#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7Z2H8	uniprotkb:P0CG48	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-3390054|ensembl:ENSP00000344818|ensembl:ENSP00000441543|uniprotkb:Q9BWD6|uniprotkb:P02249|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q9UPK7|uniprotkb:P62988|uniprotkb:P02250|uniprotkb:Q9UEK8|uniprotkb:Q6LDU5|uniprotkb:Q91888|uniprotkb:Q6LBL4|uniprotkb:Q9UEF2|uniprotkb:Q29120|uniprotkb:P02248|uniprotkb:Q9BX98|uniprotkb:Q9UEG1	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:ubc_human(display_long)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5656121|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-9613829|ensembl:ENSG00000150991(gene)|ensembl:ENST00000339647(transcript)|ensembl:ENST00000536769(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG48|rcsb pdb:1C3T|rcsb pdb:1CMX|rcsb pdb:1D3Z|rcsb pdb:1F9J|rcsb pdb:1FXT|rcsb pdb:1G6J|rcsb pdb:1GJZ|rcsb pdb:1NBF|rcsb pdb:1OGW|rcsb pdb:1Q5W|rcsb pdb:1S1Q|rcsb pdb:1SIF|rcsb pdb:1TBE|rcsb pdb:1UBI|rcsb pdb:1UBQ|rcsb pdb:1UD7|rcsb pdb:1XD3|rcsb pdb:1XQQ|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:1ZGU|rcsb pdb:1ZO6|rcsb pdb:2AYO|rcsb pdb:2BGF|rcsb pdb:2DEN|rcsb pdb:2FUH|rcsb pdb:2G45|rcsb pdb:2GBJ|rcsb pdb:2GBK|rcsb pdb:2GBM|rcsb pdb:2GBN|rcsb pdb:2GBR|rcsb pdb:2GMI|rcsb pdb:2HTH|rcsb pdb:2IBI|rcsb pdb:2J7Q|rcsb pdb:2JF5|rcsb pdb:2JRI|interpro:IPR000626(Ubiquitin)|rcsb pdb:2JY6|rcsb pdb:2JZZ|rcsb pdb:2K25|rcsb pdb:2K6D|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:2KDF|rcsb pdb:2KHW|rcsb pdb:2KJH|rcsb pdb:2KLG|rcsb pdb:2KN5|rcsb pdb:2KX0|rcsb pdb:2L3Z|rcsb pdb:2LD9|rcsb pdb:2LVO|rcsb pdb:2LVP|rcsb pdb:2LVQ|rcsb pdb:2LZ6|rcsb pdb:2MBO|rcsb pdb:2MBQ|rcsb pdb:2MCN|rcsb pdb:2MJ5|rcsb pdb:2MOR|rcsb pdb:2MRE|rcsb pdb:2MWS|rcsb pdb:2N2K|rcsb pdb:2NR2|rcsb pdb:2O6V|rcsb pdb:2OJR|rcsb pdb:2PE9|rcsb pdb:2PEA|rcsb pdb:2RR9|rcsb pdb:2RU6|rcsb pdb:2MI8|rcsb pdb:2W9N|rcsb pdb:2WDT|rcsb pdb:2XEW|rcsb pdb:2Y5B|rcsb pdb:2Z59|rcsb pdb:2ZCB|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3A33|rcsb pdb:3ALB|rcsb pdb:3AUL|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:3BY4|rcsb pdb:3C0R|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EEC|rcsb pdb:3EFU|rcsb pdb:3EHV|rcsb pdb:3H7P|rcsb pdb:3H7S|rcsb pdb:3HM3|rcsb pdb:3I3T|rcsb pdb:3IFW|rcsb pdb:3IHP|rcsb pdb:3JSV|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:3LDZ|rcsb pdb:3MHS|rcsb pdb:3MTN|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3N3K|rcsb pdb:3NS8|rcsb pdb:3O65|rcsb pdb:3OFI|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3ONS|rcsb pdb:3PRM|rcsb pdb:3PT2|rcsb pdb:3Q3F|rcsb pdb:3RUL|rcsb pdb:3PTF|rcsb pdb:3TMP|rcsb pdb:3U30|rcsb pdb:3UGB|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:3VFK|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3WXE|rcsb pdb:3WXF|rcsb pdb:3ZLZ|rcsb pdb:3ZNH|rcsb pdb:3ZNI|rcsb pdb:3ZNZ|rcsb pdb:4AP4|rcsb pdb:4AUQ|rcsb pdb:4BOS|rcsb pdb:4BOZ|rcsb pdb:4BVU|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4FJV|rcsb pdb:4HK2|rcsb pdb:4HXD|rcsb pdb:4I6L|rcsb pdb:4I6N|rcsb pdb:4IG7|rcsb pdb:4IUM|rcsb pdb:4JQW|rcsb pdb:4K1R|rcsb pdb:4K7S|rcsb pdb:4K7U|rcsb pdb:4K7W|rcsb pdb:4KSK|rcsb pdb:4KSL|rcsb pdb:4LCD|rcsb pdb:4LDT|rcsb pdb:4MDK|rcsb pdb:4MM3|rcsb pdb:4MSM|rcsb pdb:4MSQ|rcsb pdb:4NQK|rcsb pdb:4UN2|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZP|rcsb pdb:4XOK|rcsb pdb:4XOL|rcsb pdb:4ZQS|rcsb pdb:5A5B|rcsb pdb:5AF4|rcsb pdb:5AF5|rcsb pdb:5AF6|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5B83|rcsb pdb:5C7J|rcsb pdb:5C7M|rcsb pdb:5E6J|rcsb pdb:5H07|rcsb pdb:5NL4|rcsb pdb:5NLF|rcsb pdb:5NLI|rcsb pdb:5NMC|rcsb pdb:5OE7|rcsb pdb:5OHV|rcsb pdb:5OXH|rcsb pdb:5OXI|rcsb pdb:5UDH|rcsb pdb:5WQ4|rcsb pdb:5ZQ3|rcsb pdb:5ZQ4|rcsb pdb:5ZQ5|rcsb pdb:5ZQ6|rcsb pdb:5ZQ7|rcsb pdb:6A43|rcsb pdb:6A44|rcsb pdb:6AQR|rcsb pdb:6B7M|rcsb pdb:6B7O|rcsb pdb:6K2U|rcsb pdb:6KBE|rcsb pdb:6N13|rcsb pdb:6N6R|rcsb pdb:6NQA|rcsb pdb:6NXK|rcsb pdb:6OI4|rcsb pdb:6P5B|rcsb pdb:6Q00|rcsb pdb:6QML|rcsb pdb:6RYA|rcsb pdb:6S53|rcsb pdb:6SQR|rcsb pdb:6T7F|rcsb pdb:6T9L|rcsb pdb:6TNF|rcsb pdb:6TTU|rcsb pdb:6TUV|rcsb pdb:6TXB|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6EQI|rcsb pdb:6UMS|rcsb pdb:6UPU|rcsb pdb:6V5D|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:6VEN|rcsb pdb:6W9D|rcsb pdb:6W9R|rcsb pdb:6W9S|rcsb pdb:6WJD|rcsb pdb:6WKR|rcsb pdb:6WTG|rcsb pdb:6Z7V|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|rcsb pdb:7K6P|rcsb pdb:7K6Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|refseq:NP_066289.3	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:BM+LHQXjMaUn8RZfq1h9jsAAqcs9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:P48047	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:P18859	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:P0CG47	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:Q5VTU8	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-9978245	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:at5el_human(display_long)|uniprotkb:ATP5F1EP2(gene name)|psi-mi:ATP5F1EP2(display_short)|uniprotkb:ATP synthase F1 subunit epsilon pseudogene 2(gene name synonym)|uniprotkb:ATP5EP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:BxEtvJhc/ORkgL561dgMXUUhybs9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:P56381	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-3904845|uniprotkb:E1P5H6|uniprotkb:B2RDD0|uniprotkb:Q53XU6|ensembl:ENSP00000243997|ensembl:ENSP00000379019|ensembl:ENSP00000379023	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:atp5e_human(display_long)|uniprotkb:ATP5F1E(gene name)|psi-mi:ATP5F1E(display_short)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATP5E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	refseq:NP_008817.1|ensembl:ENSG00000124172(gene)|ensembl:ENST00000243997(transcript)|ensembl:ENST00000395659(transcript)|ensembl:ENST00000395663(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:b8qOktspV0v7Gs9uQPpLHf6kLqI9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7Z2H8	uniprotkb:O75947	intact:EBI-9978258|uniprotkb:C9JI34|uniprotkb:Q1LZ56|uniprotkb:Q7Z7C0|uniprotkb:Q86YK4|uniprotkb:Q96M74|ensembl:ENSP00000243389|ensembl:ENSP00000428140	intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6	psi-mi:s36a1_human(display_long)|uniprotkb:SLC36A1(gene name)|psi-mi:SLC36A1(display_short)|uniprotkb:PAT1(gene name synonym)|uniprotkb:Solute carrier family 36 member 1(gene name synonym)	psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978244|imex:IM-23283-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_510968.2|refseq:XP_005268443.1|ensembl:ENSG00000123643|ensembl:ENSG00000123643|refseq:XP_016864705.1|refseq:XP_016864709.1|refseq:NP_001295079.1|refseq:NP_001295080.1|refseq:XP_011535883.1|refseq:XP_011535885.1|refseq:XP_011535886.1|refseq:XP_011535887.1|refseq:XP_011535888.1|refseq:XP_011535889.1|refseq:XP_011535890.1|refseq:XP_011535891.1|refseq:XP_011535892.1|refseq:XP_011535893.1|refseq:XP_011535894.1|ensembl:ENSG00000123643(gene)|ensembl:ENST00000243389(transcript)|ensembl:ENST00000520701(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005368"(taurine transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015180"(L-alanine transmembrane transporter activity)|go:"GO:0015187"(glycine transmembrane transporter activity)|go:"GO:0015193"(L-proline transmembrane transporter activity)|go:"GO:0015734"(taurine transport)|go:"GO:0015808"(L-alanine transport)|go:"GO:0015816"(glycine transport)|go:"GO:0015824"(proline transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022858"(alanine transmembrane transporter activity)|go:"GO:0032328"(alanine transport)|go:"GO:0035524"(proline transmembrane transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-352230|reactome:R-HSA-428559	refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:3ztE6itGzEJNsqsVHHQnjKrDUlI9606	rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606	intact-crc:A96387A3B553AA38|rigid:aYERqOGBfr0Q8iRI1tYaBgtki88	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q9NQL2	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q5VZM2	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q9P035	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q9UHA4	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q9Y2Q5	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:O43504	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q9HB90	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:O15260	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:P45880	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:P48047	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q0VGL1	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:O75947	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978315|imex:IM-23283-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606	intact-crc:3E39FE98005BF79F|rigid:kFKhZk8d0OVwb2LKIT8oZIyQsBc	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q96QD8	uniprotkb:O75947	intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689	intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6	psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short)	psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978368|imex:IM-23283-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1	refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606	rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606	intact-crc:B7349B00F5B97683|rigid:lniHG+HbUWsaas9MdavzNA3fOEw	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q96QD8	uniprotkb:P18859	intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689	intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83	psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short)	psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978368|imex:IM-23283-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1	refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1	intact:EBI-9975668	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606	rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606	intact-crc:B7349B00F5B97683|rigid:lniHG+HbUWsaas9MdavzNA3fOEw	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q96QD8	uniprotkb:Q5VTU8	intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689	intact:EBI-9978245	psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short)	psi-mi:at5el_human(display_long)|uniprotkb:ATP5F1EP2(gene name)|psi-mi:ATP5F1EP2(display_short)|uniprotkb:ATP synthase F1 subunit epsilon pseudogene 2(gene name synonym)|uniprotkb:ATP5EP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978368|imex:IM-23283-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1	interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)	intact:EBI-9975668	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606	rogid:BxEtvJhc/ORkgL561dgMXUUhybs9606	intact-crc:B7349B00F5B97683|rigid:lniHG+HbUWsaas9MdavzNA3fOEw	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q96QD8	uniprotkb:P56381	intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689	intact:EBI-3904845|uniprotkb:E1P5H6|uniprotkb:B2RDD0|uniprotkb:Q53XU6|ensembl:ENSP00000243997|ensembl:ENSP00000379019|ensembl:ENSP00000379023	psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short)	psi-mi:atp5e_human(display_long)|uniprotkb:ATP5F1E(gene name)|psi-mi:ATP5F1E(display_short)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATP5E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978368|imex:IM-23283-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1	refseq:NP_008817.1|ensembl:ENSG00000124172(gene)|ensembl:ENST00000243997(transcript)|ensembl:ENST00000395659(transcript)|ensembl:ENST00000395663(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606	rogid:b8qOktspV0v7Gs9uQPpLHf6kLqI9606	intact-crc:B7349B00F5B97683|rigid:lniHG+HbUWsaas9MdavzNA3fOEw	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q96QD8	uniprotkb:P48047	intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978368|imex:IM-23283-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668	-	-	figure legend:Extended data Fig 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:B7349B00F5B97683|rigid:lniHG+HbUWsaas9MdavzNA3fOEw	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q8IXI1	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1396563|uniprotkb:Q8NF53|uniprotkb:Q96C13|uniprotkb:Q96S17|uniprotkb:Q9BT60|uniprotkb:Q9H7M8|uniprotkb:A2IDC2|ensembl:ENSP00000321971	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:miro2_human(display_long)|uniprotkb:RHOT2(gene name)|psi-mi:RHOT2(display_short)|uniprotkb:ARHT2(gene name synonym)|uniprotkb:C16orf39(gene name synonym)|uniprotkb:Ras homolog gene family member T2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_620124.1|ensembl:ENSG00000140983(gene)|ensembl:ENST00000315082(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|mint:Q8IXI1|rcsb pdb:5KUT|reactome:R-HSA-9013419	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:E+WoN8aoND+U/YkLBUTecrNbDXg9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P00846	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1389380|uniprotkb:Q34772|uniprotkb:Q5S8W5|uniprotkb:Q5S9E7|uniprotkb:Q5S9I6|uniprotkb:Q5SA31|uniprotkb:Q6RPB7|uniprotkb:Q6VHC0|uniprotkb:Q6VHE0|uniprotkb:Q6WQF4|uniprotkb:Q7YCC1|uniprotkb:Q7YCF8|uniprotkb:Q7YCG1|uniprotkb:Q85KU8|uniprotkb:Q85KX1|uniprotkb:Q85L05|uniprotkb:Q8HNQ4|uniprotkb:Q8HNQ8|uniprotkb:Q8WCX6|uniprotkb:Q9B2U5|uniprotkb:Q9B2Z2|ensembl:ENSP00000354632	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp6_human(display_long)|uniprotkb:MT-ATP6(gene name)|psi-mi:MT-ATP6(display_short)|uniprotkb:ATP6(gene name synonym)|uniprotkb:ATPASE6(gene name synonym)|uniprotkb:MTATP6(gene name synonym)|uniprotkb:F-ATPase protein 6(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:YP_003024031.1|go:"GO:0045263"("proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0055093"(response to hyperoxia)|interpro:IPR000568(ATPase, F0 complex, subunit A)|interpro:IPR023011|interpro:IPR035908|mint:P00846|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000198899(gene)|ensembl:ENST00000361899(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0007568"(aging)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:XGt0uP3ldTsWyNSOEiT5kDR5kOw9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P00403	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2105756|uniprotkb:Q37526|ensembl:ENSP00000354876	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:cox2_human(display_long)|uniprotkb:MT-CO2(gene name)|psi-mi:MT-CO2(display_short)|uniprotkb:COII(gene name synonym)|uniprotkb:COXII(gene name synonym)|uniprotkb:MTCO2(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide II(gene name synonym)|uniprotkb:COX2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:YP_003024029.1|ensembl:ENSG00000198712(gene)|ensembl:ENST00000361739(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007595"(lactation)|go:"GO:0009409"(response to cold)|go:"GO:0010729"(positive regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001505("Copper centre Cu(A)")|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR008972(Cupredoxin)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR014222(Cytochrome c oxidase, subunit II)|interpro:IPR034210|interpro:IPR036257|mint:P00403|rcsb pdb:3VRJ|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:NyMmciQe53E935KEZahz8cGPjIM9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P56381	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-3904845|uniprotkb:E1P5H6|uniprotkb:B2RDD0|uniprotkb:Q53XU6|ensembl:ENSP00000243997|ensembl:ENSP00000379019|ensembl:ENSP00000379023	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp5e_human(display_long)|uniprotkb:ATP5F1E(gene name)|psi-mi:ATP5F1E(display_short)|uniprotkb:ATP synthase F1 subunit epsilon(gene name synonym)|uniprotkb:ATP5E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_008817.1|ensembl:ENSG00000124172(gene)|ensembl:ENST00000243997(transcript)|ensembl:ENST00000395659(transcript)|ensembl:ENST00000395663(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:b8qOktspV0v7Gs9uQPpLHf6kLqI9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P10321	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O95674	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-3913685|uniprotkb:Q5TDY5|uniprotkb:Q5TDY3|uniprotkb:Q5TDY2|uniprotkb:Q9NTT2|uniprotkb:Q9BYK5|uniprotkb:Q5TDY4|uniprotkb:D3DW04|uniprotkb:B2RDC6|ensembl:ENSP00000419879	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:cds2_human(display_long)|uniprotkb:CDS2(gene name)|psi-mi:CDS2(display_short)|uniprotkb:CDP-DAG synthase 2(gene name synonym)|uniprotkb:CDP-DG synthase 2(gene name synonym)|uniprotkb:CDP-diacylglycerol synthase 2(gene name synonym)|uniprotkb:CDP-diglyceride pyrophosphorylase 2(gene name synonym)|uniprotkb:CDP-diglyceride synthase 2(gene name synonym)|uniprotkb:"CTP:phosphatidate cytidylyltransferase 2"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_003809.1|ensembl:ENSG00000101290(gene)|ensembl:ENST00000460006(transcript)|go:"GO:0004605"(phosphatidate cytidylyltransferase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006655"(phosphatidylglycerol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016024"(CDP-diacylglycerol biosynthetic process)|go:"GO:0140042"(lipid droplet formation)|interpro:IPR000374(Phosphatidate cytidylyltransferase)|interpro:IPR016720(Phosphatidate cytidylyltransferase, eukaryota)|mint:O95674|reactome:R-HSA-1483148	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:tCRLIDMiesBx7QPKIycdX3Igz589606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9BSD7	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2689235|ensembl:ENSP00000355587	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:ntpcr_human(display_long)|uniprotkb:Nucleoside triphosphate phosphohydrolase(gene name synonym)|uniprotkb:NTPCR(gene name)|psi-mi:NTPCR(display_short)|uniprotkb:C1orf57(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_115700.1|interpro:IPR027417|mint:Q9BSD7|rcsb pdb:2I3B|ensembl:ENSG00000135778(gene)|ensembl:ENST00000366628(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004948(Protein of unknown function DUF265)|refseq:NP_001316382.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:tJoP+XQzoa4urq6g1rdZhMWO49g9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q15392	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q8WWC4	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1042937|ensembl:ENSP00000295079|ensembl:ENSP00000376111|uniprotkb:Q658V9|uniprotkb:Q9H671	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:maip1_human(display_long)|uniprotkb:MAIP1(gene name)|psi-mi:MAIP1(display_short)|uniprotkb:C2orf47(gene name synonym)|uniprotkb:Matrix AAA peptidase-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000162972(gene)|ensembl:ENST00000295079(transcript)|ensembl:ENST00000392290(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0032979"(protein insertion into mitochondrial inner membrane from matrix)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043022"(ribosome binding)|go:"GO:0051204"(protein insertion into mitochondrial membrane)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|mint:Q8WWC4|reactome:R-HSA-8949664|refseq:NP_078796.2	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:kQCnnlC1WF95Jb2djLyrYldRikg9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9NRP0	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1044658|uniprotkb:B2R5H1|ensembl:ENSP00000354676|uniprotkb:A8MYS2|uniprotkb:Q9P075|uniprotkb:Q9P1R4|uniprotkb:D6RH22	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:ostc_human(display_long)|uniprotkb:DC2(orf name)|uniprotkb:HDCMD45P(orf name)|uniprotkb:HSPC307(orf name)|uniprotkb:Hydrophobic protein HSF-28(gene name synonym)|uniprotkb:OSTC(gene name)|psi-mi:OSTC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_067050.1|ensembl:ENSG00000198856(gene)|ensembl:ENST00000361564(transcript)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|interpro:IPR021149|interpro:IPR042416|mint:Q9NRP0|rcsb pdb:6S7O|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|refseq:NP_001254746.1|refseq:NP_001254747.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:7hCT4erjmVblwj7wzSb2af+yLu09606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q5VTU8	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-9978245	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:at5el_human(display_long)|uniprotkb:ATP5F1EP2(gene name)|psi-mi:ATP5F1EP2(display_short)|uniprotkb:ATP synthase F1 subunit epsilon pseudogene 2(gene name synonym)|uniprotkb:ATP5EP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	interpro:IPR006721(ATPase, F1 complex, epsilon subunit, mitochondrial)|interpro:IPR036742|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:BxEtvJhc/ORkgL561dgMXUUhybs9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O75964	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1044001|uniprotkb:Q96BV6|uniprotkb:Q9UBZ7|ensembl:ENSP00000300688|uniprotkb:A8K0K3	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp5l_human(display_long)|uniprotkb:ATP5MG(gene name)|psi-mi:ATP5MG(display_short)|uniprotkb:ATP synthase membrane subunit g(gene name synonym)|uniprotkb:ATP5L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_006467.4|ensembl:ENSG00000167283(gene)|ensembl:ENST00000300688(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR006808(ATPase, F0 complex, subunit G, mitochondrial)|interpro:IPR016702(Mitochondrial ATP synthase subunit g, animal)|mint:O75964|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:mn5/fFqk4xCCHb/MEuLAi5/lqmI9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P56385	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2270000|uniprotkb:Q0D2L9|ensembl:ENSP00000306003	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp5i_human(display_long)|uniprotkb:ATP5ME(gene name)|psi-mi:ATP5ME(display_short)|uniprotkb:ATP5I(gene name synonym)|uniprotkb:ATP synthase membrane subunit e(gene name synonym)|uniprotkb:ATP5K(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_009031.1|ensembl:ENSG00000169020(gene)|ensembl:ENST00000304312(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR008386(ATPase, F0 complex, subunit E, mitochondrial)|mint:P56385|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:NYpqzWQYASXwSwU/BYDTMU2tJjI9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P18859	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q99653	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O95490	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2865302|uniprotkb:Q9UKY5|uniprotkb:B1ALT9|uniprotkb:B1ALU0|uniprotkb:Q9UKY6|uniprotkb:B1ALT8|uniprotkb:O94882|uniprotkb:Q5VX76|uniprotkb:A5XEI2|uniprotkb:B1ALU2|uniprotkb:B1ALU4|uniprotkb:B1ALU5|uniprotkb:B1ALU6|intact:EBI-28986872|ensembl:ENSP00000359752|ensembl:ENSP00000359763	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:agrl2_human(display_long)|uniprotkb:ADGRL2(gene name)|psi-mi:ADGRL2(display_short)|uniprotkb:Calcium-independent alpha-latrotoxin receptor 2(gene name synonym)|uniprotkb:KIAA0786(gene name synonym)|uniprotkb:LEC1(gene name synonym)|uniprotkb:LPHH1(gene name synonym)|uniprotkb:LPHN2(gene name synonym)|uniprotkb:Latrophilin homolog 1(gene name synonym)|uniprotkb:Latrophilin-2(gene name synonym)|uniprotkb:Lectomedin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001284633.1|refseq:NP_001284634.1|refseq:NP_001284635.1|refseq:NP_036434.1|ensembl:ENST00000319517|ensembl:ENSP00000322270|ensembl:ENST00000359929|ensembl:ENSP00000353006|ensembl:ENST00000370713|ensembl:ENSP00000359748|ensembl:ENST00000370715|ensembl:ENSP00000359750|ensembl:ENSP00000359752|ensembl:ENST00000370723|ensembl:ENSP00000359758|ensembl:ENST00000370725|ensembl:ENSP00000359760|ensembl:ENSP00000359763|ensembl:ENST00000370730|ensembl:ENSP00000359765|ensembl:ENST00000674393|ensembl:ENSP00000501431|ensembl:ENST00000674419|ensembl:ENSP00000501462|refseq:XP_005270723.1|refseq:NP_001317574.1|refseq:XP_016856276.1|ensembl:ENSG00000117114(gene)|ensembl:ENST00000370717(transcript)|ensembl:ENST00000370728(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009617"(response to bacterium)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016524"(latrotoxin receptor activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043005"(neuron projection)|go:"GO:0050808"(synapse organization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000922(D-galactoside/L-rhamnose binding SUEL lectin)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003112(Olfactomedin-like)|interpro:IPR003334(GPCR, family 2, latrophilin, C-terminal)|interpro:IPR003924(GPCR, family 2, latrophilin)|interpro:IPR017981|interpro:IPR017983|interpro:IPR031240|interpro:IPR032471|interpro:IPR036445|interpro:IPR043159	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:WkTs1zEQmAT82KxUL2+V7KG74UQ9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q15043	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-6116466|uniprotkb:A6NH98|uniprotkb:B4DIW3|uniprotkb:B6EU88|uniprotkb:D3DSR4|uniprotkb:Q6ZME8|uniprotkb:Q96BB3|ensembl:ENSP00000289952|ensembl:ENSP00000370635	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:s39ae_human(display_long)|uniprotkb:SLC39A14(gene name)|psi-mi:SLC39A14(display_short)|uniprotkb:KIAA0062(gene name synonym)|uniprotkb:ZIP14(gene name synonym)|uniprotkb:LIV-1 subfamily of ZIP zinc transporter 4(gene name synonym)|uniprotkb:Solute carrier family 39 member 14(gene name synonym)|uniprotkb:Zrt- and Irt-like protein 14(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:XP_011542780.1|refseq:NP_001121903.1|refseq:NP_001128625.1|refseq:NP_056174.2|refseq:XP_005273522.1|refseq:XP_005273523.1|refseq:XP_006716387.1|refseq:XP_016868783.1|refseq:XP_016868784.1|ensembl:ENSG00000104635(gene)|ensembl:ENST00000289952(transcript)|ensembl:ENST00000381237(transcript)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010817"(regulation of hormone levels)|go:"GO:0015086"(cadmium ion transmembrane transporter activity)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0015296"("anion:cation symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033212"(iron import into cell)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055071"(manganese ion homeostasis)|go:"GO:0070574"(cadmium ion transmembrane transport)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071578"(zinc ion import across plasma membrane)|go:"GO:0098739"(import across plasma membrane)|interpro:IPR003689(Zinc/iron permease)|mint:Q15043|reactome:R-HSA-442380	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:tpJl2FORU2if7SOPN8ZDwPvF+HM9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9HC07	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-3920600|uniprotkb:B4DHW1|ensembl:ENSP00000370736|uniprotkb:Q9BTN9|uniprotkb:A8K3P8|uniprotkb:Q9NZ34	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:tm165_human(display_long)|uniprotkb:TMEM165(gene name)|psi-mi:TMEM165(display_short)|uniprotkb:TPARL(gene name synonym)|uniprotkb:Transmembrane protein PT27(gene name synonym)|uniprotkb:Transmembrane protein TPARL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000134851(gene)|ensembl:ENST00000381334(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032468"(Golgi calcium ion homeostasis)|go:"GO:0032472"(Golgi calcium ion transport)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071421"(manganese ion transmembrane transport)|interpro:IPR001727(Protein of unknown function UPF0016)|mint:Q9HC07|refseq:NP_060945.2|refseq:XP_016863901.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:ldHk1rPCEZrMLw8Pj6zVshPaNw09606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9Y679	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1058701|ensembl:ENSP00000366748|uniprotkb:Q9H866|uniprotkb:Q9UNQ6|uniprotkb:Q9Y685|uniprotkb:C0H5W8	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:aup1_human(display_long)|uniprotkb:AUP1(gene name)|psi-mi:AUP1(display_short)|uniprotkb:Ancient ubiquitous protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000115307(gene)|ensembl:ENST00000377526(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_853553.1|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:0140042"(lipid droplet formation)|go:"GO:1990044"(protein localization to lipid droplet)|interpro:IPR003892(Ubiquitin system component Cue)|rcsb pdb:2EKF	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:6yySfIPpRUlnm0upBDYyfBUOtIY9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O43592	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q5HYI8	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2824032|uniprotkb:Q8WUD3|ensembl:ENSP00000273375	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:rabl3_human(display_long)|uniprotkb:RABL3(gene name)|psi-mi:RABL3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000144840(gene)|ensembl:ENST00000273375(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:1903059"(regulation of protein lipidation)|interpro:IPR027417|mint:Q5HYI8|go:"GO:0050821"(protein stabilization)|refseq:NP_776186.2	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:wa/T6PILk7wiphCKdnT3OidKB0E9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q96IX5	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-954033|ensembl:ENSP00000311245|ensembl:ENSP00000337705|ensembl:ENSP00000358826|ensembl:ENSP00000358830|ensembl:ENSP00000358840|uniprotkb:B2R4N2|uniprotkb:D3DR92	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atpmk_human(display_long)|uniprotkb:ATP5MK(gene name)|psi-mi:ATP5MK(display_short)|uniprotkb:ATP synthase membrane subunit DAPIT, mitochondrial(gene name synonym)|uniprotkb:ATP5MD(gene name synonym)|uniprotkb:DAPIT(gene name synonym)|uniprotkb:Diabetes-associated protein in insulin-sensitive tissues(gene name synonym)|uniprotkb:HCV F-transactivated protein 2(gene name synonym)|uniprotkb:HCVFTP2(gene name synonym)|uniprotkb:USMG5(gene name synonym)|uniprotkb:Up-regulated during skeletal muscle growth protein 5(gene name synonym)|uniprotkb:PD04912(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000173915(gene)|ensembl:ENST00000309579(transcript)|ensembl:ENST00000337003(transcript)|ensembl:ENST00000369811(transcript)|ensembl:ENST00000369815(transcript)|ensembl:ENST00000369825(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009125(DAPIT)|mint:Q96IX5|refseq:NP_001193355.1|refseq:NP_001193356.1|refseq:NP_116136.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:7ClNWlgeH39kD7E6oiQdkuj7Hag9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O95197	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P20020	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:kCpUNLYDF38hciXj32D8rXbXULg9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P45880	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P0CG47	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P61619	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q53GQ0	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9Y4W6	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q92543	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-728232|ensembl:ENSP00000265909|uniprotkb:E9PKB9|uniprotkb:Q8IV55	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:snx19_human(display_long)|uniprotkb:SNX19(gene name)|psi-mi:SNX19(display_short)|uniprotkb:KIAA0254(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000120451(gene)|ensembl:ENST00000265909(transcript)|refseq:NP_055573.2|refseq:NP_001334847.1|refseq:NP_001334848.1|refseq:NP_001334849.1|refseq:NP_001334850.1|refseq:NP_001334851.1|refseq:NP_001334852.1|refseq:NP_001334853.1|refseq:NP_001334854.1|refseq:NP_001334855.1|refseq:NP_001334856.1|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0006887"(exocytosis)|go:"GO:0030073"(insulin secretion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR001683(Phox-like)|interpro:IPR003114(PX-associated)|interpro:IPR013937(Sorting nexin, C-terminal)|interpro:IPR034908|interpro:IPR036871|interpro:IPR037909	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:K3NS39vRx+FYSZXGpylwf32l0ug9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9H936	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1050588|uniprotkb:Q8TBU8|uniprotkb:A8K366|uniprotkb:C9J1H6|uniprotkb:E9PJD3|uniprotkb:E9PKB2|uniprotkb:E9PL68|uniprotkb:E9PN26|uniprotkb:E9PNQ3|uniprotkb:E9PP01|uniprotkb:E9PR97|ensembl:ENSP00000322020|ensembl:ENSP00000437236|ensembl:ENSP00000486058	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:ghc1_human(display_long)|uniprotkb:"Glutamate/H(+) symporter 1"(gene name synonym)|uniprotkb:Solute carrier family 25 member 22(gene name synonym)|uniprotkb:SLC25A22(gene name)|psi-mi:SLC25A22(display_short)|uniprotkb:GC1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001177989.1|refseq:NP_001177990.1|refseq:NP_078974.1|ensembl:ENSG00000177542(gene)|ensembl:ENST00000320230(transcript)|ensembl:ENST00000531214(transcript)|ensembl:ENST00000628067(transcript)|go:"GO:0005280"("amino acid:proton symporter activity")|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006811"(ion transport)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0043490"(malate-aspartate shuttle)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR018108|interpro:IPR023395|reactome:R-HSA-428643|refseq:XP_011518671.1|refseq:XP_011518672.1|refseq:XP_011518673.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:B1e6uu3Vx73qy/JrHS7p63p0QMM9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q71U36	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9P035	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q96AA3	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-6269616|ensembl:ENSP00000296292|uniprotkb:Q96J03	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:rft1_human(display_long)|uniprotkb:RFT1(gene name)|psi-mi:RFT1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000163933(gene)|ensembl:ENST00000296292(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006488"(dolichol-linked oligosaccharide biosynthetic process)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034202"(glycolipid floppase activity)|go:"GO:0034203"(glycolipid translocation)|interpro:IPR007594(RFT1)|mint:Q96AA3|reactome:R-HSA-446193|reactome:R-HSA-4570571|refseq:NP_443091.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:off+uN6MYDiLT5q1oh7G2sd6RXw9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P48047	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P24539	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:n1HuorsLzONcID7ccOL9qEsODLE9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O75947	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q01650	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-6138761|uniprotkb:Q8IV97|uniprotkb:Q9UBN8|uniprotkb:Q9UP15|uniprotkb:Q9UQC0|ensembl:ENSP00000261622	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:lat1_human(display_long)|uniprotkb:SLC7A5(gene name)|psi-mi:SLC7A5(display_short)|uniprotkb:CD98LC(gene name synonym)|uniprotkb:LAT1(gene name synonym)|uniprotkb:MPE16(gene name synonym)|uniprotkb:4F2 light chain(gene name synonym)|uniprotkb:CD98 light chain(gene name synonym)|uniprotkb:Integral membrane protein E16(gene name synonym)|uniprotkb:L-type amino acid transporter 1(gene name synonym)|uniprotkb:Solute carrier family 7 member 5(gene name synonym)|uniprotkb:y+ system cationic amino acid transporter(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_003477.4|ensembl:ENSG00000103257(gene)|ensembl:ENST00000261622(transcript)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015173"(aromatic amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0015196"(L-tryptophan transmembrane transporter activity)|go:"GO:0015349"(thyroid hormone transmembrane transporter activity)|go:"GO:0015823"(phenylalanine transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070327"(thyroid hormone transport)|go:"GO:0089718"(amino acid import across plasma membrane)|go:"GO:0098591"(external side of apical plasma membrane)|go:"GO:0098713"(leucine import across plasma membrane)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903801"(L-leucine import across plasma membrane)|go:"GO:1904556"(L-tryptophan transmembrane transport)|go:"GO:1990184"(amino acid transport complex)|interpro:IPR002293(Amino acid/polyamine transporter I)|interpro:IPR004760(L-type amino acid transporter)|mint:Q01650|rcsb pdb:6IRS|rcsb pdb:6IRT|rcsb pdb:6JMQ|rcsb pdb:7DSK|rcsb pdb:7DSL|rcsb pdb:7DSN|rcsb pdb:7DSQ|reactome:R-HSA-210991|reactome:R-HSA-352230|reactome:R-HSA-71240|go:"GO:0015804"(neutral amino acid transport)	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:GrXTCUhrHMNCnvscgx1ink2opoU9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P0CG48	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-3390054|ensembl:ENSP00000344818|ensembl:ENSP00000441543|uniprotkb:Q9BWD6|uniprotkb:P02249|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q9UPK7|uniprotkb:P62988|uniprotkb:P02250|uniprotkb:Q9UEK8|uniprotkb:Q6LDU5|uniprotkb:Q91888|uniprotkb:Q6LBL4|uniprotkb:Q9UEF2|uniprotkb:Q29120|uniprotkb:P02248|uniprotkb:Q9BX98|uniprotkb:Q9UEG1	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:ubc_human(display_long)|uniprotkb:UBC(gene name)|psi-mi:UBC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5656121|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-9613829|ensembl:ENSG00000150991(gene)|ensembl:ENST00000339647(transcript)|ensembl:ENST00000536769(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG48|rcsb pdb:1C3T|rcsb pdb:1CMX|rcsb pdb:1D3Z|rcsb pdb:1F9J|rcsb pdb:1FXT|rcsb pdb:1G6J|rcsb pdb:1GJZ|rcsb pdb:1NBF|rcsb pdb:1OGW|rcsb pdb:1Q5W|rcsb pdb:1S1Q|rcsb pdb:1SIF|rcsb pdb:1TBE|rcsb pdb:1UBI|rcsb pdb:1UBQ|rcsb pdb:1UD7|rcsb pdb:1XD3|rcsb pdb:1XQQ|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:1ZGU|rcsb pdb:1ZO6|rcsb pdb:2AYO|rcsb pdb:2BGF|rcsb pdb:2DEN|rcsb pdb:2FUH|rcsb pdb:2G45|rcsb pdb:2GBJ|rcsb pdb:2GBK|rcsb pdb:2GBM|rcsb pdb:2GBN|rcsb pdb:2GBR|rcsb pdb:2GMI|rcsb pdb:2HTH|rcsb pdb:2IBI|rcsb pdb:2J7Q|rcsb pdb:2JF5|rcsb pdb:2JRI|interpro:IPR000626(Ubiquitin)|rcsb pdb:2JY6|rcsb pdb:2JZZ|rcsb pdb:2K25|rcsb pdb:2K6D|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:2KDF|rcsb pdb:2KHW|rcsb pdb:2KJH|rcsb pdb:2KLG|rcsb pdb:2KN5|rcsb pdb:2KX0|rcsb pdb:2L3Z|rcsb pdb:2LD9|rcsb pdb:2LVO|rcsb pdb:2LVP|rcsb pdb:2LVQ|rcsb pdb:2LZ6|rcsb pdb:2MBO|rcsb pdb:2MBQ|rcsb pdb:2MCN|rcsb pdb:2MJ5|rcsb pdb:2MOR|rcsb pdb:2MRE|rcsb pdb:2MWS|rcsb pdb:2N2K|rcsb pdb:2NR2|rcsb pdb:2O6V|rcsb pdb:2OJR|rcsb pdb:2PE9|rcsb pdb:2PEA|rcsb pdb:2RR9|rcsb pdb:2RU6|rcsb pdb:2MI8|rcsb pdb:2W9N|rcsb pdb:2WDT|rcsb pdb:2XEW|rcsb pdb:2Y5B|rcsb pdb:2Z59|rcsb pdb:2ZCB|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3A33|rcsb pdb:3ALB|rcsb pdb:3AUL|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:3BY4|rcsb pdb:3C0R|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EEC|rcsb pdb:3EFU|rcsb pdb:3EHV|rcsb pdb:3H7P|rcsb pdb:3H7S|rcsb pdb:3HM3|rcsb pdb:3I3T|rcsb pdb:3IFW|rcsb pdb:3IHP|rcsb pdb:3JSV|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:3LDZ|rcsb pdb:3MHS|rcsb pdb:3MTN|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3N3K|rcsb pdb:3NS8|rcsb pdb:3O65|rcsb pdb:3OFI|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3ONS|rcsb pdb:3PRM|rcsb pdb:3PT2|rcsb pdb:3Q3F|rcsb pdb:3RUL|rcsb pdb:3PTF|rcsb pdb:3TMP|rcsb pdb:3U30|rcsb pdb:3UGB|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:3VFK|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3WXE|rcsb pdb:3WXF|rcsb pdb:3ZLZ|rcsb pdb:3ZNH|rcsb pdb:3ZNI|rcsb pdb:3ZNZ|rcsb pdb:4AP4|rcsb pdb:4AUQ|rcsb pdb:4BOS|rcsb pdb:4BOZ|rcsb pdb:4BVU|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4FJV|rcsb pdb:4HK2|rcsb pdb:4HXD|rcsb pdb:4I6L|rcsb pdb:4I6N|rcsb pdb:4IG7|rcsb pdb:4IUM|rcsb pdb:4JQW|rcsb pdb:4K1R|rcsb pdb:4K7S|rcsb pdb:4K7U|rcsb pdb:4K7W|rcsb pdb:4KSK|rcsb pdb:4KSL|rcsb pdb:4LCD|rcsb pdb:4LDT|rcsb pdb:4MDK|rcsb pdb:4MM3|rcsb pdb:4MSM|rcsb pdb:4MSQ|rcsb pdb:4NQK|rcsb pdb:4UN2|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZP|rcsb pdb:4XOK|rcsb pdb:4XOL|rcsb pdb:4ZQS|rcsb pdb:5A5B|rcsb pdb:5AF4|rcsb pdb:5AF5|rcsb pdb:5AF6|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5B83|rcsb pdb:5C7J|rcsb pdb:5C7M|rcsb pdb:5E6J|rcsb pdb:5H07|rcsb pdb:5NL4|rcsb pdb:5NLF|rcsb pdb:5NLI|rcsb pdb:5NMC|rcsb pdb:5OE7|rcsb pdb:5OHV|rcsb pdb:5OXH|rcsb pdb:5OXI|rcsb pdb:5UDH|rcsb pdb:5WQ4|rcsb pdb:5ZQ3|rcsb pdb:5ZQ4|rcsb pdb:5ZQ5|rcsb pdb:5ZQ6|rcsb pdb:5ZQ7|rcsb pdb:6A43|rcsb pdb:6A44|rcsb pdb:6AQR|rcsb pdb:6B7M|rcsb pdb:6B7O|rcsb pdb:6K2U|rcsb pdb:6KBE|rcsb pdb:6N13|rcsb pdb:6N6R|rcsb pdb:6NQA|rcsb pdb:6NXK|rcsb pdb:6OI4|rcsb pdb:6P5B|rcsb pdb:6Q00|rcsb pdb:6QML|rcsb pdb:6RYA|rcsb pdb:6S53|rcsb pdb:6SQR|rcsb pdb:6T7F|rcsb pdb:6T9L|rcsb pdb:6TNF|rcsb pdb:6TTU|rcsb pdb:6TUV|rcsb pdb:6TXB|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6EQI|rcsb pdb:6UMS|rcsb pdb:6UPU|rcsb pdb:6V5D|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:6VEN|rcsb pdb:6W9D|rcsb pdb:6W9R|rcsb pdb:6W9S|rcsb pdb:6WJD|rcsb pdb:6WKR|rcsb pdb:6WTG|rcsb pdb:6Z7V|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|rcsb pdb:7K6P|rcsb pdb:7K6Q|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|refseq:NP_066289.3	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:BM+LHQXjMaUn8RZfq1h9jsAAqcs9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P01889	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q8WZA1	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-3912424|uniprotkb:Q5VST2|uniprotkb:D3DQ16|uniprotkb:Q9BV55|uniprotkb:Q9H9L8|uniprotkb:Q9NXF9|uniprotkb:Q9NYF7|ensembl:ENSP00000361052|uniprotkb:Q5VST3	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:pmgt1_human(display_long)|uniprotkb:POMGNT1(gene name)|psi-mi:POMGNT1(display_short)|uniprotkb:MGAT1.2(gene name synonym)|uniprotkb:"UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2"(gene name synonym)|uniprotkb:UNQ746/PRO1475(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:XP_006710819.1|refseq:NP_060209.3|ensembl:ENSG00000085998(gene)|ensembl:ENST00000371984(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0047223"(beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity)|interpro:IPR004139(Glycosyl transferase, family 13)|interpro:IPR029044|interpro:IPR039474|interpro:IPR039477|mint:Q8WZA1|rcsb pdb:5GGF|rcsb pdb:5GGG|rcsb pdb:5GGI|rcsb pdb:5GGJ|rcsb pdb:5GGK|rcsb pdb:5GGL|rcsb pdb:5GGN|rcsb pdb:5GGO|rcsb pdb:5GGP|rcsb pdb:5XFC|reactome:R-HSA-5083628|reactome:R-HSA-5173105|refseq:XP_016857179.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:Ohk+ND7B4l9EvsCnHL5w7NQHeIk9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9Y277	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:P30049	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9H853	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-355902|ensembl:ENSP00000487719	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:tba4b_human(display_long)|uniprotkb:TUBA4B(gene name)|psi-mi:TUBA4B(display_short)|uniprotkb:TUBA4(gene name synonym)|uniprotkb:Alpha-tubulin 4B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	ensembl:ENSG00000243910(gene)|ensembl:ENST00000490341(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR036525|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:iBjadHjxXIhrRYnUm5yviGSvRhA9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q6P4A7	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-1049439|uniprotkb:Q6WSU4|uniprotkb:Q86TD9|ensembl:ENSP00000347924	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:sfxn4_human(display_long)|uniprotkb:Breast cancer resistance marker 1(gene name synonym)|uniprotkb:SFXN4(gene name)|psi-mi:SFXN4(display_short)|uniprotkb:BCRM1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_998814.1|refseq:XP_011537584.1|refseq:XP_005269583.1|refseq:XP_005269584.1|ensembl:ENSG00000183605(gene)|ensembl:ENST00000355697(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|interpro:IPR028825	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:D/Ae1Kd5aIiliqNVmS7aFaIpwsk9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:O94905	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-4400770|uniprotkb:A0JLQ1|uniprotkb:A8K5S9|uniprotkb:B4DM38|uniprotkb:D3DSW0|uniprotkb:Q6NW21|uniprotkb:Q86VS6|uniprotkb:Q86W49|ensembl:ENSP00000428112	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:erln2_human(display_long)|uniprotkb:ERLIN2(gene name)|psi-mi:ERLIN2(display_short)|uniprotkb:C8orf2(gene name synonym)|uniprotkb:SPFH2(gene name synonym)|uniprotkb:Endoplasmic reticulum lipid raft-associated protein 2(gene name synonym)|uniprotkb:Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2(gene name synonym)|uniprotkb:UNQ2441/PRO5003/PRO9924(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	refseq:NP_001003790.1|refseq:NP_001003791.1|refseq:NP_009106.1|refseq:XP_016868489.1|refseq:XP_005273449.1|ensembl:ENSG00000147475(gene)|ensembl:ENST00000519638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|interpro:IPR001107(Band 7 protein)|interpro:IPR033294|interpro:IPR036013|mint:O94905|reactome:R-HSA-382556|reactome:R-HSA-5655302|reactome:R-HSA-5678895|reactome:R-HSA-8853336	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:Evjg3G0FFeQ499BNlJxpK6t8to89606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9H2H9	uniprotkb:Q9NY65	intact:EBI-9978441|ensembl:ENSP00000381634|ensembl:ENSP00000398142|ensembl:ENSP00000447853|ensembl:ENSP00000449607|uniprotkb:Q8NC61|uniprotkb:Q8NCF8|uniprotkb:Q96JX2|uniprotkb:Q9H2Q2	intact:EBI-356246|ensembl:ENSP00000333326|uniprotkb:B3KPW9|uniprotkb:Q2M3N4|uniprotkb:B2RCX2|uniprotkb:B4DWG3	psi-mi:s38a1_human(display_long)|uniprotkb:SLC38A1(gene name)|psi-mi:SLC38A1(display_short)|uniprotkb:ATA1(gene name synonym)|uniprotkb:NAT2(gene name synonym)|uniprotkb:SAT1(gene name synonym)|uniprotkb:SNAT1(gene name synonym)|uniprotkb:Amino acid transporter A1(gene name synonym)|uniprotkb:N-system amino acid transporter 2(gene name synonym)|uniprotkb:Solute carrier family 38 member 1(gene name synonym)|uniprotkb:System A amino acid transporter 1(gene name synonym)|uniprotkb:System N amino acid transporter 1(gene name synonym)	psi-mi:tba8_human(display_long)|uniprotkb:TUBA8(gene name)|psi-mi:TUBA8(display_short)|uniprotkb:TUBAL2(gene name synonym)|uniprotkb:Alpha-tubulin 8(gene name synonym)|uniprotkb:Tubulin alpha chain-like 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978490|imex:IM-23283-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111371(gene)|ensembl:ENST00000398637(transcript)|ensembl:ENST00000439706(transcript)|ensembl:ENST00000546893(transcript)|ensembl:ENST00000549049(transcript)|go:"GO:0001504"(neurotransmitter uptake)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005283"("amino acid:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015179"(L-amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0030424"(axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902475"(L-alpha-amino acid transmembrane transport)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210455|reactome:R-HSA-352230|go:"GO:0098591"(external side of apical plasma membrane)|refseq:NP_001070952.1|refseq:NP_001265316.1|refseq:NP_001265317.1|refseq:NP_001265318.1|refseq:NP_109599.3	reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001180343.1|refseq:NP_061816.1|ensembl:ENSG00000183785(gene)|ensembl:ENST00000330423(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|dip:DIP-40751N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Extended data Fig 3D|caution:[EBI-9978392] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-6163567] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-3905378] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-1058803] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|caution:[EBI-4400689] The protein has been merged with EBI-1051396 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2019/10/18	rogid:bywv401DbQBHRZvcPc8o8mp8nfE9606	rogid:OGRoBAwLchNlK3LtAWkbSbCcxPQ9606	intact-crc:01EAFDDEE7325AEE|rigid:oVKaj6dq4gLA62i8j4Xw7mg0Jik	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q9NQL2	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q5VZM2	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q7L523	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q9Y2Q5	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:O43504	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q8N122	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q9HB90	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q8NBW4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q6IAA8	uniprotkb:Q0VGL1	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978657|imex:IM-23283-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:5015C4EA30C25757|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q5VZM2	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q9NQL2	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q9P278	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-7597109|intact:MINT-7298240|uniprotkb:Q05DC3|uniprotkb:Q9H994|uniprotkb:Q96I31|ensembl:ENSP00000264433	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:fnip2_human(display_long)|uniprotkb:O6-methylguanine-induced apoptosis 1 protein(gene name synonym)|uniprotkb:FNIPL(gene name synonym)|uniprotkb:MAPO1(gene name synonym)|uniprotkb:FNIP2(gene name)|psi-mi:FNIP2(display_short)|uniprotkb:KIAA1450(gene name synonym)|uniprotkb:FNIP1-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_001310845.1|refseq:NP_001332972.1|refseq:NP_065891.1|ensembl:ENSG00000052795(gene)|ensembl:ENST00000264433(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0051087"(chaperone binding)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q9P278|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	comment:mint	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:hdSPB5yh7jtlmQogUtH8Lkjhs5k9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q0VGL1	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q6IAA8	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q7L523	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:P61421	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-954063|ensembl:ENSP00000290949|uniprotkb:P12953|uniprotkb:Q02547	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:va0d1_human(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:32 kDa accessory protein(gene name synonym)|uniprotkb:ATP6V0D1(gene name)|psi-mi:ATP6V0D1(display_short)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VPATPD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	ensembl:ENSG00000159720(gene)|ensembl:ENST00000290949(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P61421|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-381038|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016324"(apical plasma membrane)|refseq:NP_004682.2|dip:DIP-47435N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:3a/yIxEF9LMwAZUR3npGQrw8xNo9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q9HB90	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q9Y2Q5	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q8NFG4	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q8NBW4	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:O43504	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UHA4	uniprotkb:Q8N122	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978673|imex:IM-23283-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:C7B9DC741BD935B6|rigid:aqnc/wscZEjSCH0I5KXpK9GdgSk	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q9NQL2	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q5VZM2	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q8NBW4	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q9UHA4	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q9Y2Q5	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:O43504	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q9HB90	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q7L523	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q8N122	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q0VGL1	uniprotkb:Q6IAA8	intact:EBI-5658976|ensembl:ENSP00000343118	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978692|imex:IM-23283-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:44E67B5B30FDEE22|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	ha tag:c-c|strep ii tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q9NQL2	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q5VZM2	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q6IAA8	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q9Y2Q5	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q9HB90	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q9UHA4	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q0VGL1	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q8NBW4	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q7L523	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O43504	uniprotkb:Q8N122	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978707|imex:IM-23283-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:D672B4B401B15216|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:c-c|ha tag:c-c	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q5VZM2	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q9NQL2	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q8N122	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q8NBW4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q9Y2Q5	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q9HB90	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q6IAA8	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:O43504	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q0VGL1	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q7L523	uniprotkb:Q9UHA4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978724|imex:IM-23283-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:843F1F5DA5B7D41F|rigid:YRcY+Qcrm95elBQrEfbnfozPY1Y	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q5VZM2	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q9Y2Q5	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q8N122	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q0VGL1	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q8NBW4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9HB90	uniprotkb:O43504	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9978741|imex:IM-23283-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	intact:EBI-9975664(intact-secondary)	-	-	figure legend:Fig. 2a, Extended Data Fig. 5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:F8BF8CC0A1D0CC5A|rigid:KZHb6PczirG8gr1LKhJ3wDlvFO8	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060857|imex:IM-23283-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:DDF8506237642C35|rigid:fEe9nq4i6LblQijUKKvW3tcW1+w	false	ha tag:n-n|strep ii tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7L523	uniprotkb:Q6IAA8	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060899|imex:IM-23283-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1D|comment:Interaction observed when SLC38A9 was silenced.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:D0BC33018B179273|rigid:ENCg1r/P0BhDL1dGDTF0a5JF5Oo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060886|imex:IM-23283-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:94B8BF966754A876|rigid:6xPdErS3+7qsYvFbrD30KZZLDw4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060886|imex:IM-23283-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:94B8BF966754A876|rigid:6xPdErS3+7qsYvFbrD30KZZLDw4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q6IAA8	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060894|imex:IM-23283-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:203CFDFCA7B2887E|rigid:6xPdErS3+7qsYvFbrD30KZZLDw4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q8NBW4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060894|imex:IM-23283-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:203CFDFCA7B2887E|rigid:6xPdErS3+7qsYvFbrD30KZZLDw4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q8NBW4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060923|imex:IM-23283-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:C563489E949F2BCB|rigid:undw8OdHJmYfQTsUqTKzuj1E7Kg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060921|imex:IM-23283-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:71E4DE93A01B69A1|rigid:undw8OdHJmYfQTsUqTKzuj1E7Kg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:Q9CQ22	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-8328730|uniprotkb:Q9CYS0|intact:MINT-1870311|intact:MINT-4124770|ensembl:ENSMUSP00000033131	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:ltor1_mouse(display_long)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Lamtor1(gene name)|psi-mi:Lamtor1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061077|imex:IM-23283-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_079881.2|ensembl:ENSMUSG00000030842(gene)|ensembl:ENSMUST00000033131(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR028209|mint:Q9CQ22|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6798695|reactome:R-MMU-8943724|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9639288	-	-	comment:mint	figure legend:Extended Data Figure 2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:DDzxcCbfpNbaFdldFxAR1QuFpXE10090	intact-crc:A6A7F983D5C3F984|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:O88653	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-1039530|ensembl:ENSMUSP00000130811|ensembl:ENSMUSP00000142512	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:ltor3_mouse(display_long)|uniprotkb:Map2k1ip1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:Lamtor3(gene name)|psi-mi:Lamtor3(display_short)|uniprotkb:Mapbp(gene name synonym)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:Mapksp1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061077|imex:IM-23283-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_064304.1|ensembl:ENSMUSG00000091512(gene)|ensembl:ENSMUST00000168345(transcript)|ensembl:ENSMUST00000197064(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005770"(late endosome)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|mint:O88653|rcsb pdb:1VET|rcsb pdb:1VEU|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:Extended Data Figure 2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:TSKaQ6Z8J4/87F1tOpftsh6xIvo10090	intact-crc:A6A7F983D5C3F984|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:Q8BGD6	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-10061052|uniprotkb:Q80W70|uniprotkb:Q8C5C3|ensembl:ENSMUSP00000052172	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:s38a9_mouse(display_long)|uniprotkb:Slc38a9(gene name)|psi-mi:Slc38a9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061077|imex:IM-23283-28	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_848861.1|refseq:XP_006517733.1|ensembl:ENSMUSG00000047789(gene)|ensembl:ENSMUST00000052514(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:Extended Data Figure 2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:c9C5L2LzhWIAoDmhEKt2EJ+D10Q10090	intact-crc:A6A7F983D5C3F984|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9UHA4	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061305|imex:IM-23283-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 3F|comment:Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC and, to a minor extent, RAGA, without significantly affecting LAMTOR1 and LAMTOR3 recruitment. Amino acid stimulation reduced the amount of recruited RAGC and RAGA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:8AF4F9FD00623B45|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061305|imex:IM-23283-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 3F|comment:Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC and, to a minor extent, RAGA, without significantly affecting LAMTOR1 and LAMTOR3 recruitment. Amino acid stimulation reduced the amount of recruited RAGC and RAGA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:8AF4F9FD00623B45|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9HB90	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061305|imex:IM-23283-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 3F|comment:Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC and, to a minor extent, RAGA, without significantly affecting LAMTOR1 and LAMTOR3 recruitment. Amino acid stimulation reduced the amount of recruited RAGC and RAGA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:8AF4F9FD00623B45|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061305|imex:IM-23283-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 3F|comment:Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC and, to a minor extent, RAGA, without significantly affecting LAMTOR1 and LAMTOR3 recruitment. Amino acid stimulation reduced the amount of recruited RAGC and RAGA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:8AF4F9FD00623B45|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060929|imex:IM-23283-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 1G, 2D, 2E Extended Data Figure 6B, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:92C8D28C64797E36|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:31-112|mutation disrupting interaction strength:38-40|mutation disrupting interaction strength:70-73|mutation disrupting interaction strength:85-87	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9HB90	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060929|imex:IM-23283-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 1G, 2D, 2E Extended Data Figure 6B, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:92C8D28C64797E36|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:31-112|mutation disrupting interaction strength:38-40|mutation disrupting interaction strength:70-73|mutation disrupting interaction strength:85-87	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9UHA4	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060929|imex:IM-23283-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 1G, 2D, 2E Extended Data Figure 6B, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:92C8D28C64797E36|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:31-112|mutation disrupting interaction strength:38-40|mutation disrupting interaction strength:70-73|mutation disrupting interaction strength:85-87	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060929|imex:IM-23283-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig. 1G, 2D, 2E Extended Data Figure 6B, 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:92C8D28C64797E36|rigid:S1MXIKRdc7ys6JMtVcZ6Owh+W3s	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:31-112|mutation disrupting interaction strength:38-40|mutation disrupting interaction strength:70-73|mutation disrupting interaction strength:85-87	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9HB90	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061491|imex:IM-23283-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig 3G|comment:"Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC without significantly affecting LAMTOR1 recruitment. Amino acid stimulation reduced the amount of recruited RAGC. Amino acid sensitivity required the transmembrane region (120-561) of SLC38A9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:7A42BBEA2069190F|rigid:pDy3LCr1rTw+vpvTG+rrLCPydwc	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:1-112	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q6IAA8	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061491|imex:IM-23283-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	intact:EBI-9975668(intact-secondary)	-	-	figure legend:Fig 3G|comment:"Amino acid starvation strengthened the interaction between SLC38A9 and endogenous RAGC without significantly affecting LAMTOR1 recruitment. Amino acid stimulation reduced the amount of recruited RAGC. Amino acid sensitivity required the transmembrane region (120-561) of SLC38A9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:7A42BBEA2069190F|rigid:pDy3LCr1rTw+vpvTG+rrLCPydwc	false	strep ii tag:n-n|ha tag:n-n|sufficient binding region:1-112	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q9UHA4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060871|imex:IM-23283-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:6082829A8E612773|rigid:chJ/eMZ2HcYWnwyVN8QmAWsWgHs	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q8NBW4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060871|imex:IM-23283-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:6082829A8E612773|rigid:chJ/eMZ2HcYWnwyVN8QmAWsWgHs	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UHA4	uniprotkb:Q8NBW4	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060958|imex:IM-23283-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:B4E31A74D2402CE0|rigid:aSSi6FEN8OiVQYmC5o/1T6pIpmg	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q8N122	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061661|imex:IM-23283-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:29F8B7125820D4DB|rigid:R5r2tMqQEzPRTOx0y7qxF2nbfiA	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q9HB90	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061661|imex:IM-23283-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:29F8B7125820D4DB|rigid:R5r2tMqQEzPRTOx0y7qxF2nbfiA	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q9UHA4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061661|imex:IM-23283-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:29F8B7125820D4DB|rigid:R5r2tMqQEzPRTOx0y7qxF2nbfiA	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q6IAA8	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061661|imex:IM-23283-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:29F8B7125820D4DB|rigid:R5r2tMqQEzPRTOx0y7qxF2nbfiA	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061623|imex:IM-23283-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGB glu99ala mutation decreased SLC38A9 binding but had no effect on any other interactors. A RRAGB thr54ala mutation increased SLC38A9 binding and appeared to decrease RAPTOR binding. RRAGC gln120ala mutant appeared to deceare Lamptor binding but was compensated for by a RRAGB Thr54ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:D183E4F4C91CBCF6|rigid:mwZpd3R93HtQdV39UAPQU1/Y2l0	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061623|imex:IM-23283-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGB glu99ala mutation decreased SLC38A9 binding but had no effect on any other interactors. A RRAGB thr54ala mutation increased SLC38A9 binding and appeared to decrease RAPTOR binding. RRAGC gln120ala mutant appeared to deceare Lamptor binding but was compensated for by a RRAGB Thr54ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:D183E4F4C91CBCF6|rigid:mwZpd3R93HtQdV39UAPQU1/Y2l0	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061623|imex:IM-23283-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGB glu99ala mutation decreased SLC38A9 binding but had no effect on any other interactors. A RRAGB thr54ala mutation increased SLC38A9 binding and appeared to decrease RAPTOR binding. RRAGC gln120ala mutant appeared to deceare Lamptor binding but was compensated for by a RRAGB Thr54ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:D183E4F4C91CBCF6|rigid:mwZpd3R93HtQdV39UAPQU1/Y2l0	false	ha tag:n-n|strep ii tag:n-n	ha tag:n-n|strep ii tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8N122	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061623|imex:IM-23283-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGB glu99ala mutation decreased SLC38A9 binding but had no effect on any other interactors. A RRAGB thr54ala mutation increased SLC38A9 binding and appeared to decrease RAPTOR binding. RRAGC gln120ala mutant appeared to deceare Lamptor binding but was compensated for by a RRAGB Thr54ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:D183E4F4C91CBCF6|rigid:mwZpd3R93HtQdV39UAPQU1/Y2l0	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8NBW4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061623|imex:IM-23283-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Extended Data Figure 8|comment:A RRAGB glu99ala mutation decreased SLC38A9 binding but had no effect on any other interactors. A RRAGB thr54ala mutation increased SLC38A9 binding and appeared to decrease RAPTOR binding. RRAGC gln120ala mutant appeared to deceare Lamptor binding but was compensated for by a RRAGB Thr54ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:D183E4F4C91CBCF6|rigid:mwZpd3R93HtQdV39UAPQU1/Y2l0	false	ha tag:n-n|strep ii tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q0VGL1	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-5658976|ensembl:ENSP00000343118	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor4_human(display_long)|uniprotkb:LAMTOR4(gene name)|psi-mi:LAMTOR4(display_short)|uniprotkb:C7orf59(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060966|imex:IM-23283-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	dip:DIP-61481N|refseq:NP_001008396.1|refseq:XP_016867687.1|ensembl:ENSG00000188186(gene)|ensembl:ENST00000341942(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0008361"(regulation of cell size)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR034601|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK5|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:IByB9Q3locB7cnKrbXVbaoCgvSk9606	intact-crc:BBE53898099914CD|rigid:56ate/CwdUvyPrZN0P5rv5Z97pI	false	-	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P21281	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8NBW4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P38606	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061267|imex:IM-23283-30	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Fig. 3E|comment:A further RRAGA thr21ala mutation had no additional effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606	intact-crc:56861E193B76AE15|rigid:BQ0C1jcXyh5xxZjhD9dMH0yxI6U	false	strep ii tag:n-n|ha tag:n-n|mutation:120-120	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P38606	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8N122	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P21281	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061144|imex:IM-23283-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Fig. 3E|comment:Levels of Raptor binding appeared to increase. A further gln66ala mutation of RRAGA had no additional effect.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:DE0CA9E0C84F015C|rigid:1i8vHxKQRyoL2lky8rFMpTbtMiY	false	ha tag:n-n|strep ii tag:n-n|mutation:75-75	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q8NBW4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10087258|imex:IM-23283-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:2C6B8D252858EF04|rigid:undw8OdHJmYfQTsUqTKzuj1E7Kg	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6IAA8	uniprotkb:Q8NBW4	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060950|imex:IM-23283-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:5A9ED73F45D6CE3F|rigid:fEe9nq4i6LblQijUKKvW3tcW1+w	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:O43504	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-713382|uniprotkb:Q6IBD8|ensembl:ENSP00000473439	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:ltor5_human(display_long)|uniprotkb:LAMTOR5(gene name)|psi-mi:LAMTOR5(display_short)|uniprotkb:HBXIP(gene name synonym)|uniprotkb:Hepatitis B virus X-interacting protein(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5(gene name synonym)|uniprotkb:XIP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060974|imex:IM-23283-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006393.2|ensembl:ENSG00000134248(gene)|ensembl:ENST00000602318(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019079"(viral genome replication)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR024135|mint:O43504|rcsb pdb:3MS6|rcsb pdb:3MSH|rcsb pdb:5VOK|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y38|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:5YK3|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0061462"(protein localization to lysosome)|dip:DIP-61482N	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:p4hO3N/2WyUvZJzDxQVPtjPNdNY9606	intact-crc:B639A087A9DFECC3|rigid:KH9dXf36dfJQR+thYxGtg0p9tuo	false	-	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P21281	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-4290814|uniprotkb:Q14544|uniprotkb:Q15859|uniprotkb:B2R5Z3|uniprotkb:D3DSQ5|uniprotkb:Q96IR0|ensembl:ENSP00000276390	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vatb2_human(display_long)|uniprotkb:ATP6V1B2(gene name)|psi-mi:ATP6V1B2(display_short)|uniprotkb:ATP6B2(gene name synonym)|uniprotkb:VPP3(gene name synonym)|uniprotkb:Endomembrane proton pump 58 kDa subunit(gene name synonym)|uniprotkb:HO57(gene name synonym)|uniprotkb:Vacuolar proton pump subunit B 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001684.2|ensembl:ENSG00000147416(gene)|ensembl:ENST00000276390(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005723(ATPase, V1 complex, subunit B)|interpro:IPR020003|interpro:IPR022879|interpro:IPR027417|mint:P21281|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|dip:DIP-47433N	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:CikZS+29TqYLiADRWgVESqCpg689606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:P38606	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8N122	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1567928|uniprotkb:Q8N4V9|uniprotkb:Q8TB32|uniprotkb:Q9P2P3|uniprotkb:B2RN36|uniprotkb:C6KEF2|uniprotkb:F5H7J5|ensembl:ENSP00000307272	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rptor_human(display_long)|uniprotkb:"p150 target of rapamycin (TOR)-scaffold protein"(gene name synonym)|uniprotkb:RPTOR(gene name)|psi-mi:RPTOR(display_short)|uniprotkb:KIAA1303(gene name synonym)|uniprotkb:RAPTOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001156506.1|refseq:NP_065812.1|dip:DIP-39482N|ensembl:ENSG00000141564(gene)|ensembl:ENST00000306801(transcript)|go:"GO:0001002"(RNA polymerase III type 1 promoter sequence-specific DNA binding)|go:"GO:0001003"(RNA polymerase III type 2 promoter sequence-specific DNA binding)|go:"GO:0001006"(RNA polymerase III type 3 promoter sequence-specific DNA binding)|go:"GO:0001156"(TFIIIC-class transcription factor complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000357(HEAT)|interpro:IPR001680(WD40 repeat)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|mint:Q8N122|rcsb pdb:5H64|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:BOvNcQXqn9hLPxAZeCZhKWbwgOk9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	strep ii tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q8NBW4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060982|imex:IM-23283-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 3E|comment:A RRAGA gln66ala mutation decreased SLC38A9 binding to RRAGA but had no effect on any other interactors.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/19	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:41EE46B800CAE301|rigid:oExMiUGc7PmmxEF0ADB5xCS4SnY	false	strep ii tag:n-n|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q9HB90	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060990|imex:IM-23283-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293 flp-in)|taxid:9606(Homo sapiens)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	intact-crc:A807A3827E8EED95|rigid:bX3kK5E8Qut7JVr84RD3/zo4zwM	false	-	ha tag:n-n|strep ii tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NBW4	uniprotkb:Q7L523	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060908|imex:IM-23283-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/13	2015/01/16	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:7BCEA878DAF92564|rigid:undw8OdHJmYfQTsUqTKzuj1E7Kg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7L523	uniprotkb:Q8NBW4	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	intact:EBI-9978316|uniprotkb:B3KXV1|uniprotkb:B7Z7D0|uniprotkb:Q0P5S0|uniprotkb:Q6MZJ8|uniprotkb:A0A0A8K8P2|ensembl:ENSP00000316596|ensembl:ENSP00000380074	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:s38a9_human(display_long)|uniprotkb:URLC11(gene name synonym)|uniprotkb:Up-regulated in lung cancer 11(gene name synonym)|uniprotkb:SLC38A9(gene name)|psi-mi:SLC38A9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10060913|imex:IM-23283-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_001245215.1|refseq:NP_001245216.1|refseq:NP_775785.2|refseq:XP_006714600.1|refseq:XP_006714601.1|refseq:XP_006714602.1|refseq:XP_011541475.1|refseq:XP_011541476.1|dip:DIP-61480N|ensembl:ENSG00000177058(gene)|ensembl:ENST00000318672(transcript)|ensembl:ENST00000396865(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	-	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rogid:wB8tjYMegNixZ5yElpNUNChR46A9606	intact-crc:CF4AEA121A1F056C|rigid:undw8OdHJmYfQTsUqTKzuj1E7Kg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:Q9CQ22	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-8328730|uniprotkb:Q9CYS0|intact:MINT-1870311|intact:MINT-4124770|ensembl:ENSMUSP00000033131	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:ltor1_mouse(display_long)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Lamtor1(gene name)|psi-mi:Lamtor1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061023|imex:IM-23283-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_079881.2|ensembl:ENSMUSG00000030842(gene)|ensembl:ENSMUST00000033131(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0051020"(GTPase binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|interpro:IPR028209|mint:Q9CQ22|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-6798695|reactome:R-MMU-8943724|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423|reactome:R-MMU-9639288	-	-	comment:mint	figure legend:Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:DDzxcCbfpNbaFdldFxAR1QuFpXE10090	intact-crc:13471A02D7D22429|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:Q8BGD6	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-10061052|uniprotkb:Q80W70|uniprotkb:Q8C5C3|ensembl:ENSMUSP00000052172	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:s38a9_mouse(display_long)|uniprotkb:Slc38a9(gene name)|psi-mi:Slc38a9(display_short)|uniprotkb:Solute carrier family 38 member 9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061023|imex:IM-23283-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_848861.1|refseq:XP_006517733.1|ensembl:ENSMUSG00000047789(gene)|ensembl:ENSMUST00000052514(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015190"(L-leucine transmembrane transporter activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0061459"(L-arginine transmembrane transporter activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:c9C5L2LzhWIAoDmhEKt2EJ+D10Q10090	intact-crc:13471A02D7D22429|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q80X95	uniprotkb:O88653	intact:EBI-10061024|uniprotkb:B1AXR0|uniprotkb:Q8C1S2|uniprotkb:Q8CFU3|ensembl:ENSMUSP00000088591	intact:EBI-1039530|ensembl:ENSMUSP00000130811|ensembl:ENSMUSP00000142512	psi-mi:rraga_mouse(display_long)|uniprotkb:Rraga(gene name)|psi-mi:Rraga(display_short)	psi-mi:ltor3_mouse(display_long)|uniprotkb:Map2k1ip1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:Lamtor3(gene name)|psi-mi:Lamtor3(display_short)|uniprotkb:Mapbp(gene name synonym)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:Mapksp1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rebsamen et al. (2015)	pubmed:25561175|imex:IM-23283	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061023|imex:IM-23283-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_848463.1|ensembl:ENSMUSG00000070934(gene)|ensembl:ENSMUST00000091064(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042268"(regulation of cytolysis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043200"(response to amino acid)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990130"(GATOR1 complex)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8866654|reactome:R-MMU-8943724|reactome:R-MMU-9639288	refseq:NP_064304.1|ensembl:ENSMUSG00000091512(gene)|ensembl:ENSMUST00000168345(transcript)|ensembl:ENSMUST00000197064(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005770"(late endosome)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|mint:O88653|rcsb pdb:1VET|rcsb pdb:1VEU|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8943724|reactome:R-MMU-9639288	-	-	-	figure legend:Extended Data Figure 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2014/11/13	2015/01/16	rogid:1BxTVycwXop9+lViwQU5TyK/tlI10090	rogid:TSKaQ6Z8J4/87F1tOpftsh6xIvo10090	intact-crc:13471A02D7D22429|rigid:ZLw1rQOIu+VSXkEYlgLve3wZRRo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)