z7hc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KRV2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977833 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3krv2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:NP_001276841.1|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:faIF7enrTNofYMfPl+n/PWgAhsw9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DL07 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977927 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dl07_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR027417|interpro:IPR036640|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:m8b57GtJtGaLqBnF6i3FV04C/uQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B4DMZ9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977825 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b4dmz9_human(display_long)|uniprotkb:Processed cyclic AMP-responsive element-binding protein 3-like protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR029807|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:TvODgeaC9Flr+CNsJHQkbEPV1Rc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q96RF0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A2NJV5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977265 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:kv229_human(display_long)|uniprotkb:IGKV2-29(gene name)|psi-mi:IGKV2-29(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013106(Immunoglobulin V-set)|reactome:R-HSA-5690714|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|reactome:R-HSA-202733|reactome:R-HSA-977606|interpro:IPR036179|reactome:R-HSA-9664323|reactome:R-HSA-9664422|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KZYc77tFTs1buXBX2hjdcuvsx7Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q92598 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A0JLN5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977315 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a0jln5_human(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR004728(Translocation protein Sec62)|go:"GO:0015031"(protein transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:VZDbnYvM0pZl3+dqF6STx8OenWs9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q96JG8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-721864|uniprotkb:Q8WXW4|uniprotkb:Q9BQ84|uniprotkb:Q9BYH3|uniprotkb:Q9BYH4|uniprotkb:A8K093|uniprotkb:Q5HYN6|uniprotkb:Q9BVH1|uniprotkb:Q9H217|ensembl:ENSP00000335385|ensembl:ENSP00000423848|ensembl:ENSP00000507908 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:magd4_human(display_long)|uniprotkb:MAGED4B(gene name)|psi-mi:MAGED4B(display_short)|uniprotkb:MAGED4A(gene name synonym)|uniprotkb:MAGE-D4 antigen(gene name synonym)|uniprotkb:MAGE-E1 antigen(gene name synonym)|uniprotkb:MAGED4(gene name)|psi-mi:MAGED4(display_short)|uniprotkb:KIAA1859(gene name synonym)|uniprotkb:MAGEE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001092270.1|refseq:NP_001229291.1|refseq:NP_110428.2|refseq:NP_803879.1|refseq:NP_803881.1|refseq:XP_011529124.1|refseq:NP_001258990.1|refseq:NP_001258991.1|refseq:NP_001258992.1|refseq:XP_006724670.1|refseq:XP_006724671.1|refseq:XP_016885365.1|ensembl:ENSG00000154545(gene)|ensembl:ENSG00000187243(gene)|ensembl:ENST00000335504(transcript)|ensembl:ENST00000471932(transcript)|interpro:IPR002190(MAGE protein)|interpro:IPR030091|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|ensembl:ENST00000497164(transcript) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:xmAofBgVdNieZVQMV9ag6Pq++DA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A2A2Q9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977257|ensembl:ENSP00000380455 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a2a2q9_human(display_long)|uniprotkb:Protein AAR2 homolog(gene name synonym)|uniprotkb:AAR2(gene name)|psi-mi:AAR2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000131043(gene)|ensembl:ENST00000397286(transcript)|interpro:IPR007946(AAR2)|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:uYSPGjNrDkRpjeOaEJN9SIC9YrM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UHK0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2563549|uniprotkb:Q8WVM5|uniprotkb:Q96SG1|ensembl:ENSP00000368459 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:nufp1_human(display_long)|uniprotkb:Nuclear FMRP-interacting protein 1(gene name synonym)|uniprotkb:NUFIP1(gene name)|psi-mi:NUFIP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_036477.2|ensembl:ENSG00000083635(gene)|ensembl:ENST00000379161(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051117"(ATPase binding)|go:"GO:0070761"(pre-snoRNP complex)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR019496|interpro:IPR022755|interpro:IPR039136|mint:Q9UHK0|rcsb pdb:5L85|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|dip:DIP-41010N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:2cxAL+QkWuplLqfjHqqyO4inHio9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9Y2R4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-395458|uniprotkb:Q86YG1|uniprotkb:Q8N213|uniprotkb:Q9NVE0|uniprotkb:Q9Y482|ensembl:ENSP00000479504|ensembl:ENSP00000480030 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ddx52_human(display_long)|uniprotkb:DDX52(gene name)|psi-mi:DDX52(display_short)|uniprotkb:ROK1(gene name synonym)|uniprotkb:DEAD box protein 52(gene name synonym)|uniprotkb:ATP-dependent RNA helicase ROK1-like(gene name synonym)|uniprotkb:HUSSY-19(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_008941.3|ensembl:ENSG00000277594(gene)|ensembl:ENSG00000278053(gene)|ensembl:ENST00000615769(transcript)|ensembl:ENST00000617633(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044764|mint:Q9Y2R4|rcsb pdb:3DKP|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_001278405.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:M3yY9StxHlLGPK0WOqPHwgnmwLU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UEG4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977294|uniprotkb:Q15938|ensembl:ENSP00000262525 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:zn629_human(display_long)|uniprotkb:ZNF629(gene name)|psi-mi:ZNF629(display_short)|uniprotkb:KIAA0326(gene name synonym)|uniprotkb:ZNF65(gene name synonym)|uniprotkb:Zinc finger protein 65(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001073886.1|refseq:NP_001332899.1|ensembl:ENSG00000102870(gene)|ensembl:ENST00000262525(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:EPJvkeWY+5hRyXq62DVXTt0U+I49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9Y4W2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1051591|uniprotkb:Q5JXQ0|uniprotkb:Q8TEN5|uniprotkb:Q9H9V5|uniprotkb:A9X410|ensembl:ENSP00000363944 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:las1l_human(display_long)|uniprotkb:LAS1L(gene name)|psi-mi:LAS1L(display_short)|uniprotkb:Protein LAS1 homolog(gene name synonym)|uniprotkb:MSTP060(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001164120.1|refseq:NP_001164121.1|refseq:NP_112483.1|ensembl:ENSG00000001497(gene)|ensembl:ENST00000374811(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090730"(Las1 complex)|interpro:IPR007174(Las1-like)|mint:Q9Y4W2|reactome:R-HSA-6791226 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:1TTE2TCMIwczNaT2SSMLioLkALA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q5W0B1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2562035|uniprotkb:Q9H8M0|uniprotkb:B2RN99|uniprotkb:Q9H0T2|uniprotkb:Q8TBY2|ensembl:ENSP00000282003 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:obi1_human(display_long)|uniprotkb:OBI1(gene name)|psi-mi:OBI1(display_short)|uniprotkb:C13orf7(gene name synonym)|uniprotkb:RING finger protein 219(gene name synonym)|uniprotkb:RNF219(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_078822.3|ensembl:ENSG00000152193(gene)|ensembl:ENST00000282003(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035691|interpro:IPR039209|mint:Q5W0B1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:MCzyMLZ+OMynQerFlsiwIHPRc0M9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9Y5Q9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1054873|uniprotkb:Q4ZG48|uniprotkb:Q86XJ8|uniprotkb:Q8WX84|uniprotkb:Q96B44|uniprotkb:Q9H5I8|uniprotkb:Q9NT97|intact:EBI-1237212|ensembl:ENSP00000263956 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tf3c3_human(display_long)|uniprotkb:GTF3C3(gene name)|psi-mi:GTF3C3(display_short)|uniprotkb:Transcription factor IIIC subunit gamma(gene name synonym)|uniprotkb:Transcription factor IIIC 102 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001193703.1|refseq:NP_036218.1|ensembl:ENSG00000119041(gene)|ensembl:ENST00000263956(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039340|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:cF53nd62xSXQfZerd7bdfB2KUgk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9BVA1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-355665|uniprotkb:A8K068|ensembl:ENSP00000259818 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tbb2b_human(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_821080.1|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1990403"(embryonic brain development)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BVA1|rcsb pdb:6E7C|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|ensembl:ENST00000259818(transcript)|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-5663220|ensembl:ENSG00000137285(gene) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:sluQMryNuOvp6xlV558+agiRwvE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A0FGR8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-3184170|uniprotkb:Q9ULJ2|uniprotkb:Q9NW47|uniprotkb:Q69YJ2|uniprotkb:Q6ZVU1|uniprotkb:Q6UKI4|uniprotkb:Q6ZTU0|uniprotkb:Q9BQS0|uniprotkb:A4D229 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:esyt2_human(display_long)|uniprotkb:ESYT2(gene name)|psi-mi:ESYT2(display_short)|uniprotkb:FAM62B(gene name synonym)|uniprotkb:KIAA1228(gene name synonym)|uniprotkb:Chr2Syt(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0006897"(endocytosis)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0045296"(cadherin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR031468|interpro:IPR035892|go:"GO:0005789"(endoplasmic reticulum membrane)|interpro:IPR037733|interpro:IPR037749|interpro:IPR037752|interpro:IPR039010|rcsb pdb:2DMG|rcsb pdb:4NPJ|rcsb pdb:4NPK|rcsb pdb:4P42|reactome:R-HSA-1660662|refseq:NP_065779.1|mint:A0FGR8|dip:DIP-61039N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:mOkUWt8oia02xtJYM6gQz3tsav89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UNF1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-725832|uniprotkb:O76058|uniprotkb:Q5BJF3|uniprotkb:Q8NAL6|uniprotkb:Q9H218|uniprotkb:Q9P0U9|uniprotkb:A6NMX0|uniprotkb:Q9UM52|ensembl:ENSP00000218439|ensembl:ENSP00000364193|ensembl:ENSP00000364198|ensembl:ENSP00000364209|ensembl:ENSP00000379526 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:magd2_human(display_long)|uniprotkb:MAGE-D2 antigen(gene name synonym)|uniprotkb:Breast cancer-associated gene 1 protein(gene name synonym)|uniprotkb:11B6(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein JCL-1(gene name synonym)|uniprotkb:MAGED2(gene name)|psi-mi:MAGED2(display_short)|uniprotkb:BCG1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_055414.2|refseq:NP_803182.1|refseq:NP_957516.1|ensembl:ENSG00000102316(gene)|ensembl:ENST00000218439(transcript)|ensembl:ENST00000375053(transcript)|ensembl:ENST00000375058(transcript)|ensembl:ENST00000375068(transcript)|ensembl:ENST00000396224(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0016020"(membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9UNF1|reactome:R-HSA-114608|dip:DIP-50722N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:fXavezmKy58aGuVgzvDYjwNw3B89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9BW92 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UKN8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1237240|uniprotkb:Q5VZJ7|ensembl:ENSP00000361219 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tf3c4_human(display_long)|uniprotkb:GTF3C4(gene name)|psi-mi:GTF3C4(display_short)|uniprotkb:Transcription factor IIIC subunit delta(gene name synonym)|uniprotkb:TF3C-delta(gene name synonym)|uniprotkb:Transcription factor IIIC 90 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_036336.2|ensembl:ENSG00000125484(gene)|ensembl:ENST00000372146(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR024761|interpro:IPR024764|interpro:IPR036322|interpro:IPR044230|mint:Q9UKN8|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:OFldz80WMs7KQ59Of0rkkj80lyc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A0AVN2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977322 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a0avn2_human(display_long)|uniprotkb:BARD1(gene name)|psi-mi:BARD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000456.2|refseq:NP_001269472.1|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036420|interpro:IPR036770|interpro:IPR039503|go:"GO:0016740"(transferase activity)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:HhrhYUAsoqMh0MHxlICYAsz4XUE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UJS0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q8TA92 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977349 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q8ta92_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006787.2|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR027417|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR000642(Peptidase M41)|interpro:IPR037219|interpro:IPR041569|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:NC03XwBER70idywyXGR0JrQBHjA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q7Z7L1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1052253|uniprotkb:Q8N3S8|uniprotkb:Q8N762|uniprotkb:Q8TEE0|uniprotkb:E1P643|ensembl:ENSP00000312402|ensembl:ENSP00000378067 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:sln11_human(display_long)|uniprotkb:SLFN11(gene name)|psi-mi:SLFN11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001098057.1|refseq:NP_001098058.1|refseq:NP_001098059.1|refseq:NP_001098060.1|refseq:NP_689483.3|refseq:XP_011523767.1|refseq:XP_005258125.1|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0010942"(positive regulation of cell death)|ensembl:ENSG00000172716(gene)|go:"GO:0043111"(replication fork arrest)|ensembl:ENST00000308377(transcript)|ensembl:ENST00000394566(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0004386"(helicase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005524"(ATP binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007421(ATPase associated with various cellular activities, AAA-4)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR018647|interpro:IPR027417|interpro:IPR029684|interpro:IPR038461|mint:Q7Z7L1|refseq:XP_006722234.1|refseq:XP_016880788.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:52pyX1VK+Z/vzzmgci5rF+EbQTA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q6I9V5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977335 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q6i9v5_human(display_long)|uniprotkb:SLC25A6(gene name)|psi-mi:SLC25A6(display_short)|uniprotkb:ADP,ATP carrier protein(gene name synonym)|uniprotkb:hCG_1746794(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001627.2|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1990544"(mitochondrial ATP transmembrane transport) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:K5zi7otVqbL4Z4NHyHB1nojLOTg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q8WY91 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-726691|uniprotkb:Q53NU7|uniprotkb:Q6GRN0|uniprotkb:Q6IPJ3|uniprotkb:Q9NW26|uniprotkb:Q9Y325|intact:EBI-28986310|ensembl:ENSP00000385006 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:thap4_human(display_long)|uniprotkb:THAP4(gene name)|psi-mi:THAP4(display_short)|uniprotkb:Ferric Homo sapiens nitrobindin(gene name synonym)|uniprotkb:THAP domain-containing protein 4(gene name synonym)|uniprotkb:CGI-36(orf name)|uniprotkb:PP238(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001157828.1|refseq:NP_057047.4|ensembl:ENST00000402136|ensembl:ENSP00000385931|ensembl:ENSP00000385006|ensembl:ENSG00000176946(gene)|ensembl:ENST00000407315(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0006570"(tyrosine metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0042126"(nitrate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0062213"(peroxynitrite isomerase activity)|go:"GO:0070026"(nitric oxide binding)|interpro:IPR006612(Zinc finger, C2CH-type)|interpro:IPR012674(Calycin)|interpro:IPR014878(Region of unknown function DUF1794)|interpro:IPR038441|rcsb pdb:3IA8 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:q44Yniyo/djCL9rX/tVDwnSBe389606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8K0T9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977422 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8k0t9_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|go:"GO:0003779"(actin binding)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0051016"(barbed-end actin filament capping) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:yxFcTATzQ0qEKNTN+2IaOYWGGIo9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8K8U7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977509 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8k8u7_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:SEHlEnWSPYknKqxhPb0vRoJU3Ns9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A4D210 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977451 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a4d210_human(display_long)|uniprotkb:EIF3S9(gene name)|psi-mi:EIF3S9(display_short)|uniprotkb:EIF3B(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:hCG_1998988(orf name)|uniprotkb:tcag7.544(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR034363|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:XP_011513903.1|interpro:IPR035979|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:DtUxqv0vtZGR+Nf7ZfKVAxNBrvA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q8IXX5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2841953|uniprotkb:A8K5W1|uniprotkb:Q6NW15|uniprotkb:Q96E06|ensembl:ENSP00000356211 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:t183a_human(display_long)|uniprotkb:TMEM183A(gene name)|psi-mi:TMEM183A(display_short)|uniprotkb:C1orf37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_612400.3|ensembl:ENSG00000163444(gene)|ensembl:ENST00000367242(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026509|interpro:IPR036047|mint:Q8IXX5 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:XNJR0b9RbNBEXSE9ohP+TfVtxzM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B1AKY9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977399|ensembl:ENSP00000376066 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b1aky9_human(display_long)|uniprotkb:ATP1A2(gene name)|psi-mi:ATP1A2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000018625(gene)|ensembl:ENST00000392233(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008556"(P-type potassium transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:B1AKY9 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:B6cX4hEl+XvpQ61IT1udrArs5zg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R5Y4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977431 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r5y4_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|go:"GO:0005634"(nucleus) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:SvsIFOZlNEPJE5vu3P9mZs+kuqk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q13765 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-712216|ensembl:ENSP00000349212|ensembl:ENSP00000377469|ensembl:ENSP00000446801|ensembl:ENSP00000447821|ensembl:ENSP00000503345|uniprotkb:Q3KQV4|uniprotkb:Q53A18|uniprotkb:Q53G46|uniprotkb:A8MTN7|uniprotkb:B2R4P8|uniprotkb:F8VU71 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:naca_human(display_long)|uniprotkb:Alpha-NAC(gene name synonym)|uniprotkb:NACA(gene name)|psi-mi:NACA(display_short)|uniprotkb:HSD48(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000196531(gene)|ensembl:ENST00000356769(transcript)|ensembl:ENST00000393891(transcript)|ensembl:ENST00000546392(transcript)|ensembl:ENST00000552540(transcript)|ensembl:ENST00000678066(transcript)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006412"(translation)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0015031"(protein transport)|go:"GO:0042060"(wound healing)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901227"(negative regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:1901228"(positive regulation of transcription from RNA polymerase II promoter involved in heart development)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR044034|mint:Q13765|rcsb pdb:3LKX|rcsb pdb:3MCB|rcsb pdb:3MCE|go:"GO:0043403"(skeletal muscle tissue regeneration)|refseq:NP_001106672.1|refseq:NP_001307122.1|refseq:NP_001307123.1|refseq:NP_005585.1|refseq:NP_001106673.1|refseq:NP_001106674.2|dip:DIP-43878N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:l8QKB8mfSwvDDSSObGLQ7i1LgWo9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P62195 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N - - crc64:29C6410C4A85A7F7 dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B1Q2B0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977473 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b1q2b0_human(display_long)|uniprotkb:URCC5(gene name)|psi-mi:URCC5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR000967(Zinc finger, NF-X1-type)|interpro:IPR001841(Zinc finger, RING-type)|refseq:NP_001265552.1|interpro:IPR034078|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:e4TUO+7KTjGnO0SGLgvmIdYAXc09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8KA19 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977499 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8ka19_human(display_long)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:tRNA exportin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR040017|go:"GO:0000049"(tRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:1JU0SI+DtFuyzBcXVQ4I2TFJSik9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B0QY89 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2510460|ensembl:ENSP00000416892|uniprotkb:E9PB84 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b0qy89_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|ensembl:ENSG00000100129(gene)|ensembl:ENST00000412331(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:9Ig8GRbf2Y8j+VQkYFQqTU1k41A9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8K781 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977386 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8k781_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|interpro:IPR035254|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:wI/3slqJ4T1rgcNh3F55Qg1UgVo9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B1ANR0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977484|ensembl:ENSP00000361953 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b1anr0_human(display_long)|uniprotkb:PABPC4(gene name)|psi-mi:PABPC4(display_short)|uniprotkb:hCG_2031827(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000090621(gene)|ensembl:ENST00000372862(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:lStIyupVoR9Mly5sLWTobmGAZUk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R5W2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9512830|ensembl:ENSP00000404559 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r5w2_human(display_long)|uniprotkb:HNRNPC(gene name)|psi-mi:HNRNPC(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000092199(gene)|ensembl:ENST00000449098(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR035979 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:mw5fsmHFd1vShnA7PPP6bZDT0Qs9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8K2R3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977437 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8k2r3_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002937(Amine oxidase)|interpro:IPR017366(Histone lysine-specific demethylase)|interpro:IPR009057(Homeodomain-like)|interpro:IPR007526(SWIRM)|interpro:IPR036188|interpro:IPR036388|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0050660"(flavin adenine dinucleotide binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:joZ6XVzrZhAXKpNJQUXV78G+VB89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A8K5I0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-3930998 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a8k5i0_human(display_long)|uniprotkb:HEL-S-103(gene name)|psi-mi:HEL-S-103(display_short)|uniprotkb:HSPA1A(gene name synonym)|uniprotkb:HSPA1B(gene name synonym)|uniprotkb:hCG_1820593(orf name)|uniprotkb:hCG_43726(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR043129|go:"GO:0005524"(ATP binding)|refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q5C9Z4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2685618|uniprotkb:Q96I08|ensembl:ENSP00000275820 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:nom1_human(display_long)|uniprotkb:C7orf3(gene name synonym)|uniprotkb:SGD1 homolog(gene name synonym)|uniprotkb:NOM1(gene name)|psi-mi:NOM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_612409.1|ensembl:ENSG00000146909(gene)|ensembl:ENST00000275820(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0048820"(hair follicle maturation)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:Q5C9Z4 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:1LScd95yytIZJ1/UFg9WTUiCmqg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q08945 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P04264 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-298429|uniprotkb:Q14720|uniprotkb:Q6GSJ0|uniprotkb:B2RA01|uniprotkb:Q9H298|ensembl:ENSP00000252244|uniprotkb:P85925|uniprotkb:P86104 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:k2c1_human(display_long)|uniprotkb:KRT1(gene name)|psi-mi:KRT1(display_short)|uniprotkb:KRTA(gene name synonym)|uniprotkb:Keratin-1(gene name synonym)|uniprotkb:Cytokeratin-1(gene name synonym)|uniprotkb:67 kDa cytokeratin(gene name synonym)|uniprotkb:Hair alpha protein(gene name synonym)|uniprotkb:Type-II keratin Kb1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006112.3|ensembl:ENSG00000167768(gene)|ensembl:ENST00000252244(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045095"(keratin filament)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR032449|interpro:IPR039008|mint:P04264|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6UUI|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:TeAC3i2hWTS2lgXT0i4agp9nv349606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O14654 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O94826 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q8NE71 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-720571|uniprotkb:A2BF75|uniprotkb:O14897|uniprotkb:Q69YP6|ensembl:ENSP00000313603|ensembl:ENSP00000373082|ensembl:ENSP00000389065|ensembl:ENSP00000411327|ensembl:ENSP00000412553|ensembl:ENSP00000413319|ensembl:ENSP00000414373 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:abcf1_human(display_long)|uniprotkb:ATP-binding cassette 50(gene name synonym)|uniprotkb:TNF-alpha-stimulated ABC protein(gene name synonym)|uniprotkb:ABCF1(gene name)|psi-mi:ABCF1(display_short)|uniprotkb:ABC50(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001020262.1|refseq:NP_001081.1|dip:DIP-50666N|ensembl:ENSG00000204574(gene)|ensembl:ENSG00000206490(gene)|ensembl:ENSG00000225989(gene)|ensembl:ENSG00000231129(gene)|ensembl:ENSG00000232169(gene)|ensembl:ENSG00000236149(gene)|ensembl:ENSG00000236342(gene)|ensembl:ENST00000326195(transcript)|ensembl:ENST00000383588(transcript)|ensembl:ENST00000419893(transcript)|ensembl:ENST00000423247(transcript)|ensembl:ENST00000426219(transcript)|ensembl:ENST00000457078(transcript)|ensembl:ENST00000457111(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008494"(translation activator activity)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR027417|mint:Q8NE71|rcsb pdb:5ZXD|reactome:R-HSA-382556 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:DdEbnAZo4bv75DRSzSmcdNo6QsM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q6IBW4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2548296|ensembl:ENSP00000410088|uniprotkb:Q9BUT3|uniprotkb:Q9BVD1|uniprotkb:B7WPH1|uniprotkb:O43788|uniprotkb:Q13391|uniprotkb:Q96C14|uniprotkb:Q96GJ0|uniprotkb:Q9BQ71 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:cndh2_human(display_long)|uniprotkb:NCAPH2(gene name)|psi-mi:NCAPH2(display_short)|uniprotkb:CAPH2(gene name synonym)|uniprotkb:Non-SMC condensin II complex subunit H2(gene name synonym)|uniprotkb:Chromosome-associated protein H2(gene name synonym)|uniprotkb:Kleisin-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000025770(gene)|ensembl:ENST00000420993(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051309"(female meiosis chromosome separation)|interpro:IPR009378(Protein of unknown function DUF1032)|interpro:IPR031719|interpro:IPR031737|interpro:IPR031739|mint:Q6IBW4|reactome:R-HSA-2299718|refseq:NP_001171940.1|refseq:NP_055366.3|refseq:NP_689512.2|dip:DIP-43901N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:GTOZg0OoAHm+tj3C8/3sCGM+G5E9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00257 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-722425|uniprotkb:Q96C04|uniprotkb:Q6TPI8|uniprotkb:B1PJR7|ensembl:ENSP00000269397 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:cbx4_human(display_long)|uniprotkb:Chromobox protein homolog 4(gene name synonym)|uniprotkb:Polycomb 2 homolog(gene name synonym)|uniprotkb:CBX4(gene name)|psi-mi:CBX4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_003646.2|dip:DIP-42042N|ensembl:ENSG00000141582(gene)|ensembl:ENST00000269397(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032183"(SUMO binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0061665"(SUMO ligase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR043531|mint:O00257|rcsb pdb:2K28|rcsb pdb:3I8Z|rcsb pdb:5EPL|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:uHX633+6nZPTNHOPmUKK+zW/b4Q9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:A4D110 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978194 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:a4d110_human(display_long)|uniprotkb:LOC401309(gene name)|psi-mi:LOC401309(display_short)|uniprotkb:tcag7.949(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:RKxCH9JtTeX5LqThR82X/1ohRjM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KNN7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977587 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3knn7_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035267|interpro:IPR036390|go:"GO:0000502"(proteasome complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:AatMCQW60rZuIDjEEwUtnaQx/UU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P62333 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q1ED39 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977982|uniprotkb:O43328|uniprotkb:Q5FWF3|ensembl:ENSP00000219837 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:knop1_human(display_long)|uniprotkb:KNOP1(gene name)|psi-mi:KNOP1(display_short)|uniprotkb:C16orf88(gene name synonym)|uniprotkb:FAM191A(gene name synonym)|uniprotkb:TSG118(gene name synonym)|uniprotkb:Protein FAM191A(gene name synonym)|uniprotkb:Testis-specific gene 118 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001013009.2|refseq:NP_001335457.1|refseq:NP_001335458.1|refseq:NP_001335459.1|refseq:NP_001335460.1|ensembl:ENSG00000103550(gene)|ensembl:ENST00000219837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|interpro:IPR028124 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:DbTowYDo0km0cUlAS8TTL5JIyyQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P09874 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P52597 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-352986|ensembl:ENSP00000338477|ensembl:ENSP00000349573|ensembl:ENSP00000400433|ensembl:ENSP00000438061|ensembl:ENSP00000507787|ensembl:ENSP00000348345|uniprotkb:Q5T0N2|uniprotkb:Q96AU2|uniprotkb:B3KM84 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hnrpf_human(display_long)|uniprotkb:HNRNPF(gene name)|psi-mi:HNRNPF(display_short)|uniprotkb:HNRPF(gene name synonym)|uniprotkb:Nucleolin-like protein mcs94-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P52597|rcsb pdb:2HGL|rcsb pdb:2HGM|rcsb pdb:2HGN|rcsb pdb:2KFY|rcsb pdb:2KG0|rcsb pdb:2KG1|rcsb pdb:3TFY|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000169813(gene)|ensembl:ENST00000337970(transcript)|ensembl:ENST00000356053(transcript)|ensembl:ENST00000357065(transcript)|ensembl:ENST00000443950(transcript)|ensembl:ENST00000544000(transcript)|ensembl:ENST00000682386(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_001091674.1|refseq:NP_001091675.1|refseq:NP_001091676.1|refseq:NP_001091677.1|refseq:NP_001091678.1|refseq:NP_004957.1|dip:DIP-33145N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:pblzpldZOa5vlZ+zGQY9qyWCxaw9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P22626 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-299649|ensembl:ENSP00000346694|ensembl:ENSP00000349101|ensembl:ENSP00000354021|ensembl:ENSP00000503360|ensembl:ENSP00000503476|ensembl:ENSP00000503514|ensembl:ENSP00000503885|ensembl:ENSP00000504329|uniprotkb:P22627|uniprotkb:A8K064|uniprotkb:Q9UC98|uniprotkb:Q9UDJ2|uniprotkb:A0A024RA27|uniprotkb:A0A024RA61 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:roa2_human(display_long)|uniprotkb:HNRNPA2B1(gene name)|psi-mi:HNRNPA2B1(display_short)|uniprotkb:HNRPA2B1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|ensembl:ENST00000679001(transcript)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0050658"(RNA transport)|ensembl:ENST00000679021(transcript)|go:"GO:0070062"(extracellular exosome)|ensembl:ENST00000679123(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|go:"GO:1990428"(miRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034486|interpro:IPR034489|interpro:IPR035979|mint:P22626|rcsb pdb:1X4B|rcsb pdb:5EN1|rcsb pdb:5HO4|rcsb pdb:5WWE|rcsb pdb:5WWF|rcsb pdb:5WWG|rcsb pdb:6WPQ|rcsb pdb:6WQK|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-8950505|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|ensembl:ENSG00000122566(gene)|ensembl:ENST00000354667(transcript)|ensembl:ENST00000356674(transcript)|ensembl:ENST00000360787(transcript)|ensembl:ENST00000676746(transcript)|ensembl:ENST00000678675(transcript)|refseq:NP_002128.1|refseq:NP_112533.1|dip:DIP-32877N|refseq:XP_005249786.1|refseq:XP_016867598.1|refseq:XP_016867599.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:N2NeJVio9eYQULNcdE1KXtd2KPw9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O75616 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-6393536|ensembl:ENSP00000254928|uniprotkb:B3KN21|uniprotkb:C9JEC6|uniprotkb:O75617|uniprotkb:Q8WUY4|uniprotkb:Q96LE2|uniprotkb:Q96TC0 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:eral1_human(display_long)|uniprotkb:ERAL1(gene name)|psi-mi:ERAL1(display_short)|uniprotkb:HERA(gene name synonym)|uniprotkb:Conserved ERA-like GTPase(gene name synonym)|uniprotkb:ERA-W(gene name synonym)|uniprotkb:ERA-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000132591(gene)|ensembl:ENST00000254928(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0043024"(ribosomal small subunit binding)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005662(GTP-binding protein Era)|interpro:IPR006073(GTP1/OBG)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR027417|interpro:IPR030388|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_005693.1|refseq:NP_001304914.1|refseq:NP_001304915.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:2usCrRc4/GbXG5Ft8GY61w+rGds9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00567 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-396034|uniprotkb:Q2M3T6|uniprotkb:Q9NQ05|ensembl:ENSP00000370589 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:nop56_human(display_long)|uniprotkb:NOP56(gene name)|psi-mi:NOP56(display_short)|uniprotkb:NOL5A(gene name synonym)|uniprotkb:Nucleolar protein 5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006383.2|ensembl:ENSG00000101361(gene)|ensembl:ENST00000329276(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|interpro:IPR012974(NOP5, N-terminal)|interpro:IPR012976(NOSIC)|interpro:IPR036070|interpro:IPR042239|mint:O00567|reactome:R-HSA-390471|reactome:R-HSA-6790901|reactome:R-HSA-6791226 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:nXIsxj5Spl+kflK0yGJFykVylmA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q3ZCQ8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q53SS8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978003 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q53ss8_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:HEL-S-85(gene name synonym)|uniprotkb:hCG_1776997(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|refseq:NP_006187.2|interpro:IPR036612|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0098847"(sequence-specific single stranded DNA binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P19784 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-347451|ensembl:ENSP00000262506 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q59EY3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978013 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q59ey3_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:jGzZT03Vyor1diXNSOugkHWsRu09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O60884 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q16637 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-395421|uniprotkb:Q13119|uniprotkb:Q549U5|uniprotkb:Q96J51|ensembl:ENSP00000305857|uniprotkb:A8K0V4|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENSP00000370119|ensembl:ENSP00000479920|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:smn_human(display_long)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000335.1|refseq:NP_059107.1|refseq:NP_075012.1|refseq:NP_075013.1|refseq:NP_075014.1|refseq:NP_075015.1|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007399"(nervous system development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:Q16637|rcsb pdb:1G5V|rcsb pdb:1MHN|rcsb pdb:2LEH|rcsb pdb:4A4E|rcsb pdb:4A4G|rcsb pdb:4GLI|rcsb pdb:4QQ6|rcsb pdb:5XJL|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|go:"GO:0032797"(SMN complex)|refseq:NP_001284644.1|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENST00000380742|ensembl:ENSP00000370118|ensembl:ENSP00000370119|ensembl:ENST00000503079|ensembl:ENSP00000428128|ensembl:ENST00000506163|ensembl:ENSP00000424926|ensembl:ENST00000611442|ensembl:ENSP00000483768|ensembl:ENST00000614240|ensembl:ENSP00000479279|ensembl:ENSP00000479920|ensembl:ENST00000614773|ensembl:ENSP00000481427|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENST00000622158|ensembl:ENSP00000480906|ensembl:ENSP00000482966|ensembl:ENST00000624634|ensembl:ENSP00000485595|ensembl:ENST00000626847|ensembl:ENSP00000486152|ensembl:ENSP00000487421|ensembl:ENST00000628353|ensembl:ENSP00000487029|ensembl:ENST00000628642|ensembl:ENSP00000487015|ensembl:ENSP00000487206|refseq:XP_016865275.1|dip:DIP-31309N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P61964 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P52272 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00410 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q2TSD0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978064 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q2tsd0_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR020831|interpro:IPR020830|interpro:IPR020829|interpro:IPR020828|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR036291|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:fdkbHG+Q0VEDi2fG5z5uM3mJEAU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P09543 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1059219|intact:EBI-1188262|ensembl:ENSP00000377470 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:cn37_human(display_long)|uniprotkb:CNP(gene name)|psi-mi:CNP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_149124.3|refseq:XP_011522642.1|ensembl:ENSG00000173786(gene)|ensembl:ENST00000393892(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004113"(2',3'-cyclic-nucleotide 3'-phosphodiesterase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009214"(cyclic nucleotide catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031143"(pseudopodium)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042470"(melanosome)|go:"GO:0045202"(synapse)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008431(Cyclic nucleotide phosphodiesterase)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR027417|mint:P09543|rcsb pdb:1WOJ|go:"GO:0003723"(RNA binding)|refseq:NP_001317145.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:TpzVM789s3qQKK7B00Vo92s31bY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q53XC0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978030 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q53xc0_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)|uniprotkb:hCG_21909(orf name)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004085.1|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR003029(S1, RNA binding)|interpro:IPR022967|interpro:IPR024055|interpro:IPR024054|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR044126|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q8WVD3 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-749039|uniprotkb:Q9H8K2|uniprotkb:Q9UF87|uniprotkb:Q9UKI6|uniprotkb:B2RE17|ensembl:ENSP00000261593 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:rn138_human(display_long)|uniprotkb:RING finger protein 138(gene name synonym)|uniprotkb:Nemo-like kinase-associated RING finger protein(gene name synonym)|uniprotkb:RNF138(gene name)|psi-mi:RNF138(display_short)|uniprotkb:NARF(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF138(gene name synonym)|uniprotkb:HSD-4(orf name)|uniprotkb:HSD4(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_057355.2|refseq:NP_937761.1|refseq:NP_001178253.2|refseq:XP_005258343.1|ensembl:ENSG00000134758(gene)|ensembl:ENST00000261593(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034734|reactome:R-HSA-983168 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:HhGscRenFoqXTiZxHR62E4wcIo09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O60256 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-724960|uniprotkb:B7ZKZ1|uniprotkb:Q6IAS2|ensembl:ENSP00000268835|uniprotkb:B4E1M8|uniprotkb:E7EMY2|uniprotkb:B4E329 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:kprb_human(display_long)|uniprotkb:41 kDa phosphoribosypyrophosphate synthetase-associated protein(gene name synonym)|uniprotkb:PRPSAP2(gene name)|psi-mi:PRPSAP2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002758.1|refseq:NP_001230865.1|refseq:NP_001230869.1|refseq:NP_001230870.1|refseq:NP_001230871.1|ensembl:ENSG00000141127(gene)|ensembl:ENST00000268835(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099|rcsb pdb:2JI4|refseq:XP_005256782.1|refseq:XP_005256783.1|refseq:XP_005256786.1|refseq:XP_016880354.1|refseq:XP_016880355.1|refseq:XP_016880356.1|refseq:XP_016880360.1|refseq:XP_016880361.1|refseq:XP_016880362.1|refseq:XP_016880363.1|refseq:XP_016880364.1|refseq:XP_016880365.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:6sFkRIePKX0zxDEtLbuXM3gPcFQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P17987 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q15645 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-358993|uniprotkb:C9K0T3|uniprotkb:O15324|ensembl:ENSP00000166345|uniprotkb:D3DTC0 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pch2_human(display_long)|uniprotkb:TRIP13(gene name)|psi-mi:TRIP13(display_short)|uniprotkb:Thyroid receptor-interacting protein 13(gene name synonym)|uniprotkb:PCH2(gene name synonym)|uniprotkb:Thyroid hormone receptor interactor 13(gene name synonym)|uniprotkb:Human papillomavirus type 16 E1 protein-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004228.1|ensembl:ENSG00000071539(gene)|ensembl:ENST00000166345(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_011512465.1|dip:DIP-34493N|go:"GO:0005694"(chromosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR044539|mint:Q15645|rcsb pdb:5VQ9|rcsb pdb:5VQA|rcsb pdb:5WC2|rcsb pdb:6F0X|rcsb pdb:6LK0|rcsb pdb:7L9P - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:heF2f3R2lGIpZ80mZHnhMktXTE49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P41091 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1054228|uniprotkb:B5BTZ4|intact:EBI-11602611|uniprotkb:A0A024RBY4|uniprotkb:A8K2Y2|uniprotkb:B2R5N2|uniprotkb:Q53HK3|ensembl:ENSP00000253039 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:if2g_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit gamma X(gene name synonym)|uniprotkb:EIF2S3(gene name)|psi-mi:EIF2S3(display_short)|uniprotkb:EIF2G(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001406.1|ensembl:ENSG00000130741(gene)|ensembl:ENST00000253039(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR044127|interpro:IPR044128|rcsb pdb:6FEC|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|interpro:IPR027417 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:6uBTiGTvEKMfS0NqkKGIaSR61j89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q2M1J6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978021 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q2m1j6_human(display_long)|uniprotkb:OXA1L(gene name)|psi-mi:OXA1L(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR028055|interpro:IPR001708(60 kDa inner membrane insertion protein)|refseq:NP_005006.3|go:"GO:0016021"(integral component of membrane)|go:"GO:0032977"(membrane insertase activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:C0NxoXoNOdWken8lq2YJb2k8V3M9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00159 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-350423|uniprotkb:Q6NVJ7|intact:EBI-1045431|uniprotkb:Q86Y95|uniprotkb:Q4LE56|ensembl:ENSP00000496954 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:myo1c_human(display_long)|uniprotkb:MYO1C(gene name)|psi-mi:MYO1C(display_short)|uniprotkb:Myosin I beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006605"(protein targeting)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0005829"(cytosol)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|refseq:NP_001074248.1|refseq:NP_001074419.1|refseq:NP_203693.3|ensembl:ENSG00000197879(gene)|ensembl:ENST00000648651(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:O00159|rcsb pdb:4BYF|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-5250924|reactome:R-HSA-9662360|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|reactome:R-HSA-9662361|reactome:R-HSA-9664422|dip:DIP-33109N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:g6wQN0OVKjd3T1kOebWFcqWNzNA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O43663 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-741137|ensembl:ENSP00000377793|uniprotkb:Q9BSB6|uniprotkb:A6NC44|uniprotkb:B4DLR1|intact:EBI-11127601|uniprotkb:H9KV59 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:prc1_human(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_003972.1|ensembl:ENSG00000198901(gene)|ensembl:ENST00000394249(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0070938"(contractile ring)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR007145(MAP65/ASE1)|interpro:IPR032921|mint:O43663|rcsb pdb:3NRX|rcsb pdb:3NRY|rcsb pdb:4L3I|rcsb pdb:4L6Y|rcsb pdb:5KMG|reactome:R-HSA-5625900|go:"GO:0019894"(kinesin binding)|refseq:NP_001254509.1|dip:DIP-34436N - - crc64:28393C5B1B3662F3 dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:AV2d6TYVsFn2J598pi/GmPdgK7A9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P10589 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2795168|ensembl:ENSP00000325819 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:cot1_human(display_long)|uniprotkb:NR2F1(gene name)|psi-mi:NR2F1(display_short)|uniprotkb:EAR3(gene name synonym)|uniprotkb:ERBAL3(gene name synonym)|uniprotkb:TFCOUP1(gene name synonym)|uniprotkb:COUP transcription factor I(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 1(gene name synonym)|uniprotkb:V-erbA-related protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_005645.1|ensembl:ENSG00000175745(gene)|ensembl:ENST00000327111(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:2EBL|reactome:R-HSA-383280|dip:DIP-622N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Vtb/tYDWhdctLd4ZsYtYyCRhfb49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P61221 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q562V5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978048 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q562v5_human(display_long)|uniprotkb:ACT(gene name)|psi-mi:ACT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:4N94wPPxhwiaFz9cOs2qFWgLnhE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P04075 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q14558 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-724449|uniprotkb:Q96H06|uniprotkb:B2R6M4 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:kpra_human(display_long)|uniprotkb:39 kDa phosphoribosypyrophosphate synthase-associated protein(gene name synonym)|uniprotkb:PRPSAP1(gene name)|psi-mi:PRPSAP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002757.2|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|rcsb pdb:2C4K|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR029057|interpro:IPR029099 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:7kFJX6q/3EcGnRNgAOImlr93Xys9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q07065 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O00231 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P31943 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q1KLZ0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978131 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q1klz0_human(display_long)|uniprotkb:PS1TP5BP1(gene name)|psi-mi:PS1TP5BP1(display_short)|uniprotkb:hCG_15971(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001092.1|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q0QEN7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978111 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q0qen7_human(display_long)|uniprotkb:ATP5B(gene name)|psi-mi:ATP5B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR020003|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|go:"GO:0005524"(ATP binding)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:yJwE3II2ph+GDwXLxJlmFhinftY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9NVI7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q2I0Y7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9978054 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q2i0y7_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:89AxVaVzaUA83UtVqJVFRaxogs89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O15269 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1044323|uniprotkb:Q5VWB4|uniprotkb:A8K681|uniprotkb:Q96IX6|ensembl:ENSP00000262554 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:sptc1_human(display_long)|uniprotkb:Serine-palmitoyl-CoA transferase 1(gene name synonym)|uniprotkb:Long chain base biosynthesis protein 1(gene name synonym)|uniprotkb:SPTLC1(gene name)|psi-mi:SPTLC1(display_short)|uniprotkb:LCB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_006406.1|refseq:NP_847894.1|refseq:NP_001268232.1|ensembl:ENSG00000090054(gene)|ensembl:ENST00000262554(transcript)|go:"GO:0004758"(serine C-palmitoyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017059"(serine C-palmitoyltransferase complex)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0035339"(SPOTS complex)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904649"(regulation of fat cell apoptotic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|mint:O15269|rcsb pdb:6M4N|rcsb pdb:6M4O|rcsb pdb:7CQI|rcsb pdb:7CQK|rcsb pdb:7K0I|rcsb pdb:7K0J|rcsb pdb:7K0K|rcsb pdb:7K0L|rcsb pdb:7K0M|rcsb pdb:7K0N|rcsb pdb:7K0O|rcsb pdb:7K0P|rcsb pdb:7K0Q|reactome:R-HSA-1660661|dip:DIP-45626N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:M/O7lbdRcUwB+r1wpHj2EtSD+kI9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P0C0S8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O75319 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-719569|uniprotkb:Q6AI47|uniprotkb:Q9BWE3|uniprotkb:B2RCT8|ensembl:ENSP00000272444|uniprotkb:C9JYA6 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:dus11_human(display_long)|uniprotkb:Phosphatase that interacts with RNA/RNP complex 1(gene name synonym)|uniprotkb:Dual specificity protein phosphatase 11(gene name synonym)|uniprotkb:DUSP11(gene name)|psi-mi:DUSP11(display_short)|uniprotkb:PIR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_003575.2|ensembl:ENSG00000144048(gene)|ensembl:ENST00000272444(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004651"(polynucleotide 5'-phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0098507"(polynucleotide 5' dephosphorylation)|go:"GO:0098519"(nucleotide phosphatase activity, acting on free nucleotides)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|mint:O75319|rcsb pdb:4JMJ|rcsb pdb:4MBB|rcsb pdb:4NYH - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:6JgkXF0kxfddkDl+sU/A4v/4ObQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P55084 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:O95470 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1046170|uniprotkb:Q7Z732|uniprotkb:Q9ULG8|uniprotkb:Q9UN89|uniprotkb:B2RBD4|ensembl:ENSP00000362298 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:sgpl1_human(display_long)|uniprotkb:Sphingosine-1-phosphate aldolase(gene name synonym)|uniprotkb:SGPL1(gene name)|psi-mi:SGPL1(display_short)|uniprotkb:KIAA1252(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_003892.2|refseq:XP_011538618.1|refseq:XP_011538619.1|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|ensembl:ENSG00000166224(gene)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENST00000373202(transcript)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|go:"GO:0001553"(luteinization)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008117"(sphinganine-1-phosphate aldolase activity)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:4Q6R|reactome:R-HSA-1660661|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|refseq:XP_005270320.1 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hGut7nnomGA7QJhsV4lHBNm+kEE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q16342 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-359462|uniprotkb:Q9UH12|uniprotkb:E9PCU7|uniprotkb:F5GYS7|ensembl:ENSP00000439467|uniprotkb:Q58HM9|uniprotkb:Q58HN0 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pdcd2_human(display_long)|uniprotkb:PDCD2(gene name)|psi-mi:PDCD2(display_short)|uniprotkb:RP8(gene name synonym)|uniprotkb:ZMYND7(gene name synonym)|uniprotkb:Zinc finger protein Rp-8(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_002589.2|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|mint:Q16342|ensembl:ENSG00000071994(gene)|ensembl:ENST00000541970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|refseq:NP_001186392.1|refseq:NP_001186393.1|refseq:NP_001186391.1|refseq:NP_659005.1|dip:DIP-27594N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:I44GXBUa4NByhkP4HQdnUgfkNCs9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R6F9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977560 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r6f9_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:bu/URutAa73ZLvRzcZ8YCalX17Y9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KM81 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977572 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3km81_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001128582.1|refseq:NP_001273445.1|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR036410|interpro:IPR036869|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:aGZAJAXYR8whHopoAJnB+OZ4Fa49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RBI0 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977682 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rbi0_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR026055|interpro:IPR013120(Male sterility, NAD-binding)|refseq:NP_001258712.1|refseq:NP_060569.3|interpro:IPR033640|interpro:IPR036291|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0080019"("fatty-acyl-CoA reductase (alcohol-forming) activity")|go:"GO:0102965"(alcohol-forming fatty acyl-CoA reductase activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3P4DS5mN+oxr1V58KfSi06yNBEk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R806 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977541 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r806_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:INT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036390|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/U3pn1qWNdyk/ZNV9nWoOUb9zYU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RDG1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977657 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rdg1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR026055|interpro:IPR013120(Male sterility, NAD-binding)|interpro:IPR033640|interpro:IPR036291|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0080019"("fatty-acyl-CoA reductase (alcohol-forming) activity")|go:"GO:0102965"(alcohol-forming fatty acyl-CoA reductase activity)|go:"GO:0016021"(integral component of membrane) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:SAMOOOjwA9JVggYOl2NQ6jpA8h49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RBS8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977605 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rbs8_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR000264(Serum albumin)|interpro:IPR020858|interpro:IPR021177|interpro:IPR020857|interpro:IPR014760(Serum albumin, N-terminal)|go:"GO:0005615"(extracellular space)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:12reAA0d46MIwn/F6ax5RmSfr6s9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RAX6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977664 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rax6_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:ffumREoCRwly62mH2LkctISESeY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KPC1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977671 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3kpc1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR038069|interpro:IPR042226|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:vaPJzuxSs62oykmYeWV1xWiykOE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RDW1 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2339597|uniprotkb:D6W5C9 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rdw1_human(display_long)|uniprotkb:HEL112(gene name)|psi-mi:HEL112(display_short)|uniprotkb:RPS27A(gene name synonym)|uniprotkb:Ubiquitin carboxyl extension protein 80(gene name synonym)|uniprotkb:Ubiquitin-40S ribosomal protein S27a(gene name synonym)|uniprotkb:hCG_1987923(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001129064.1|refseq:NP_001170884.1|refseq:NP_002945.1|interpro:IPR002906(Ribosomal protein S27a)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR038582|interpro:IPR029071|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:2LSJafy6vjKHYZcZVx8zZaOXRis9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R7C5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977641 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r7c5_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR018525|interpro:IPR001208(MCM)|interpro:IPR027925|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR027417|interpro:IPR033762|interpro:IPR031327|interpro:IPR041562|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0042555"(MCM complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:wWfN+1aUmz6Twg69lrX1l3o53as9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9Y2X9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-396200|uniprotkb:Q9NY92|uniprotkb:A6NF48|uniprotkb:B3KMX2|uniprotkb:Q5RKW5|intact:EBI-11018373|ensembl:ENSP00000294740|ensembl:ENSP00000356322 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:zn281_human(display_long)|uniprotkb:ZNF281(gene name)|psi-mi:ZNF281(display_short)|uniprotkb:GZP1(gene name synonym)|uniprotkb:ZBP99(gene name synonym)|uniprotkb:Zinc finger DNA-binding protein 99(gene name synonym)|uniprotkb:Transcription factor ZBP-99(gene name synonym)|uniprotkb:GC-box-binding zinc finger protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_036614.1|refseq:NP_001268222.1|refseq:NP_001268223.1|refseq:XP_016856376.1|refseq:XP_016856377.1|ensembl:ENSG00000162702(gene)|ensembl:ENST00000294740(transcript)|ensembl:ENST00000367353(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9Y2X9 - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:bjmz9ne6FkC0kbJUv13u8IoDYHM9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9UHB6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-351479|uniprotkb:Q2TAN7|uniprotkb:Q9BVF2|uniprotkb:Q9H8J1|uniprotkb:Q9HBN5|uniprotkb:Q9NX96|uniprotkb:Q9NXC3|uniprotkb:Q9NXU6|uniprotkb:Q9P0H8|uniprotkb:Q9UHB5|uniprotkb:B2RB09|ensembl:ENSP00000340184|uniprotkb:Q59FE8 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:lima1_human(display_long)|uniprotkb:PP624(orf name)|uniprotkb:LIMA1(gene name)|psi-mi:LIMA1(display_short)|uniprotkb:SREBP3(gene name synonym)|uniprotkb:Epithelial protein lost in neoplasm(gene name synonym)|uniprotkb:EPLIN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001107018.1|refseq:NP_001107019.1|refseq:NP_057441.1|refseq:XP_011536757.1|ensembl:ENSG00000050405(gene)|ensembl:ENST00000341247(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0031526"(brush border membrane)|go:"GO:0031529"(ruffle organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028740|mint:Q9UHB6|rcsb pdb:2D8Y|refseq:NP_001230704.1|refseq:XP_016874919.1|dip:DIP-29633N - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:sHqhe21LVzLJXgDMH6IcWukKNHE9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R6X5 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977532 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r6x5_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129|go:"GO:0005524"(ATP binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:PyOfve8bPEvlkK/XHYi4odRRMgU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RBR9 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9512631 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rbr9_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR000225(Armadillo)|interpro:IPR040122|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3AWYgPEZ95Z9u8iCMflQ3CEGoyk9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RAR2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977615 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rar2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR014881("Nin one binding (NOB1) Zn-ribbon like")|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR033411|interpro:IPR033461|interpro:IPR039907|interpro:IPR017117(D-site 20S pre-rRNA nuclease)|interpro:IPR036283|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:ulk81SK4/3F/vhI5ptd6rOeAIK89606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RDI7 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977628 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rdi7_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR039739|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:/zZuQk25Kid5wPV8C3jHBfYFeQY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RMQ4 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977598 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rmq4_human(display_long)|uniprotkb:CKAP2(gene name)|psi-mi:CKAP2(display_short)|uniprotkb:hCG_1743134(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR029197|interpro:IPR026165|go:"GO:0005737"(cytoplasm) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:DU+SZzBI2SMxNdoGQQ2AldO3oDc9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2RD09 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977635 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2rd09_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR001678("Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p")|interpro:IPR023267|interpro:IPR029063|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0008168"(methyltransferase activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:HTkzCa9xmM5D5UfvrV8Bvcn55549606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B3KP95 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977621 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b3kp95_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR002562(3'-5' exonuclease)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|go:"GO:0003676"(nucleic acid binding)|go:"GO:0008408"(3'-5' exonuclease activity) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:mKZytAY04yhd01qoHcmaOOoSkAQ9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q9BPX6 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q14145 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:B2R7J8 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-9977691 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:b2r7j8_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:JGzpxdZmgzDUhfp4BybHDOoP1E49606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:Q96EY1-2 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-3952284|ensembl:ENSP00000347445|ensembl:ENSP00000479815 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:q96ey1-2(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:HCA57(gene name synonym)|uniprotkb:TID1(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:"Tid-1(S)"(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9976880|imex:IM-23248-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 intact:EBI-356767(isoform-parent)|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000355296(transcript)|ensembl:ENST00000614397(transcript)|uniprotkb:Q96EY1-2(isoform-parent) - - - dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2019/07/06 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:vUs6QuX7N1lqIy87Hp7RaF1+URY9606 intact-crc:1D684D71FE95DD6E|rigid:q9u6PFXg5E/t6oMPuXtMaYytxoU false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75807 uniprotkb:P62136 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0096"(pull down) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9978212|imex:IM-23248-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - comment:The C-terminal PPP1R15A domain, 514-674, selectively associated with a 35 kDa proteolyzed form of TARDBP|figure legend:Fig. 4C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/28 2018/05/03 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:DCE46ECE9481F2C7|rigid:VbHahvogOYQuwLx+056LDFRKpNA false glutathione s tranferase tag:n-n|sufficient binding region:241-674 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:P05198 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9978212|imex:IM-23248-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N - - - comment:The C-terminal PPP1R15A domain, 514-674, selectively associated with a 35 kDa proteolyzed form of TARDBP|figure legend:Fig. 4C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/28 2018/05/03 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606 intact-crc:DCE46ECE9481F2C7|rigid:VbHahvogOYQuwLx+056LDFRKpNA false glutathione s tranferase tag:n-n|sufficient binding region:241-674 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0096"(pull down) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9978212|imex:IM-23248-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - comment:The C-terminal PPP1R15A domain, 514-674, selectively associated with a 35 kDa proteolyzed form of TARDBP|figure legend:Fig. 4C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/28 2018/05/03 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:DCE46ECE9481F2C7|rigid:VbHahvogOYQuwLx+056LDFRKpNA false glutathione s tranferase tag:n-n|sufficient binding region:241-674 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:P62136 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979030|imex:IM-23248-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - figure legend:Fig. 2A, 2B, 2C|comment:"GADD34/TDP-43 and to a lesser extent eIF2A binding was induced by arsenite, PPP1CA was not. Exposure to N-acetylcysteine (NAC), an anti-oxidant, inhibited arsenite-induced GADD34/TDP-43 binding in a dose-dependent manner had no impact on GADD34 binding to either PP1CA or eIF2A."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:8E1C071AE08142CD|rigid:VbHahvogOYQuwLx+056LDFRKpNA false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979030|imex:IM-23248-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - figure legend:Fig. 2A, 2B, 2C|comment:"GADD34/TDP-43 and to a lesser extent eIF2A binding was induced by arsenite, PPP1CA was not. Exposure to N-acetylcysteine (NAC), an anti-oxidant, inhibited arsenite-induced GADD34/TDP-43 binding in a dose-dependent manner had no impact on GADD34 binding to either PP1CA or eIF2A."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:8E1C071AE08142CD|rigid:VbHahvogOYQuwLx+056LDFRKpNA false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:P05198 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979030|imex:IM-23248-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N - - - figure legend:Fig. 2A, 2B, 2C|comment:"GADD34/TDP-43 and to a lesser extent eIF2A binding was induced by arsenite, PPP1CA was not. Exposure to N-acetylcysteine (NAC), an anti-oxidant, inhibited arsenite-induced GADD34/TDP-43 binding in a dose-dependent manner had no impact on GADD34 binding to either PP1CA or eIF2A."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606 intact-crc:8E1C071AE08142CD|rigid:VbHahvogOYQuwLx+056LDFRKpNA false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02156 uniprotkb:O75807 intact:EBI-706254|uniprotkb:Q32MQ3|uniprotkb:Q53SL4|uniprotkb:Q53SM5|uniprotkb:Q9UE81|uniprotkb:B0LPH7|ensembl:ENSP00000306124 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 psi-mi:kpce_human(display_long)|uniprotkb:nPKC-epsilon(gene name synonym)|uniprotkb:PRKCE(gene name)|psi-mi:PRKCE(display_short)|uniprotkb:PKCE(gene name synonym) psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979270|imex:IM-23248-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005391.1|refseq:XP_005264485.1|dip:DIP-34186N|ensembl:ENSG00000171132(gene)|ensembl:ENST00000306156(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051301"(cell division)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|mint:Q02156|rcsb pdb:2WH0|rcsb pdb:5LIH|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597 refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 - - - figure legend:Fig. 7B|agonist:"Arsenite (CHEBI:22633)"|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:IYps+mNGHlGam8YJiz/veQbq1s49606 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 intact-crc:C304182B2D45FC4D|rigid:8KFY43ZeXMWWMNgPPjn++pSjnok false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9978992|imex:IM-23248-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - figure legend:Fig. 2A|agonist:"Arsenite (CHEBI:22633)"|comment:"PP1A binding to PPP1R15A (GADD45) is disrupted by the Val556_Phe558Ala mutation."|agonist:Heat shock|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:1A6F1AE52C394C0D|rigid:VKeA23PQ74f6xucgwAhAyNuamlI false mutation:556-556,558-558|sufficient binding region:514-674|flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13148 uniprotkb:O75807 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979119|imex:IM-23248-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 - - - figure legend:Fig. 4B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 intact-crc:FD6CF38E1EFC35A3|rigid:VKeA23PQ74f6xucgwAhAyNuamlI false - flag tag:?-?|sufficient binding region:214-513 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:P62136 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979081|imex:IM-23248-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - figure legend:Fig. 4B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 intact-crc:AD01957DCCC63D65|rigid:vx4cN+yw2K0FEs8ecVerWthTkpg false flag tag:n-n|sufficient binding region:514-674 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979081|imex:IM-23248-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - figure legend:Fig. 4B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/25 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:AD01957DCCC63D65|rigid:vx4cN+yw2K0FEs8ecVerWthTkpg false flag tag:n-n|sufficient binding region:514-674 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13148 uniprotkb:Q01085 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-2820828|uniprotkb:A8K3T0|uniprotkb:A8K4L9|ensembl:ENSP00000394902 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:tiar_human(display_long)|uniprotkb:TIAL1(gene name)|psi-mi:TIAL1(display_short)|uniprotkb:TIA-1-related protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979193|imex:IM-23248-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_001029097.1|refseq:NP_003243.1|ensembl:ENSG00000151923(gene)|ensembl:ENST00000436547(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017145"(stem cell division)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034492|interpro:IPR034494|interpro:IPR034496|interpro:IPR035979|mint:Q01085|rcsb pdb:1X4G|rcsb pdb:2CQI|rcsb pdb:2DH7|reactome:R-HSA-6803529|dip:DIP-42425N - - - figure legend:Fig. 5D|comment:This mutation has no effect in the presence of arsenite. In its absence, TIAR no longer binds.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:dKWzIWmR/JaCJwsOLUPG2Z1uhH89606 intact-crc:2160A989BCDE248D|rigid:sDU0X6+fReAdokI9GuB02ufi/tQ false myc tag:?-?|mutation:173-173,175-175,198-198,244-244 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13148 uniprotkb:O75807 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979193|imex:IM-23248-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 - - - figure legend:Fig. 5D|comment:This mutation has no effect in the presence of arsenite. In its absence, TIAR no longer binds.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 intact-crc:2160A989BCDE248D|rigid:sDU0X6+fReAdokI9GuB02ufi/tQ false myc tag:?-?|mutation:173-173,175-175,198-198,244-244 flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13148 uniprotkb:O75807 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9985191|imex:IM-23248-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 - - - figure legend:Fig. 2B|comment:Cells were treated with Arsenite|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 intact-crc:5E75BAA3A8622021|rigid:sDU0X6+fReAdokI9GuB02ufi/tQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13148 uniprotkb:Q01085 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-2820828|uniprotkb:A8K3T0|uniprotkb:A8K4L9|ensembl:ENSP00000394902 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:tiar_human(display_long)|uniprotkb:TIAL1(gene name)|psi-mi:TIAL1(display_short)|uniprotkb:TIA-1-related protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9985191|imex:IM-23248-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_001029097.1|refseq:NP_003243.1|ensembl:ENSG00000151923(gene)|ensembl:ENST00000436547(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017145"(stem cell division)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034492|interpro:IPR034494|interpro:IPR034496|interpro:IPR035979|mint:Q01085|rcsb pdb:1X4G|rcsb pdb:2CQI|rcsb pdb:2DH7|reactome:R-HSA-6803529|dip:DIP-42425N - - - figure legend:Fig. 2B|comment:Cells were treated with Arsenite|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:dKWzIWmR/JaCJwsOLUPG2Z1uhH89606 intact-crc:5E75BAA3A8622021|rigid:sDU0X6+fReAdokI9GuB02ufi/tQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75807 uniprotkb:Q13148 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9979381|imex:IM-23248-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N - - - figure legend:Supp. Fig. 3A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2014/11/18 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 intact-crc:11F87B226C78C3CC|rigid:VKeA23PQ74f6xucgwAhAyNuamlI false flag tag:n-n green fluorescent protein tag:?-?|mutation with no effect:331-331|mutation with no effect:343-343|mutation with no effect:315-315|mutation with no effect:294-294 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13148 uniprotkb:O75807 intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203 intact:EBI-714746|uniprotkb:Q6IA96|uniprotkb:Q9NVU6|intact:EBI-28977765|ensembl:ENSP00000200453|uniprotkb:B4DKQ3 psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym) psi-mi:pr15a_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD116 homolog(gene name synonym)|uniprotkb:PPP1R15A(gene name)|psi-mi:PPP1R15A(display_short)|uniprotkb:GADD34(gene name synonym)|uniprotkb:Growth arrest and DNA damage-inducible protein GADD34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goh et al. (2017) imex:IM-23248|pubmed:29109149 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-20303339|imex:IM-23248-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N refseq:NP_055145.3|ensembl:ENSG00000087074(gene)|ensembl:ENST00000200453(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016020"(membrane)|ensembl:ENSP00000200453|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032058"(positive regulation of translational initiation in response to stress)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1902310"(positive regulation of peptidyl-serine dephosphorylation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903917"(positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation)|interpro:IPR019523|mint:O75807|rcsb pdb:4XPN|reactome:R-HSA-2173788|reactome:R-HSA-9648895 - - - figure legend:Fig. 5D|comment:This mutation has no effect in the presence of arsenite. In its absence, TIAR no longer binds.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/10/28 2018/05/03 rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606 rogid:2pmlIgM2OX5qK5Bvb1p9x9ZERLw9606 rigid:VKeA23PQ74f6xucgwAhAyNuamlI false myc tag:?-?|mutation:173-173,175-175,198-198,244-244 flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)