#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8X834	uniprotkb:Q05D32	intact:EBI-10039193|uniprotkb:Q7AGE2|ensemblbacteria:BAB34270|uniprotkb:A0A7U8R4U9|uniprotkb:A0A6M0JJK4|uniprotkb:A0A6M6W2Q6	intact:EBI-10039222|uniprotkb:Q3ZTU1|uniprotkb:Q6AI06|uniprotkb:Q8IYI9|uniprotkb:Q9NVT2|uniprotkb:Q9NZX8|uniprotkb:Q9P030|ensembl:ENSP00000260327|ensembl:ENSP00000452837	psi-mi:q8x834_eco57(display_long)|uniprotkb:E5F08_07745(orf name)|uniprotkb:nleC(gene name)|psi-mi:nleC(display_short)|uniprotkb:ECs_0847(orf name)	psi-mi:ctsl2_human(display_long)|uniprotkb:HSPC058(orf name)|uniprotkb:HSPC129(orf name)|uniprotkb:CTDSPL2(gene name)|psi-mi:CTDSPL2(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039220|imex:IM-23549-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR025208|rcsb pdb:4LGI|rcsb pdb:4LGJ|refseq:NP_308874.1|ensemblbacteria:BAB34270(transcript)|ensemblbacteria:ECs_0847(gene)|go:"GO:0046872"(metal ion binding)	refseq:NP_057480.2|refseq:XP_005254498.1|refseq:XP_006720628.1|ensembl:ENSG00000137770(gene)|ensembl:ENST00000260327(transcript)|ensembl:ENST00000558966(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR004274(NLI interacting factor)|interpro:IPR011948(Dullard-like phosphatase domain)|interpro:IPR023214|interpro:IPR036412	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/10/12	rogid:2YRFou+gcur7JjPuYwcTJn7Rrpo83334	rogid:hJqS+nt0dbuxyyr3etxclNYAZco9606	intact-crc:DFF24D643C154260|rigid:x+MOliNepmWeZDt+CFJkg8Gy/HY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37235	uniprotkb:Q7DB77	intact:EBI-749311|uniprotkb:Q969S5|ensembl:ENSP00000310749|ensembl:ENSP00000371184|ensembl:ENSP00000478231|ensembl:ENSP00000482993|ensembl:ENSP00000483786	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:hpcl1_human(display_long)|uniprotkb:Visinin-like protein 3(gene name synonym)|uniprotkb:Calcium-binding protein BDR-1(gene name synonym)|uniprotkb:HLP2(gene name synonym)|uniprotkb:HPCAL1(gene name)|psi-mi:HPCAL1(display_short)|uniprotkb:BDR1(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039499|imex:IM-23549-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002140.2|refseq:NP_602293.1|refseq:XP_011508648.1|refseq:XP_011508649.1|refseq:XP_011508650.1|refseq:NP_001245286.1|refseq:NP_001245287.1|refseq:NP_001245288.1|refseq:XP_005246217.1|refseq:XP_005246218.1|refseq:XP_005246219.1|refseq:XP_005246220.1|refseq:XP_016859439.1|refseq:XP_016859440.1|refseq:XP_016859441.1|refseq:XP_016859442.1|ensembl:ENSG00000115756(gene)|ensembl:ENST00000307845(transcript)|ensembl:ENST00000381765(transcript)|ensembl:ENST00000613496(transcript)|ensembl:ENST00000620771(transcript)|ensembl:ENST00000622018(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|rcsb pdb:5T7C	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:oK04sIDCtghEOWIBNQ75bR34+2o9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:315AC765FAD3E911|rigid:1cwDS9Ro06Jrm9ll7Abp4YUxFYM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A2A2Y4	uniprotkb:Q8XAJ5	intact:EBI-6911547|uniprotkb:Q8N9L2|uniprotkb:Q53EP2|uniprotkb:Q5JV59|uniprotkb:A8MQB0|uniprotkb:B4DN14|uniprotkb:Q8IZ44|uniprotkb:Q5VZA1|uniprotkb:Q8N3Y5|uniprotkb:Q86WP8|ensembl:ENSP00000303508	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	psi-mi:frmd3_human(display_long)|uniprotkb:Band 4.1-like protein 4O(gene name synonym)|uniprotkb:EPB41L4O(gene name synonym)|uniprotkb:Ovary type protein 4.1(gene name synonym)|uniprotkb:FRMD3(gene name)|psi-mi:FRMD3(display_short)	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039131|imex:IM-23549-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001231888.1|refseq:NP_001231889.1|refseq:NP_001231890.1|refseq:NP_001231891.1|refseq:NP_777598.3|ensembl:ENST00000304195(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031032"(actomyosin structure organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|ensembl:ENSG00000172159(gene)|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:mhyjQ1Yy8dmn8JseI7ehX//yySw9606	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	intact-crc:E9D668E2926737ED|rigid:kms1NOgh7ZGGd3jJyLXtwhDJQr0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAJ5	uniprotkb:P56555	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	intact:EBI-10039117|uniprotkb:Q4VB31	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:dscr4_human(display_long)|uniprotkb:DSCR4(gene name)|psi-mi:DSCR4(display_short)|uniprotkb:DCRB(gene name synonym)|uniprotkb:DSCRB(gene name synonym)|uniprotkb:Down syndrome critical region protein B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039115|imex:IM-23549-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	refseq:NP_005858.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	rogid:ObILr2wYLN3Wg8advbNI6ZaAta89606	intact-crc:2999072E24E271F5|rigid:FcSGEjJGaaly873gwKO+F9MXyfs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P55039	uniprotkb:Q8XBX8	intact:EBI-750565|uniprotkb:Q9BWB2|uniprotkb:B2R8G5|uniprotkb:Q53Y50|ensembl:ENSP00000225729	intact:EBI-10039153|uniprotkb:Q7AAV0|ensemblbacteria:BAB37280|ensemblbacteria:QCH81151|uniprotkb:A0A0H3JHS6|uniprotkb:A0A6M0JF43	psi-mi:drg2_human(display_long)|uniprotkb:DRG2(gene name)|psi-mi:DRG2(display_short)|uniprotkb:Translation factor GTPase DRG2(gene name synonym)	psi-mi:nleb1_eco57(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:ECs_3857(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039161|imex:IM-23549-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001379.1|ensembl:ENSG00000108591(gene)|ensembl:ENST00000225729(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|interpro:IPR012676(TGS-like)	refseq:NP_311884.1|refseq:WP_000953022.1|ensemblbacteria:BAB37280(transcript)|ensemblbacteria:CAM50_0004305(gene)|ensemblbacteria:ECs_3857(gene)|ensemblbacteria:QCH81151(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9bgX8C0kJmO5KdaYHU+vAmDCTPo9606	rogid:s08ivrjNoMdHHNcIwH+V7ZobNOQ83334	intact-crc:AEE8FEF396A5B08C|rigid:dD+KM+yBSkP8/jr7kNRM9Vf95Rw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43257	uniprotkb:Q8XA11	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039022|imex:IM-23549-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:E907E999DFB54036|rigid:ZKzZi/Z6g5p/LPvOaXKz67zdspg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8X834	uniprotkb:Q9Y4M8	intact:EBI-10039193|uniprotkb:Q7AGE2|ensemblbacteria:BAB34270|uniprotkb:A0A7U8R4U9|uniprotkb:A0A6M0JJK4|uniprotkb:A0A6M6W2Q6	intact:EBI-10039207	psi-mi:q8x834_eco57(display_long)|uniprotkb:E5F08_07745(orf name)|uniprotkb:nleC(gene name)|psi-mi:nleC(display_short)|uniprotkb:ECs_0847(orf name)	psi-mi:ch071_human(display_long)|uniprotkb:LINC00588(gene name)|psi-mi:LINC00588(display_short)|uniprotkb:C8orf71(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039205|imex:IM-23549-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR025208|rcsb pdb:4LGI|rcsb pdb:4LGJ|refseq:NP_308874.1|ensemblbacteria:BAB34270(transcript)|ensemblbacteria:ECs_0847(gene)|go:"GO:0046872"(metal ion binding)	-	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/10/12	rogid:2YRFou+gcur7JjPuYwcTJn7Rrpo83334	rogid:24v/Quf+HxPH2yvmmV5uFTFhZxw9606	intact-crc:64BE4259476D211B|rigid:ghnYVKZPaXkwQ+NDJyGINYnnd0E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XA11	uniprotkb:Q6Y2X3	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-10038974|uniprotkb:A5YM67|uniprotkb:Q17RY2|uniprotkb:Q66K17|uniprotkb:Q96N59|uniprotkb:Q96T63|ensembl:ENSP00000317500|ensembl:ENSP00000350223|ensembl:ENSP00000448876|ensembl:ENSP00000450196|ensembl:ENSP00000504134	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:djc14_human(display_long)|uniprotkb:DNAJC14(gene name)|psi-mi:DNAJC14(display_short)|uniprotkb:DRIP78(gene name synonym)|uniprotkb:HDJ3(gene name synonym)|uniprotkb:DnaJ protein homolog 3(gene name synonym)|uniprotkb:Dopamine receptor-interacting protein of 78 kDa(gene name synonym)|uniprotkb:Human DnaJ protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039004|imex:IM-23549-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_115740.5|ensembl:ENSG00000135392(gene)|ensembl:ENST00000317287(transcript)|ensembl:ENST00000357606(transcript)|ensembl:ENST00000546957(transcript)|ensembl:ENST00000547445(transcript)|ensembl:ENST00000678005(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR032843|interpro:IPR036869|mint:Q6Y2X3	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:oS3c968UKq0i0JRZxUJFskA5HD89606	intact-crc:8A7B63EED59B0871|rigid:zrdoJVyFVTprLL5aBAyHrVWpLOk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XC86	uniprotkb:Q9BYM8	intact:EBI-10038594|uniprotkb:Q7A9Q6|ensemblbacteria:BAB37977|ensemblbacteria:QCH80454|uniprotkb:A0A0H3JJC8|uniprotkb:A0A6M0JLD0	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	psi-mi:q8xc86_eco57(display_long)|uniprotkb:E5F08_27370(orf name)|uniprotkb:espB(gene name)|psi-mi:espB(display_short)|uniprotkb:ECs_4554(orf name)	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038604|imex:IM-23549-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008611(Enterobacterial EspB)|refseq:NP_312581.1|refseq:WP_001092000.1|ensemblbacteria:BAB37977(transcript)|ensemblbacteria:CAM50_0000445(gene)|ensemblbacteria:ECs_4554(gene)|ensemblbacteria:QCH80454(transcript)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9cKWrLKb1089HnklaM95O3OLdTQ83334	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	intact-crc:38C381B939FEFA8B|rigid:Cr3FpGA3wpV+Ewb6qFIbZAB7y2g	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB77	uniprotkb:O43924	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-712685|uniprotkb:O43250|ensembl:ENSP00000287600	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:pde6d_human(display_long)|uniprotkb:Protein p17(gene name synonym)|uniprotkb:PDE6D(gene name)|psi-mi:PDE6D(display_short)|uniprotkb:PDED(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039512|imex:IM-23549-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001277947.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050896"(response to stimulus)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017287(Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit)|interpro:IPR037036|mint:O43924|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:3T5G|rcsb pdb:3T5I|rcsb pdb:4JHP|rcsb pdb:4JV6|rcsb pdb:4JV8|rcsb pdb:4JVB|rcsb pdb:4JVF|rcsb pdb:5E80|rcsb pdb:5E8F|rcsb pdb:5F2U|rcsb pdb:5ML2|rcsb pdb:5ML3|rcsb pdb:5ML4|rcsb pdb:5ML6|rcsb pdb:5ML8|rcsb pdb:5NAL|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5X72|rcsb pdb:5X73|rcsb pdb:5X74|rcsb pdb:5YAV|rcsb pdb:5YAW|reactome:R-HSA-5624958|ensembl:ENSG00000156973(gene)|ensembl:ENST00000287600(transcript)|go:"GO:0005095"(GTPase inhibitor activity)|reactome:R-HSA-9648002|refseq:NP_002592.1|dip:DIP-36660N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:dfEOckvNZPhkWSeQnKr4ugEdEmM9606	intact-crc:7AD1C2DE9090A51C|rigid:nSx3EzGVFU/94uLHaqDzzak+8G8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DJ88	uniprotkb:Q68DY1	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	intact:EBI-1640399|uniprotkb:Q8N8T4|uniprotkb:Q96QM1|ensembl:ENSP00000469958	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:zn626_human(display_long)|uniprotkb:ZNF626(gene name)|psi-mi:ZNF626(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039475|imex:IM-23549-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	refseq:NP_001070143.1|refseq:NP_660340.1|ensembl:ENSG00000188171(gene)|ensembl:ENST00000601440(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436	-	caution:This sequence has been withdrawn from Uniprot.	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rogid:tF3sX34c5wSVHW6nCDA2edNG6hg9606	intact-crc:02EABB84DEFB55E2|rigid:pD9kpgdQB2avZ5vudg31ytsFOP4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB77	uniprotkb:Q9UQB8	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039889|imex:IM-23549-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	intact-crc:E0DB7D9D9EA4C1FD|rigid:+FInGdMTTBxacaG2SJDoullzsRQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAL7	uniprotkb:P05204	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-1758689|uniprotkb:Q0VGD5|uniprotkb:Q6FGI5|uniprotkb:Q96C64|ensembl:ENSP00000355228|ensembl:ENSP00000481160	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:hmgn2_human(display_long)|uniprotkb:HMGN2(gene name)|psi-mi:HMGN2(display_short)|uniprotkb:HMG17(gene name synonym)|uniprotkb:High mobility group nucleosome-binding domain-containing protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040179|imex:IM-23549-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_005508.1|ensembl:ENSG00000198830(gene)|ensembl:ENST00000361427(transcript)|ensembl:ENST00000619352(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR000079(High mobility group protein HMG14 and HMG17)|mint:P05204	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:j8Khsp7BUJh0L9SicpVNR8LP6ZU9606	intact-crc:65019FCDB18E48E3|rigid:PF/SuX8AHZOi79VBEk4FrlTd2hE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8N456	uniprotkb:Q8XBX8	intact:EBI-751373|uniprotkb:Q6UY02|ensembl:ENSP00000363275	intact:EBI-10039153|uniprotkb:Q7AAV0|ensemblbacteria:BAB37280|ensemblbacteria:QCH81151|uniprotkb:A0A0H3JHS6|uniprotkb:A0A6M0JF43	psi-mi:lrc18_human(display_long)|uniprotkb:LRRC18(gene name)|psi-mi:LRRC18(display_short)|uniprotkb:UNQ9338/PRO34010(orf name)	psi-mi:nleb1_eco57(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:ECs_3857(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039173|imex:IM-23549-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006940.3|refseq:XP_011538124.1|refseq:XP_011538125.1|refseq:XP_011538128.1|refseq:XP_011538130.1|refseq:XP_011538131.1|refseq:XP_006717930.1|refseq:XP_016871765.1|refseq:XP_016871766.1|ensembl:ENSG00000165383(gene)|ensembl:ENST00000374160(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675	refseq:NP_311884.1|refseq:WP_000953022.1|ensemblbacteria:BAB37280(transcript)|ensemblbacteria:CAM50_0004305(gene)|ensemblbacteria:ECs_3857(gene)|ensemblbacteria:QCH81151(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:gKc5evWyzPYpUr8KIzDu4I9Oy4A9606	rogid:s08ivrjNoMdHHNcIwH+V7ZobNOQ83334	intact-crc:ECE9FDF6596F3CB0|rigid:pzu4CXPHcWRY1b3GSazXdFoXPU4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAJ5	uniprotkb:P01210	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	intact:EBI-6656032|ensembl:ENSP00000324248|ensembl:ENSP00000400894|uniprotkb:B2RC23|uniprotkb:Q6FHC6|uniprotkb:Q6FHE6	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:penk_human(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039135|imex:IM-23549-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	ensembl:ENSG00000181195(gene)|ensembl:ENST00000314922(transcript)|ensembl:ENST00000451791(transcript)|go:"GO:0001515"(opioid peptide activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0002118"(aggressive behavior)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007600"(sensory perception)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034592"(synaptic vesicle lumen)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043679"(axon terminus)|go:"GO:0045471"(response to ethanol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0031628"(opioid receptor binding)|go:"GO:0099013"(neuronal dense core vesicle lumen)|go:"GO:0099538"(synaptic signaling via neuropeptide)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000703(Proenkephalin A)|interpro:IPR006024(Opioid neuropeptide precursor)|rcsb pdb:1PLW|rcsb pdb:1PLX|rcsb pdb:2LWC|rcsb pdb:5E33|rcsb pdb:5E3A|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0098586"(cellular response to virus)|refseq:NP_001129162.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	rogid:xL8ujOb7RFDy5+t+Oe/ph/XOoOM9606	intact-crc:C803CE1A5B4BE085|rigid:KpaHhap6NOsiixUq12D75qNbINA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB76	uniprotkb:Q8TCX5	intact:EBI-10039068|uniprotkb:Q7A9Q0|ensemblbacteria:BAB37985|uniprotkb:A0A0H3JJD5|uniprotkb:A0A6M0JL37	intact:EBI-746325|uniprotkb:Q8TAV1|uniprotkb:Q96PV9|ensembl:ENSP00000289013|intact:EBI-12011872	psi-mi:q7db76_eco57(display_long)|uniprotkb:E5F08_27410(orf name)|uniprotkb:map(gene name)|psi-mi:map(display_short)|uniprotkb:ECs_4562(orf name)	psi-mi:rhpn1_human(display_long)|uniprotkb:KIAA1929(gene name synonym)|uniprotkb:GTP-Rho-binding protein 1(gene name synonym)|uniprotkb:RHPN1(gene name)|psi-mi:RHPN1(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039066|imex:IM-23549-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004959(IpaB/EvcA)|refseq:NP_312589.1|refseq:WP_000492638.1|ensemblbacteria:BAB37985(transcript)|ensemblbacteria:ECs_4562(gene)	interpro:IPR036274|interpro:IPR042715|reactome:R-HSA-5666185|reactome:R-HSA-8980692|ensembl:ENSG00000158106(gene)|ensembl:ENST00000289013(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004328(BRO1)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR036034|refseq:NP_443156.2	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/09/18	rogid:xO5ymWP2ug1VLyxelIaeen+24gM83334	rogid:EF1IVH0DLg/1KL4iWFVBktsl5589606	intact-crc:6D70E514A0550C81|rigid:0Yiwj0imHykFHVs92LsiUMA6cao	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAJ5	uniprotkb:Q93096	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	intact:EBI-1058467|uniprotkb:O00648|uniprotkb:Q49A54|uniprotkb:B2R6C8|intact:EBI-1640492|ensembl:ENSP00000485687|ensembl:ENSP00000497588|ensembl:ENSP00000500859|ensembl:ENSP00000500952	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:tp4a1_human(display_long)|uniprotkb:PTP4A1(gene name)|psi-mi:PTP4A1(display_short)|uniprotkb:PRL1(gene name synonym)|uniprotkb:PTPCAAX1(gene name synonym)|uniprotkb:"PTP(CAAXI)"(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 4a1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase of regenerating liver 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039139|imex:IM-23549-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	refseq:NP_003454.1|ensembl:ENSG00000112245(gene)|ensembl:ENST00000626021(transcript)|ensembl:ENST00000648894(transcript)|ensembl:ENST00000672924(transcript)|ensembl:ENST00000673199(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1RXD|rcsb pdb:1XM2|rcsb pdb:5BX1|refseq:XP_016866759.1|refseq:XP_016866760.1|refseq:XP_011534413.1|refseq:XP_011534414.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	rogid:Eza5NsYNd+5ml6QEEmkQv5pAZ789606	intact-crc:050D553DB0FE8F20|rigid:34CyLoE6+8jRAPYLPlLJhU14uWc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XA11	uniprotkb:Q9NWS0	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039014|imex:IM-23549-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606	intact-crc:CFBC78E54799FC03|rigid:BOQdiS8j1wlzSuTh62U6lJGzrzo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15599	uniprotkb:Q7DB76	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	intact:EBI-10039068|uniprotkb:Q7A9Q0|ensemblbacteria:BAB37985|uniprotkb:A0A0H3JJD5|uniprotkb:A0A6M0JL37	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:q7db76_eco57(display_long)|uniprotkb:E5F08_27410(orf name)|uniprotkb:map(gene name)|psi-mi:map(display_short)|uniprotkb:ECs_4562(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039081|imex:IM-23549-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N	interpro:IPR004959(IpaB/EvcA)|refseq:NP_312589.1|refseq:WP_000492638.1|ensemblbacteria:BAB37985(transcript)|ensemblbacteria:ECs_4562(gene)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	rogid:xO5ymWP2ug1VLyxelIaeen+24gM83334	intact-crc:776779C89E84E764|rigid:ZFQ2ER4vDnTY3j2m0nmj7IjFPoQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20807	uniprotkb:Q8XA11	intact:EBI-5655000|ensembl:ENSP00000380349|uniprotkb:Q9Y5S6|uniprotkb:Q9Y5S7|uniprotkb:Q9BTU4|uniprotkb:A6H8K6|uniprotkb:Q7L4R0|uniprotkb:Q9BQC8	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:can3_human(display_long)|uniprotkb:CANP3(gene name synonym)|uniprotkb:CANPL3(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:NCL1(gene name synonym)|uniprotkb:New calpain 1(gene name synonym)|uniprotkb:CAPN3(gene name)|psi-mi:CAPN3(display_short)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038917|imex:IM-23549-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092529(gene)|ensembl:ENST00000397163(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|refseq:NP_000061.1|refseq:NP_077320.1|refseq:NP_775110.1|refseq:NP_775111.1|refseq:NP_775112.1|refseq:NP_775113.1|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P20807|rcsb pdb:1Y9V|rcsb pdb:4OKH|rcsb pdb:6BDT|rcsb pdb:6BGP|rcsb pdb:6BJD|rcsb pdb:6BKJ|reactome:R-HSA-1474228	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:niIxeCH+wcEYovZ1/3/zTO27bOU9606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:EE396447DDC815A4|rigid:5aDXr/CU6pc4B6YyM+GJJg7B2LI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A0A0H3JFN8	uniprotkb:Q9UK73	intact:EBI-10038897|ensemblbacteria:BAB34990|ensemblbacteria:QCH83279|uniprotkb:A0A4P8BA24	intact:EBI-310482|uniprotkb:O43146|ensembl:ENSP00000307298	psi-mi:a0a0h3jfn8_eco57(display_long)|uniprotkb:E5F08_11480(orf name)|uniprotkb:espO1-1(gene name)|psi-mi:espO1-1(display_short)|uniprotkb:ECs_1567(orf name)	psi-mi:fem1b_human(display_long)|uniprotkb:FEM1B(gene name)|psi-mi:FEM1B(display_short)|uniprotkb:KIAA0396(gene name synonym)|uniprotkb:F1AA(gene name synonym)|uniprotkb:FEM1-beta(gene name synonym)|uniprotkb:Fem-1-like death receptor-binding protein alpha(gene name synonym)|uniprotkb:Fem-1-like in apoptotic pathway protein alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038902|imex:IM-23549-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q8X3G1(uniprot-removed-ac)|refseq:NP_309594.1|refseq:WP_001303921.1|ensemblbacteria:BAB34990(transcript)|ensemblbacteria:CAM50_0016380(gene)|ensemblbacteria:ECs_1567(gene)|ensemblbacteria:QCH83279(transcript)	refseq:NP_056137.1|ensembl:ENSG00000169018(gene)|ensembl:ENST00000306917(transcript)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6LBF|rcsb pdb:7CNG|rcsb pdb:7EL6|reactome:R-HSA-8951664|go:"GO:2000001"(regulation of DNA damage checkpoint)|dip:DIP-31663N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:xkpMwN9ZoiqOVRPjfxcowfXdmbk83334	rogid:ODOxw01NrJ8fUJv2XopsdTYtAr49606	intact-crc:E663C2D9655D8A0E|rigid:pbujLiJp+Q7BJEt7OA0edUpkim4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96HT8	uniprotkb:Q8XB62	intact:EBI-748896|uniprotkb:Q6NXT8|uniprotkb:Q9P0J5|uniprotkb:B2R6R0|ensembl:ENSP00000318154	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	psi-mi:mr1l1_human(display_long)|uniprotkb:PP784(orf name)|uniprotkb:MRFAP1L1(gene name)|psi-mi:MRFAP1L1(display_short)	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038835|imex:IM-23549-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_982287.1|refseq:XP_005247989.1|ensembl:ENSG00000178988(gene)|ensembl:ENST00000320848(transcript)|go:"GO:0042802"(identical protein binding)|interpro:IPR029254|mint:Q96HT8|dip:DIP-29019N	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:6C914B0B4BEECAE5	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:hb4enqSS7DeieOByDoLDkXkSlIk9606	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	intact-crc:53E4E672CB97605B|rigid:B4DOPbQLC1N4Bvf5sgdEq9FpAVo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XA11	uniprotkb:Q5JVF3	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-1051701|uniprotkb:A6NK09|uniprotkb:Q3ZCX1|uniprotkb:Q5TC57|uniprotkb:Q5TC58|uniprotkb:Q9H7K1|uniprotkb:Q9HBZ7|uniprotkb:Q9NUK6|uniprotkb:Q9NVY1|uniprotkb:Q9NW44|uniprotkb:Q9NWH3|ensembl:ENSP00000337405|ensembl:ENSP00000364626|ensembl:ENSP00000364628	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:pcid2_human(display_long)|uniprotkb:CSN12-like protein(gene name synonym)|uniprotkb:PCID2(gene name)|psi-mi:PCID2(display_short)|uniprotkb:HT004(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039010|imex:IM-23549-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_001120674.1|refseq:NP_001120675.1|refseq:NP_060856.2|refseq:NP_001245142.1|refseq:NP_001307584.1|refseq:NP_001307585.1|refseq:NP_001307586.1|refseq:NP_001307589.1|ensembl:ENSG00000126226(gene)|ensembl:ENST00000337344(transcript)|ensembl:ENST00000375477(transcript)|ensembl:ENST00000375479(transcript)|go:"GO:0000973"(posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0015031"(protein transport)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048536"(spleen development)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071033"|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|rcsb pdb:3T5X|refseq:XP_016876153.1|dip:DIP-50497N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:jFHv4Xifu2Qw/CzD5SKl3PgJpgE9606	intact-crc:F8AE79E7EB473837|rigid:yf4oiTDQLpGkLd2aLg559p06zR8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75716	uniprotkb:Q8XC86	intact:EBI-749295|uniprotkb:Q96KI2|uniprotkb:Q9UEN3|uniprotkb:Q9UP78|uniprotkb:A8K9H9|uniprotkb:Q5U0F8|intact:EBI-1046308|uniprotkb:Q9BUH4|ensembl:ENSP00000379964|ensembl:ENSP00000386928	intact:EBI-10038594|uniprotkb:Q7A9Q6|ensemblbacteria:BAB37977|ensemblbacteria:QCH80454|uniprotkb:A0A0H3JJC8|uniprotkb:A0A6M0JLD0	psi-mi:stk16_human(display_long)|uniprotkb:STK16(gene name)|psi-mi:STK16(display_short)|uniprotkb:MPSK1(gene name synonym)|uniprotkb:PKL12(gene name synonym)|uniprotkb:TSF1(gene name synonym)|uniprotkb:Protein kinase PKL12(gene name synonym)|uniprotkb:Myristoylated and palmitoylated serine/threonine-protein kinase(gene name synonym)|uniprotkb:TGF-beta-stimulated factor 1(gene name synonym)|uniprotkb:hPSK(gene name synonym)|uniprotkb:Tyrosine-protein kinase STK16(gene name synonym)	psi-mi:q8xc86_eco57(display_long)|uniprotkb:E5F08_27370(orf name)|uniprotkb:espB(gene name)|psi-mi:espB(display_short)|uniprotkb:ECs_4554(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038684|imex:IM-23549-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008910.1|refseq:NP_001317142.1|ensembl:ENSG00000115661(gene)|ensembl:ENST00000396738(transcript)|ensembl:ENST00000409638(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2BUJ|dip:DIP-29598N	interpro:IPR008611(Enterobacterial EspB)|refseq:NP_312581.1|refseq:WP_001092000.1|ensemblbacteria:BAB37977(transcript)|ensemblbacteria:CAM50_0000445(gene)|ensemblbacteria:ECs_4554(gene)|ensemblbacteria:QCH80454(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9eLCQQQFtAQVj2MUxyDLGkniiM49606	rogid:9cKWrLKb1089HnklaM95O3OLdTQ83334	intact-crc:9BA3EAC33DC2128A|rigid:TWTXO50+iq2Mr2haSEv0la8mxI0	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WV41	uniprotkb:Q7DB85	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038720|imex:IM-23549-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	intact-crc:F415EA0FF2FC834B|rigid:EJWElMHIfoLZPiYqkhIBXyoQTjI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75716	uniprotkb:Q7DB77	intact:EBI-749295|uniprotkb:Q96KI2|uniprotkb:Q9UEN3|uniprotkb:Q9UP78|uniprotkb:A8K9H9|uniprotkb:Q5U0F8|intact:EBI-1046308|uniprotkb:Q9BUH4|ensembl:ENSP00000379964|ensembl:ENSP00000386928	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:stk16_human(display_long)|uniprotkb:STK16(gene name)|psi-mi:STK16(display_short)|uniprotkb:MPSK1(gene name synonym)|uniprotkb:PKL12(gene name synonym)|uniprotkb:TSF1(gene name synonym)|uniprotkb:Protein kinase PKL12(gene name synonym)|uniprotkb:Myristoylated and palmitoylated serine/threonine-protein kinase(gene name synonym)|uniprotkb:TGF-beta-stimulated factor 1(gene name synonym)|uniprotkb:hPSK(gene name synonym)|uniprotkb:Tyrosine-protein kinase STK16(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039518|imex:IM-23549-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008910.1|refseq:NP_001317142.1|ensembl:ENSG00000115661(gene)|ensembl:ENST00000396738(transcript)|ensembl:ENST00000409638(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2BUJ|dip:DIP-29598N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9eLCQQQFtAQVj2MUxyDLGkniiM49606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:AA1F0CD7443085A7|rigid:PtFZg2M0P8t6pPCwD5zeyLdixIc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB77	uniprotkb:Q9UM19	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-744820|uniprotkb:Q5TG97|uniprotkb:Q8N611|uniprotkb:B2R5U2|uniprotkb:D3DPU1|ensembl:ENSP00000361935|ensembl:ENSP00000481834	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:hpcl4_human(display_long)|uniprotkb:HPCAL4(gene name)|psi-mi:HPCAL4(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039504|imex:IM-23549-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_057341.1|ensembl:ENSG00000116983(gene)|ensembl:ENST00000617690(transcript)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR029534|ensembl:ENST00000372844(transcript)|refseq:NP_001269325.1|refseq:XP_016856936.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:+2KFQ7WO9Kyn14ySKaEmm1V6pRM9606	intact-crc:8A99CCA0B95F7B76|rigid:1IogbQyoEvXFZXTvTXzoGXPvL0A	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAL6	uniprotkb:Q9Y3C8	intact:EBI-10039443|uniprotkb:Q7AEN0|ensemblbacteria:BAB35237|ensemblbacteria:QCH82723|uniprotkb:A0A0H3JE77|uniprotkb:A0A6M0JRG2	intact:EBI-1045733|uniprotkb:Q5VTX1|uniprotkb:Q549X0|uniprotkb:Q9BS96|uniprotkb:Q9P009|uniprotkb:D3DVF9|uniprotkb:A8K9R1|ensembl:ENSP00000356982	psi-mi:q8xal6_eco57(display_long)|uniprotkb:E5F08_14920(orf name)|uniprotkb:nleH1_2(gene name)|psi-mi:nleH1_2(display_short)|uniprotkb:ECs_1814(orf name)	psi-mi:ufc1_human(display_long)|uniprotkb:UFC1(gene name)|psi-mi:UFC1(display_short)|uniprotkb:CGI-126(orf name)|uniprotkb:HSPC155(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039453|imex:IM-23549-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309841.1|refseq:WP_000950979.1|ensemblbacteria:BAB35237(transcript)|ensemblbacteria:CAM50_0013205(gene)|ensemblbacteria:ECs_1814(gene)|ensemblbacteria:QCH82723(transcript)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0052055"(modulation by symbiont of host molecular function)|rcsb pdb:4LRK|rcsb pdb:4O96|dip:DIP-60659N	refseq:NP_057490.2|ensembl:ENSG00000143222(gene)|ensembl:ENST00000368003(transcript)|go:"GO:0007420"(brain development)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0061657"(UFM1 conjugating enzyme activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071568"(UFM1 transferase activity)|go:"GO:0071569"(protein ufmylation)|go:"GO:1990592"(protein K69-linked ufmylation)|interpro:IPR014806(Protein of unknown function DUF1782)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2K07|rcsb pdb:2Z6O|rcsb pdb:2Z6P|rcsb pdb:3EVX|refseq:XP_016856939.1|refseq:XP_016856940.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:enXU0hiDHv8QGNYEh1mXmMzST+083334	rogid:qM6IH1SjQcAXszcGGqin8bLe4Pk9606	intact-crc:C1716570EA8130A4|rigid:qQhhjv5rf7/qgc8EsnuxZL2GdT4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61601	uniprotkb:Q7DB77	intact:EBI-749635|uniprotkb:P29554|uniprotkb:Q8IYC3|uniprotkb:Q9H0W2|ensembl:ENSP00000220931|ensembl:ENSP00000310587|ensembl:ENSP00000379256|ensembl:ENSP00000428105|ensembl:ENSP00000430476	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:ncald_human(display_long)|uniprotkb:NCALD(gene name)|psi-mi:NCALD(display_short)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039508|imex:IM-23549-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035714.1|refseq:NP_001035715.1|refseq:NP_001035716.1|refseq:NP_001035717.1|refseq:NP_001035718.1|refseq:NP_001035719.1|refseq:NP_001035720.1|refseq:NP_114430.2|refseq:XP_011515634.1|refseq:XP_011515635.1|refseq:XP_011515636.1|refseq:XP_011515637.1|refseq:XP_016869390.1|refseq:XP_016869391.1|ensembl:ENSG00000104490(gene)|ensembl:ENST00000220931(transcript)|ensembl:ENST00000311028(transcript)|ensembl:ENST00000395923(transcript)|ensembl:ENST00000519508(transcript)|ensembl:ENST00000521599(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0015631"(tubulin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043014"(alpha-tubulin binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P61601|reactome:R-HSA-451308	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:1/KBd+bN0cMZa81XKSSGPxgQEzc9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:9F098E95B9051B1B|rigid:NW9lpVQdfwALyaamEljTN/cqgoo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96Q11	uniprotkb:Q8XAL7	intact:EBI-2839106|uniprotkb:Q9Y362|uniprotkb:Q9BS97|uniprotkb:Q8ND57|uniprotkb:A8K2Z6|uniprotkb:B7WP13|uniprotkb:C9JKA2|ensembl:ENSP00000251607|ensembl:ENSP00000415100	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	psi-mi:trnt1_human(display_long)|uniprotkb:TRNT1(gene name)|psi-mi:TRNT1(display_short)|uniprotkb:Mitochondrial tRNA nucleotidyl transferase, CCA-adding(gene name synonym)|uniprotkb:mt CCA-adding enzyme(gene name synonym)|uniprotkb:mt tRNA CCA-diphosphorylase(gene name synonym)|uniprotkb:mt tRNA CCA-pyrophosphorylase(gene name synonym)|uniprotkb:mt tRNA adenylyltransferase(gene name synonym)|uniprotkb:CGI-47(orf name)	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039438|imex:IM-23549-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532078.1|refseq:XP_011532079.1|refseq:XP_011532080.1|ensembl:ENSG00000072756(gene)|ensembl:ENST00000251607(transcript)|ensembl:ENST00000434583(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001680"(tRNA 3'-terminal CCA addition)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016437"(tRNA cytidylyltransferase activity)|go:"GO:0034062"(5'-3' RNA polymerase activity)|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0052927"("CTP:tRNA cytidylyltransferase activity")|go:"GO:0052928"("CTP:3'-cytidine-tRNA cytidylyltransferase activity")|go:"GO:0052929"("ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002646(Polynucleotide adenylyltransferase region)|interpro:IPR032828|interpro:IPR043519|rcsb pdb:1OU5|rcsb pdb:4X4W|reactome:R-HSA-6785470|reactome:R-HSA-6784531|refseq:NP_001289875.1|refseq:NP_886552.2	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:COxi4PrWifNnDPkI+lile/5kD9I9606	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	intact-crc:F21A05A61B0056D6|rigid:2fkFc3ICDs1nvcYYs5P7hqnjtmI	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P55211	uniprotkb:Q8XAL7	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039290|imex:IM-23549-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	intact-crc:1C26FD092B9DE813|rigid:7k9kmTQrmSBvIMvcleDJFlJsRMU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAL7	uniprotkb:O43414	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-9679612|uniprotkb:B1AK98|uniprotkb:Q5T2T7|uniprotkb:Q5T2T9|uniprotkb:Q5TG35|uniprotkb:Q9BQA0|uniprotkb:Q9UEB4|ensembl:ENSP00000361331	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:eri3_human(display_long)|uniprotkb:ERI3(gene name)|psi-mi:ERI3(display_short)|uniprotkb:PINT1(gene name synonym)|uniprotkb:PRNPIP(gene name synonym)|uniprotkb:PRNPIP1(gene name synonym)|uniprotkb:Prion interactor 1(gene name synonym)|uniprotkb:Prion protein-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039429|imex:IM-23549-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_001288627.1|refseq:NP_001288628.1|refseq:NP_001288629.1|refseq:NP_001288630.1|ensembl:ENSP00000361331|ensembl:ENST00000372259|ensembl:ENSP00000361333|refseq:NP_076971.1|ensembl:ENSG00000117419(gene)|ensembl:ENST00000372257(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|mint:O43414|rcsb pdb:2XRI	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:Ke3BT8EH5uiVr+FunIbBBwvh/bM9606	intact-crc:ED5A74C88503D7F5|rigid:0ZVXKihI+3/vwEnITaIrN+fXQ4E	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96IZ6	uniprotkb:A0A0H3JGR6	intact:EBI-7211882|uniprotkb:A6NNC4|uniprotkb:Q9P0B5|uniprotkb:Q9H9G9|uniprotkb:Q9NUI8|intact:MINT-3054259|ensembl:ENSP00000309610	intact:EBI-10039274|ensemblbacteria:BAB34273|ensemblbacteria:QCH83944|uniprotkb:A0A7U8R338|uniprotkb:A0A6M0JIH9|uniprotkb:A0A6M7CAZ4	psi-mi:met2a_human(display_long)|uniprotkb:METTL2A(gene name)|psi-mi:METTL2A(display_short)|uniprotkb:METTL2(gene name synonym)|uniprotkb:Methyltransferase-like protein 2A(gene name synonym)|uniprotkb:HSPC266(orf name)	psi-mi:a0a0h3jgr6_eco57(display_long)|uniprotkb:E5F08_07770(orf name)|uniprotkb:nleD(gene name)|psi-mi:nleD(display_short)|uniprotkb:ECs_0850(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039258|imex:IM-23549-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_859076.3|ensembl:ENSG00000087995(gene)|ensembl:ENST00000311506(transcript)|go:"GO:0016427"("tRNA (cytosine) methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0052735"("tRNA (cytosine-3-)-methyltransferase activity")|interpro:IPR026113|interpro:IPR029063	uniprotkb:Q7AGE0(uniprot-removed-ac)|refseq:NP_308877.1|refseq:WP_001247925.1|interpro:IPR028208|ensemblbacteria:BAB34273(transcript)|ensemblbacteria:CAM50_0020160(gene)|ensemblbacteria:ECs_0850(gene)|ensemblbacteria:QCH83944(transcript)	-	comment:mint|function:Probable methyltransferase|comment:homomint	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:UDMjkoiVoFtAUI7N3PDqj5ELSFI9606	rogid:zkF+5p88ddmXoI6VON0GRkdetcU83334	intact-crc:4D46650461D4E14B|rigid:mLvQ55YwmTtroKvdTxrjyulJLrQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49759	uniprotkb:Q8XA11	intact:EBI-473775|uniprotkb:Q8N5V8|uniprotkb:Q0P694|intact:EBI-2622912|uniprotkb:B4DFW7|ensembl:ENSP00000326830	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:clk1_human(display_long)|uniprotkb:CDC-like kinase 1(gene name synonym)|uniprotkb:CLK1(gene name)|psi-mi:CLK1(display_short)|uniprotkb:CLK(gene name synonym)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038970|imex:IM-23549-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004062.2|refseq:NP_001155879.1|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49759|rcsb pdb:1Z57|rcsb pdb:2VAG|rcsb pdb:5J1V|rcsb pdb:5J1W|rcsb pdb:5X8I|rcsb pdb:6FT8|rcsb pdb:6FT9|rcsb pdb:6FYO|rcsb pdb:6G33|rcsb pdb:6I5H|rcsb pdb:6I5I|rcsb pdb:6I5K|rcsb pdb:6I5L|rcsb pdb:6KHD|rcsb pdb:6Q8K|rcsb pdb:6Q8P|rcsb pdb:6QTY|rcsb pdb:6R3D|rcsb pdb:6R6E|rcsb pdb:6R6X|rcsb pdb:6R8J|rcsb pdb:6RAA|rcsb pdb:6TW2|rcsb pdb:6YTA|rcsb pdb:6YTD|rcsb pdb:6YTE|rcsb pdb:6YTG|rcsb pdb:6YTI|rcsb pdb:6Z4Z|rcsb pdb:6Z50|rcsb pdb:6ZLN|rcsb pdb:7AK3|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENSG00000013441(gene)|ensembl:ENST00000321356(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HUyYLfLTfZHyTdtTNdbR/HPBloM9606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:B6CFA8B8DC7A9618|rigid:V+VYmyTEy8pcXOEJ4ODb1NiW6cY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96HQ2	uniprotkb:Q8XA11	intact:EBI-10038935|uniprotkb:Q8WVE3|ensembl:ENSP00000394183	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:c2ail_human(display_long)|uniprotkb:CDKN2AIPNL(gene name)|psi-mi:CDKN2AIPNL(display_short)|uniprotkb:CDKN2A-interacting protein N-terminal-like protein(gene name synonym)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038949|imex:IM-23549-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_542387.1|ensembl:ENSG00000237190(gene)|ensembl:ENST00000458198(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR021859|dip:DIP-61982N	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:D9Y5uROpQokbORFnDCrBSgHRTHc9606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:C1C97188CE571180|rigid:7/P51M3xeh+kbvOIp9l87t6D/nc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NPQ8	uniprotkb:Q8XB62	intact:EBI-717509|uniprotkb:Q0P508|uniprotkb:Q2T9J1|uniprotkb:Q7Z352|uniprotkb:Q96EZ1|uniprotkb:Q96SZ2|uniprotkb:Q9H064|uniprotkb:Q9H5H3|uniprotkb:Q9H9E7|ensembl:ENSP00000432008	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	psi-mi:ric8a_human(display_long)|uniprotkb:Protein Ric-8A(gene name synonym)|uniprotkb:RIC8A(gene name)|psi-mi:RIC8A(display_short)	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038846|imex:IM-23549-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273063.1|refseq:NP_068751.4|refseq:XP_016873596.1|ensembl:ENSG00000177963(gene)|ensembl:ENST00000526104(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0070586"(cell-cell adhesion involved in gastrulation)|go:"GO:0071711"(basement membrane organization)|interpro:IPR008376(Synembryn)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019318|mint:Q9NPQ8|go:"GO:0001965"(G-protein alpha-subunit binding)	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:jNCxRLnDY2aSw6SMtE82Tny1IE89606	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	intact-crc:1A1745D73140071E|rigid:G9MzjwIAron9qJW3oXc71+l1qos	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H3R5	uniprotkb:Q8XB62	intact:EBI-1003700|uniprotkb:A8K3Y1|ensembl:ENSP00000283006	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	psi-mi:cenph_human(display_long)|uniprotkb:Interphase centromere complex protein 35(gene name synonym)|uniprotkb:ICEN35(gene name synonym)|uniprotkb:CENPH(gene name)|psi-mi:CENPH(display_short)	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038796|imex:IM-23549-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075060.1|ensembl:ENSG00000153044(gene)|ensembl:ENST00000283006(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0051383"(kinetochore organization)|interpro:IPR040034|mint:Q9H3R5|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025|interpro:IPR008426(Centromere H)	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:NcnQtHH8NhQ2AUePTPR3TRrpqaI9606	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	intact-crc:9219AD1CD76EA545|rigid:E2ee4xRBiu3oDMgP8APRWAyxul4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB50	uniprotkb:Q13287	intact:EBI-6379656|ensemblbacteria:BAB38013|uniprotkb:Q7A9M3|uniprotkb:A0A6M0JN46	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:q7db50_eco57(display_long)|uniprotkb:espG(gene name)|psi-mi:espG(display_short)|uniprotkb:ECs_4590(orf name)|uniprotkb:E5F08_27545(orf name)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038746|imex:IM-23549-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_312617.1|ensemblbacteria:BAB38013(transcript)|ensemblbacteria:ECs_4590(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|interpro:IPR009669(EspG)|rcsb pdb:3PCR|rcsb pdb:3PCS|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|refseq:WP_001301460.1|interpro:IPR043098	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/10/11	rogid:g7FQ+G0CKEqSrzN+2H+OAnLu7No83334	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	intact-crc:F2A465ECBF2FE584|rigid:ECozAgrWsBgj/lxMRGMTozaWyr8	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7DB85	uniprotkb:Q9Y5X1	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038742|imex:IM-23549-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	intact-crc:51ABE3A5BC5FA2F2|rigid:GREPzuN+sA6TGjAc6ClCQYolaIk	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XA11	uniprotkb:P62191	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039018|imex:IM-23549-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606	intact-crc:6BD47E9BCDD8121B|rigid:BQnzh2juILO/0YE9dI5RQvjokTc	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XAL7	uniprotkb:P61968	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-2798728|uniprotkb:O00158|uniprotkb:O88894|uniprotkb:D3DT23|ensembl:ENSP00000359573|ensembl:ENSP00000359575	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:lmo4_human(display_long)|uniprotkb:Breast tumor autoantigen(gene name synonym)|uniprotkb:LIM domain only protein 4(gene name synonym)|uniprotkb:LMO4(gene name)|psi-mi:LMO4(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039433|imex:IM-23549-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_006760.1|refseq:XP_005271348.1|ensembl:ENSG00000143013(gene)|ensembl:ENST00000370542(transcript)|ensembl:ENST00000370544(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021514"(ventral spinal cord interneuron differentiation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR001781(Zinc finger, LIM-type)|mint:P61968|go:"GO:0050865"(regulation of cell activation)|rcsb pdb:2L4Z|dip:DIP-41414N	-	-	crc64:C8AC295144AD7787	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:A6F+R5tMkoNqN0nAuwTjOoVnjQE9606	intact-crc:EC9E231471E64BE8|rigid:j6OcLTceI60gI9OtnstDrWiBRvw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P00374	uniprotkb:Q8XAL7	intact:EBI-10039315|ensembl:ENSP00000396308|ensembl:ENSP00000426474|uniprotkb:B4DDD2|uniprotkb:Q14130|uniprotkb:Q6IRW8	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	psi-mi:dyr_human(display_long)|uniprotkb:DHFR(gene name)|psi-mi:DHFR(display_short)	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039425|imex:IM-23549-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000782.1|refseq:NP_001277283.1|ensembl:ENST00000439211(transcript)|ensembl:ENST00000505337(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031427"(response to methotrexate)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051870"(methotrexate binding)|rcsb pdb:4QHV|rcsb pdb:4QJC|rcsb pdb:5HPB|rcsb pdb:5HQY|rcsb pdb:5HQZ|rcsb pdb:5HSR|rcsb pdb:5HSU|rcsb pdb:5HT4|rcsb pdb:5HT5|rcsb pdb:5HUI|rcsb pdb:5HVB|rcsb pdb:5HVE|rcsb pdb:6A7C|rcsb pdb:6A7E|rcsb pdb:6DAV|rcsb pdb:6DE4|rcsb pdb:6VCJ|rcsb pdb:7ESE|reactome:R-HSA-1474151|reactome:R-HSA-196757|reactome:R-HSA-69205|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:0070402"(NADPH binding)|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase)|interpro:IPR017925|interpro:IPR024072|rcsb pdb:1BOZ|rcsb pdb:1DHF|rcsb pdb:1DLR|rcsb pdb:1DLS|rcsb pdb:1DRF|rcsb pdb:1HFP|rcsb pdb:1HFQ|rcsb pdb:1HFR|rcsb pdb:1KMS|rcsb pdb:1KMV|rcsb pdb:1MVS|rcsb pdb:1MVT|rcsb pdb:1OHJ|rcsb pdb:1OHK|rcsb pdb:1PD8|rcsb pdb:1PD9|rcsb pdb:1PDB|rcsb pdb:1S3U|rcsb pdb:1S3V|rcsb pdb:1S3W|rcsb pdb:1U71|rcsb pdb:1U72|rcsb pdb:1YHO|rcsb pdb:2C2S|rcsb pdb:2C2T|rcsb pdb:2DHF|rcsb pdb:2W3A|rcsb pdb:2W3B|rcsb pdb:2W3M|rcsb pdb:3EIG|rcsb pdb:3F8Y|rcsb pdb:3F8Z|rcsb pdb:3F91|rcsb pdb:3FS6|rcsb pdb:3GHC|rcsb pdb:3GHV|rcsb pdb:3GHW|ensembl:ENSG00000228716(gene)|rcsb pdb:3GI2|rcsb pdb:3GYF|rcsb pdb:3L3R|rcsb pdb:3N0H|rcsb pdb:3NTZ|rcsb pdb:3NU0|rcsb pdb:3NXO|rcsb pdb:3NXR|rcsb pdb:3NXT|rcsb pdb:3NXV|rcsb pdb:3NXX|rcsb pdb:3NXY|rcsb pdb:3NZD|rcsb pdb:3OAF|rcsb pdb:3S3V|rcsb pdb:3S7A|rcsb pdb:4DDR|rcsb pdb:4G95|rcsb pdb:4KAK|rcsb pdb:4KBN|rcsb pdb:4KD7|rcsb pdb:4KEB|rcsb pdb:4KFJ|rcsb pdb:4M6J|rcsb pdb:4M6K|rcsb pdb:4M6L	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:4yoitO/ETpazAN2OtD/rXCte4289606	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	intact-crc:E257362AC611DF50|rigid:BwRxu/G90K7THotPE+clPdJgMdQ	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UHR4	uniprotkb:Q7DB77	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039484|imex:IM-23549-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:88F96522E1D9F631|rigid:VE0c/Qjb0IzvfXI7VcEea+480MY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49407	uniprotkb:Q7DB77	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039479|imex:IM-23549-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:CDF5DB400827E2A9|rigid:egVpT0wXvb3+UoIaPOCReuZ+1zM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8XB62	uniprotkb:Q8IY31	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	intact:EBI-744203|uniprotkb:Q5GLZ2|uniprotkb:Q9BUG5|intact:EBI-2561300|uniprotkb:J3QL09|ensembl:ENSP00000378809|ensembl:ENSP00000463138	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:ift20_human(display_long)|uniprotkb:IFT20(gene name)|psi-mi:IFT20(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038810|imex:IM-23549-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	refseq:NP_001254706.1|refseq:NP_001254707.1|refseq:NP_777547.1|refseq:NP_001254703.1|refseq:NP_001254704.1|refseq:NP_001254705.1|ensembl:ENSG00000109083(gene)|ensembl:ENST00000395418(transcript)|ensembl:ENST00000585313(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001822"(kidney development)|go:"GO:0002046"(opsin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005902"(microvillus)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008542"(visual learning)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036372"(opsin transport)|go:"GO:0042073"(intraciliary transport)|go:"GO:0044292"(dendrite terminus)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0051642"(centrosome localization)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060271"(cilium assembly)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090102"(cochlea development)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1902636"(kinociliary basal body)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR028172|reactome:R-HSA-5620924	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	rogid:/sGgagcq0b/YoxjD4Psc7D6jY2Q9606	intact-crc:498E4A19F0F7901C|rigid:GOx3vrhYE3HmDkzvD5qrQmzRvCU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UI95	uniprotkb:Q7DB85	intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym)	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10038698|imex:IM-23549-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:KBeawMhcP3iXUel74pUDl85A/vw9606	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	intact-crc:F930AC0880CE4B55|rigid:mo1NSwnqmsBgvMW9SA+QggPUKSg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P19388	uniprotkb:Q8XBX8	intact:EBI-395189|uniprotkb:O43380|uniprotkb:Q6PIH5|uniprotkb:Q9BT06|uniprotkb:B2R6L4|uniprotkb:D6W5Y1|ensembl:ENSP00000464739|ensembl:ENSP00000478303|ensembl:ENSP00000485021	intact:EBI-10039153|uniprotkb:Q7AAV0|ensemblbacteria:BAB37280|ensemblbacteria:QCH81151|uniprotkb:A0A0H3JHS6|uniprotkb:A0A6M0JF43	psi-mi:rpab1_human(display_long)|uniprotkb:POLR2E(gene name)|psi-mi:POLR2E(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit E(gene name synonym)|uniprotkb:RPB5 homolog(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 23 kDa polypeptide(gene name synonym)|uniprotkb:XAP4(gene name synonym)	psi-mi:nleb1_eco57(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:ECs_3857(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039185|imex:IM-23549-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002686.2|ensembl:ENSG00000099817(gene)|ensembl:ENST00000586746(transcript)|ensembl:ENST00000612655(transcript)|ensembl:ENST00000615234(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR000783(RNA polymerase, subunit H/Rpb5 C-terminal)|interpro:IPR005571(RNA polymerase, Rpb5, N-terminal)|interpro:IPR014381(DNA-directed RNA polymerase, RPB5 subunit)|interpro:IPR020608|interpro:IPR020609|interpro:IPR035913|interpro:IPR036710|interpro:IPR039531|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|mint:P19388|rcsb pdb:5IY6|rcsb pdb:5IY7|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-167246|dip:DIP-56N	refseq:NP_311884.1|refseq:WP_000953022.1|ensemblbacteria:BAB37280(transcript)|ensemblbacteria:CAM50_0004305(gene)|ensemblbacteria:ECs_3857(gene)|ensemblbacteria:QCH81151(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:BIVesx7KODhdpcgjhU6CghhXNQE9606	rogid:s08ivrjNoMdHHNcIwH+V7ZobNOQ83334	intact-crc:EBE41F30F59F1CA3|rigid:EGGLTS8gvnQ9KWaTXgG0OZXT9ZM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UQB8	uniprotkb:B7UM99	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	intact:EBI-2504426|ensemblbacteria:CAS11489|uniprotkb:O50190|uniprotkb:O52147	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:tir_eco27(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:espE(gene name synonym)|uniprotkb:E2348C_3941(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040348|imex:IM-23549-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	ensemblbacteria:CAS11489(transcript)|ensemblbacteria:E2348C_3941(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR022638|interpro:IPR022639|interpro:IPR037003|rcsb pdb:2CI9|rcsb pdb:2CIA|refseq:WP_001339882.1|dip:DIP-27648N|dip:DIP-55921N|mint:B7UM99	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	rogid:KzZZf57ln3nXEZ0Rpn9Tf/B1DCk574521	intact-crc:D487D7872AB8F6F3|rigid:ydlpfoKg2JP+g7zpvmz7rFp8Hww	false	-	sufficient binding region:338-550(IPR022639)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UI95	uniprotkb:Q7DB85	intact:EBI-77889|ensembl:ENSP00000235310|ensembl:ENSP00000365855|ensembl:ENSP00000365882|uniprotkb:Q5TGW7|uniprotkb:Q9UNA7|uniprotkb:Q9Y6I6|uniprotkb:B3KNE3	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	psi-mi:md2l2_human(display_long)|uniprotkb:MAD2L2(gene name)|psi-mi:MAD2L2(display_short)|uniprotkb:MAD2B(gene name synonym)|uniprotkb:REV7(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 2(gene name synonym)|uniprotkb:REV7 homolog(gene name synonym)	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040201|imex:IM-23549-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000116670(gene)|ensembl:ENST00000235310(transcript)|ensembl:ENST00000376667(transcript)|ensembl:ENST00000376692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007015"(actin filament organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016035"(zeta DNA polymerase complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042772"(DNA damage response, signal transduction resulting in transcription)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|rcsb pdb:3ABD|rcsb pdb:3ABE|rcsb pdb:3VU7|rcsb pdb:4EXT|rcsb pdb:4GK0|rcsb pdb:4GK5|rcsb pdb:5XPT|rcsb pdb:5XPU|rcsb pdb:6BC8|rcsb pdb:6BCD|rcsb pdb:6BI7|rcsb pdb:6K07|rcsb pdb:6K08|rcsb pdb:6KEA|rcsb pdb:6KTO|rcsb pdb:6M7A|rcsb pdb:6M7B|rcsb pdb:6NIF|rcsb pdb:6VE5|rcsb pdb:6WS0|rcsb pdb:6WS5|rcsb pdb:6WW9|rcsb pdb:6WWA|rcsb pdb:7L9P|reactome:R-HSA-110312|reactome:R-HSA-5655862|reactome:R-HSA-5656121|refseq:NP_001120797.1|refseq:NP_006332.3|refseq:XP_011538809.1	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:KBeawMhcP3iXUel74pUDl85A/vw9606	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	intact-crc:7452C30D41CCB245|rigid:mo1NSwnqmsBgvMW9SA+QggPUKSg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WV41	uniprotkb:Q7DB85	intact:EBI-2481535|ensembl:ENSP00000311427|uniprotkb:B1NM17	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	psi-mi:snx33_human(display_long)|uniprotkb:SNX33(gene name)|psi-mi:SNX33(display_short)|uniprotkb:SH3PX3(gene name synonym)|uniprotkb:SH3PXD3C(gene name synonym)|uniprotkb:SNX30(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3(gene name synonym)	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040205|imex:IM-23549-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173548(gene)|ensembl:ENST00000308527(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0016020"(membrane)|go:"GO:0017038"(protein import)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028642|interpro:IPR036028|interpro:IPR036871|interpro:IPR037427|mint:Q8WV41|rcsb pdb:4AKV|go:"GO:0016197"(endosomal transport)|refseq:NP_695003.1|refseq:NP_001305075.1	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:rhvspe+J40o9M1MJtpUIyeQFLRs9606	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	intact-crc:8D289119093DAFA3|rigid:EJWElMHIfoLZPiYqkhIBXyoQTjI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HQ2	uniprotkb:Q8XA11	intact:EBI-10038935|uniprotkb:Q8WVE3|ensembl:ENSP00000394183	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:c2ail_human(display_long)|uniprotkb:CDKN2AIPNL(gene name)|psi-mi:CDKN2AIPNL(display_short)|uniprotkb:CDKN2A-interacting protein N-terminal-like protein(gene name synonym)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040287|imex:IM-23549-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_542387.1|ensembl:ENSG00000237190(gene)|ensembl:ENST00000458198(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR021859|dip:DIP-61982N	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:D9Y5uROpQokbORFnDCrBSgHRTHc9606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:530796DB815A1159|rigid:7/P51M3xeh+kbvOIp9l87t6D/nc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XA11	uniprotkb:Q9NWS0	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040278|imex:IM-23549-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606	intact-crc:5A2CAE9C4DBC9AB8|rigid:BOQdiS8j1wlzSuTh62U6lJGzrzo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XA11	uniprotkb:O43257	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-347522|uniprotkb:Q6IB12|ensembl:ENSP00000304593	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:znhi1_human(display_long)|uniprotkb:Cyclin-G1-binding protein 1(gene name synonym)|uniprotkb:Zinc finger protein subfamily 4A member 1(gene name synonym)|uniprotkb:p18 Hamlet(gene name synonym)|uniprotkb:ZNHIT1(gene name)|psi-mi:ZNHIT1(display_short)|uniprotkb:CGBP1(gene name synonym)|uniprotkb:ZNFN4A1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040272|imex:IM-23549-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_006340.1|ensembl:ENSG00000106400(gene)|ensembl:ENST00000305105(transcript)|go:"GO:0000812"(Swr1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031491"(nucleosome binding)|go:"GO:0043486"(histone exchange)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039723|mint:O43257	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:Q7J5KSTTPql/B3mtDg1xvX0EWjw9606	intact-crc:8F9B973B48035AA8|rigid:ZKzZi/Z6g5p/LPvOaXKz67zdspg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XA11	uniprotkb:P49759	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-473775|uniprotkb:Q8N5V8|uniprotkb:Q0P694|intact:EBI-2622912|uniprotkb:B4DFW7|ensembl:ENSP00000326830	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:clk1_human(display_long)|uniprotkb:CDC-like kinase 1(gene name synonym)|uniprotkb:CLK1(gene name)|psi-mi:CLK1(display_short)|uniprotkb:CLK(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040284|imex:IM-23549-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_004062.2|refseq:NP_001155879.1|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49759|rcsb pdb:1Z57|rcsb pdb:2VAG|rcsb pdb:5J1V|rcsb pdb:5J1W|rcsb pdb:5X8I|rcsb pdb:6FT8|rcsb pdb:6FT9|rcsb pdb:6FYO|rcsb pdb:6G33|rcsb pdb:6I5H|rcsb pdb:6I5I|rcsb pdb:6I5K|rcsb pdb:6I5L|rcsb pdb:6KHD|rcsb pdb:6Q8K|rcsb pdb:6Q8P|rcsb pdb:6QTY|rcsb pdb:6R3D|rcsb pdb:6R6E|rcsb pdb:6R6X|rcsb pdb:6R8J|rcsb pdb:6RAA|rcsb pdb:6TW2|rcsb pdb:6YTA|rcsb pdb:6YTD|rcsb pdb:6YTE|rcsb pdb:6YTG|rcsb pdb:6YTI|rcsb pdb:6Z4Z|rcsb pdb:6Z50|rcsb pdb:6ZLN|rcsb pdb:7AK3|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENSG00000013441(gene)|ensembl:ENST00000321356(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:HUyYLfLTfZHyTdtTNdbR/HPBloM9606	intact-crc:79AFEFA40007CE73|rigid:V+VYmyTEy8pcXOEJ4ODb1NiW6cY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAL7	uniprotkb:P61968	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-2798728|uniprotkb:O00158|uniprotkb:O88894|uniprotkb:D3DT23|ensembl:ENSP00000359573|ensembl:ENSP00000359575	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:lmo4_human(display_long)|uniprotkb:Breast tumor autoantigen(gene name synonym)|uniprotkb:LIM domain only protein 4(gene name synonym)|uniprotkb:LMO4(gene name)|psi-mi:LMO4(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040261|imex:IM-23549-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_006760.1|refseq:XP_005271348.1|ensembl:ENSG00000143013(gene)|ensembl:ENST00000370542(transcript)|ensembl:ENST00000370544(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021514"(ventral spinal cord interneuron differentiation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR001781(Zinc finger, LIM-type)|mint:P61968|go:"GO:0050865"(regulation of cell activation)|rcsb pdb:2L4Z|dip:DIP-41414N	-	-	crc64:C8AC295144AD7787	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:A6F+R5tMkoNqN0nAuwTjOoVnjQE9606	intact-crc:4E60ACFE73756A3B|rigid:j6OcLTceI60gI9OtnstDrWiBRvw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05204	uniprotkb:Q8XAL7	intact:EBI-1758689|uniprotkb:Q0VGD5|uniprotkb:Q6FGI5|uniprotkb:Q96C64|ensembl:ENSP00000355228|ensembl:ENSP00000481160	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	psi-mi:hmgn2_human(display_long)|uniprotkb:HMGN2(gene name)|psi-mi:HMGN2(display_short)|uniprotkb:HMG17(gene name synonym)|uniprotkb:High mobility group nucleosome-binding domain-containing protein 2(gene name synonym)	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040268|imex:IM-23549-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005508.1|ensembl:ENSG00000198830(gene)|ensembl:ENST00000361427(transcript)|ensembl:ENST00000619352(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR000079(High mobility group protein HMG14 and HMG17)|mint:P05204	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:j8Khsp7BUJh0L9SicpVNR8LP6ZU9606	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	intact-crc:FD6EB8233918C4E2|rigid:PF/SuX8AHZOi79VBEk4FrlTd2hE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAL7	uniprotkb:P55211	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040252|imex:IM-23549-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	intact-crc:7AAD361722033384|rigid:7k9kmTQrmSBvIMvcleDJFlJsRMU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19388	uniprotkb:Q8XBX8	intact:EBI-395189|uniprotkb:O43380|uniprotkb:Q6PIH5|uniprotkb:Q9BT06|uniprotkb:B2R6L4|uniprotkb:D6W5Y1|ensembl:ENSP00000464739|ensembl:ENSP00000478303|ensembl:ENSP00000485021	intact:EBI-10039153|uniprotkb:Q7AAV0|ensemblbacteria:BAB37280|ensemblbacteria:QCH81151|uniprotkb:A0A0H3JHS6|uniprotkb:A0A6M0JF43	psi-mi:rpab1_human(display_long)|uniprotkb:POLR2E(gene name)|psi-mi:POLR2E(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit E(gene name synonym)|uniprotkb:RPB5 homolog(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 23 kDa polypeptide(gene name synonym)|uniprotkb:XAP4(gene name synonym)	psi-mi:nleb1_eco57(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:ECs_3857(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040243|imex:IM-23549-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002686.2|ensembl:ENSG00000099817(gene)|ensembl:ENST00000586746(transcript)|ensembl:ENST00000612655(transcript)|ensembl:ENST00000615234(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR000783(RNA polymerase, subunit H/Rpb5 C-terminal)|interpro:IPR005571(RNA polymerase, Rpb5, N-terminal)|interpro:IPR014381(DNA-directed RNA polymerase, RPB5 subunit)|interpro:IPR020608|interpro:IPR020609|interpro:IPR035913|interpro:IPR036710|interpro:IPR039531|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|mint:P19388|rcsb pdb:5IY6|rcsb pdb:5IY7|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-167246|dip:DIP-56N	refseq:NP_311884.1|refseq:WP_000953022.1|ensemblbacteria:BAB37280(transcript)|ensemblbacteria:CAM50_0004305(gene)|ensemblbacteria:ECs_3857(gene)|ensemblbacteria:QCH81151(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:BIVesx7KODhdpcgjhU6CghhXNQE9606	rogid:s08ivrjNoMdHHNcIwH+V7ZobNOQ83334	intact-crc:685014E45D55E96C|rigid:EGGLTS8gvnQ9KWaTXgG0OZXT9ZM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00374	uniprotkb:Q8XAL7	intact:EBI-10039315|ensembl:ENSP00000396308|ensembl:ENSP00000426474|uniprotkb:B4DDD2|uniprotkb:Q14130|uniprotkb:Q6IRW8	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	psi-mi:dyr_human(display_long)|uniprotkb:DHFR(gene name)|psi-mi:DHFR(display_short)	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040255|imex:IM-23549-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000782.1|refseq:NP_001277283.1|ensembl:ENST00000439211(transcript)|ensembl:ENST00000505337(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031103"(axon regeneration)|go:"GO:0031427"(response to methotrexate)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051870"(methotrexate binding)|rcsb pdb:4QHV|rcsb pdb:4QJC|rcsb pdb:5HPB|rcsb pdb:5HQY|rcsb pdb:5HQZ|rcsb pdb:5HSR|rcsb pdb:5HSU|rcsb pdb:5HT4|rcsb pdb:5HT5|rcsb pdb:5HUI|rcsb pdb:5HVB|rcsb pdb:5HVE|rcsb pdb:6A7C|rcsb pdb:6A7E|rcsb pdb:6DAV|rcsb pdb:6DE4|rcsb pdb:6VCJ|rcsb pdb:7ESE|reactome:R-HSA-1474151|reactome:R-HSA-196757|reactome:R-HSA-69205|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:0070402"(NADPH binding)|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase)|interpro:IPR017925|interpro:IPR024072|rcsb pdb:1BOZ|rcsb pdb:1DHF|rcsb pdb:1DLR|rcsb pdb:1DLS|rcsb pdb:1DRF|rcsb pdb:1HFP|rcsb pdb:1HFQ|rcsb pdb:1HFR|rcsb pdb:1KMS|rcsb pdb:1KMV|rcsb pdb:1MVS|rcsb pdb:1MVT|rcsb pdb:1OHJ|rcsb pdb:1OHK|rcsb pdb:1PD8|rcsb pdb:1PD9|rcsb pdb:1PDB|rcsb pdb:1S3U|rcsb pdb:1S3V|rcsb pdb:1S3W|rcsb pdb:1U71|rcsb pdb:1U72|rcsb pdb:1YHO|rcsb pdb:2C2S|rcsb pdb:2C2T|rcsb pdb:2DHF|rcsb pdb:2W3A|rcsb pdb:2W3B|rcsb pdb:2W3M|rcsb pdb:3EIG|rcsb pdb:3F8Y|rcsb pdb:3F8Z|rcsb pdb:3F91|rcsb pdb:3FS6|rcsb pdb:3GHC|rcsb pdb:3GHV|rcsb pdb:3GHW|ensembl:ENSG00000228716(gene)|rcsb pdb:3GI2|rcsb pdb:3GYF|rcsb pdb:3L3R|rcsb pdb:3N0H|rcsb pdb:3NTZ|rcsb pdb:3NU0|rcsb pdb:3NXO|rcsb pdb:3NXR|rcsb pdb:3NXT|rcsb pdb:3NXV|rcsb pdb:3NXX|rcsb pdb:3NXY|rcsb pdb:3NZD|rcsb pdb:3OAF|rcsb pdb:3S3V|rcsb pdb:3S7A|rcsb pdb:4DDR|rcsb pdb:4G95|rcsb pdb:4KAK|rcsb pdb:4KBN|rcsb pdb:4KD7|rcsb pdb:4KEB|rcsb pdb:4KFJ|rcsb pdb:4M6J|rcsb pdb:4M6K|rcsb pdb:4M6L	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:4yoitO/ETpazAN2OtD/rXCte4289606	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	intact-crc:84BE701578B75C24|rigid:BwRxu/G90K7THotPE+clPdJgMdQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAJ5	uniprotkb:P01210	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	intact:EBI-6656032|ensembl:ENSP00000324248|ensembl:ENSP00000400894|uniprotkb:B2RC23|uniprotkb:Q6FHC6|uniprotkb:Q6FHE6	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:penk_human(display_long)|uniprotkb:PENK(gene name)|psi-mi:PENK(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040235|imex:IM-23549-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	ensembl:ENSG00000181195(gene)|ensembl:ENST00000314922(transcript)|ensembl:ENST00000451791(transcript)|go:"GO:0001515"(opioid peptide activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0002118"(aggressive behavior)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007600"(sensory perception)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034466"(chromaffin granule lumen)|go:"GO:0034592"(synaptic vesicle lumen)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043679"(axon terminus)|go:"GO:0045471"(response to ethanol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051867"(general adaptation syndrome, behavioral process)|go:"GO:0070852"(cell body fiber)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071871"(response to epinephrine)|go:"GO:0031628"(opioid receptor binding)|go:"GO:0099013"(neuronal dense core vesicle lumen)|go:"GO:0099538"(synaptic signaling via neuropeptide)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000703(Proenkephalin A)|interpro:IPR006024(Opioid neuropeptide precursor)|rcsb pdb:1PLW|rcsb pdb:1PLX|rcsb pdb:2LWC|rcsb pdb:5E33|rcsb pdb:5E3A|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0098586"(cellular response to virus)|refseq:NP_001129162.1	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	rogid:xL8ujOb7RFDy5+t+Oe/ph/XOoOM9606	intact-crc:408597329FBD25DA|rigid:KpaHhap6NOsiixUq12D75qNbINA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7DB76	uniprotkb:Q8TCX5	intact:EBI-10039068|uniprotkb:Q7A9Q0|ensemblbacteria:BAB37985|uniprotkb:A0A0H3JJD5|uniprotkb:A0A6M0JL37	intact:EBI-746325|uniprotkb:Q8TAV1|uniprotkb:Q96PV9|ensembl:ENSP00000289013|intact:EBI-12011872	psi-mi:q7db76_eco57(display_long)|uniprotkb:E5F08_27410(orf name)|uniprotkb:map(gene name)|psi-mi:map(display_short)|uniprotkb:ECs_4562(orf name)	psi-mi:rhpn1_human(display_long)|uniprotkb:KIAA1929(gene name synonym)|uniprotkb:GTP-Rho-binding protein 1(gene name synonym)|uniprotkb:RHPN1(gene name)|psi-mi:RHPN1(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040226|imex:IM-23549-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004959(IpaB/EvcA)|refseq:NP_312589.1|refseq:WP_000492638.1|ensemblbacteria:BAB37985(transcript)|ensemblbacteria:ECs_4562(gene)	interpro:IPR036274|interpro:IPR042715|reactome:R-HSA-5666185|reactome:R-HSA-8980692|ensembl:ENSG00000158106(gene)|ensembl:ENST00000289013(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004328(BRO1)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR036034|refseq:NP_443156.2	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/09/18	rogid:xO5ymWP2ug1VLyxelIaeen+24gM83334	rogid:EF1IVH0DLg/1KL4iWFVBktsl5589606	intact-crc:9D0C75BE3FAA043A|rigid:0Yiwj0imHykFHVs92LsiUMA6cao	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAJ5	uniprotkb:A2A2Y4	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	intact:EBI-6911547|uniprotkb:Q8N9L2|uniprotkb:Q53EP2|uniprotkb:Q5JV59|uniprotkb:A8MQB0|uniprotkb:B4DN14|uniprotkb:Q8IZ44|uniprotkb:Q5VZA1|uniprotkb:Q8N3Y5|uniprotkb:Q86WP8|ensembl:ENSP00000303508	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:frmd3_human(display_long)|uniprotkb:Band 4.1-like protein 4O(gene name synonym)|uniprotkb:EPB41L4O(gene name synonym)|uniprotkb:Ovary type protein 4.1(gene name synonym)|uniprotkb:FRMD3(gene name)|psi-mi:FRMD3(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040232|imex:IM-23549-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	refseq:NP_001231888.1|refseq:NP_001231889.1|refseq:NP_001231890.1|refseq:NP_001231891.1|refseq:NP_777598.3|ensembl:ENST00000304195(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031032"(actomyosin structure organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|ensembl:ENSG00000172159(gene)|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	rogid:mhyjQ1Yy8dmn8JseI7ehX//yySw9606	intact-crc:B358A177884626C8|rigid:kms1NOgh7ZGGd3jJyLXtwhDJQr0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y5X1	uniprotkb:Q7DB85	intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20	intact:EBI-10038700|uniprotkb:Q7A9R0|ensemblbacteria:BAB37973|ensemblbacteria:QCH80458|uniprotkb:A0A0H3JQD8	psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym)	psi-mi:q7db85_eco57(display_long)|uniprotkb:E5F08_27350(orf name)|uniprotkb:espF(gene name)|psi-mi:espF(display_short)|uniprotkb:ECs_4550(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040209|imex:IM-23549-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N	interpro:IPR006891(EspF protein)|refseq:WP_000931693.1|refseq:NP_312577.1|ensemblbacteria:BAB37973(transcript)|ensemblbacteria:CAM50_0000465(gene)|ensemblbacteria:ECs_4550(gene)|ensemblbacteria:QCH80458(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606	rogid:Xi+lGjtCtERpBpNdPvEPyVtkQlA83334	intact-crc:332D88BFF55DAF68|rigid:GREPzuN+sA6TGjAc6ClCQYolaIk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43924	uniprotkb:Q7DB77	intact:EBI-712685|uniprotkb:O43250|ensembl:ENSP00000287600	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:pde6d_human(display_long)|uniprotkb:Protein p17(gene name synonym)|uniprotkb:PDE6D(gene name)|psi-mi:PDE6D(display_short)|uniprotkb:PDED(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040019|imex:IM-23549-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277947.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050896"(response to stimulus)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017287(Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit)|interpro:IPR037036|mint:O43924|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:3T5G|rcsb pdb:3T5I|rcsb pdb:4JHP|rcsb pdb:4JV6|rcsb pdb:4JV8|rcsb pdb:4JVB|rcsb pdb:4JVF|rcsb pdb:5E80|rcsb pdb:5E8F|rcsb pdb:5F2U|rcsb pdb:5ML2|rcsb pdb:5ML3|rcsb pdb:5ML4|rcsb pdb:5ML6|rcsb pdb:5ML8|rcsb pdb:5NAL|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5X72|rcsb pdb:5X73|rcsb pdb:5X74|rcsb pdb:5YAV|rcsb pdb:5YAW|reactome:R-HSA-5624958|ensembl:ENSG00000156973(gene)|ensembl:ENST00000287600(transcript)|go:"GO:0005095"(GTPase inhibitor activity)|reactome:R-HSA-9648002|refseq:NP_002592.1|dip:DIP-36660N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5B|comment:Interaction appears to be very weak.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:dfEOckvNZPhkWSeQnKr4ugEdEmM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:FF765ABD7A4FE287|rigid:nSx3EzGVFU/94uLHaqDzzak+8G8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UM19	uniprotkb:Q7DB77	intact:EBI-744820|uniprotkb:Q5TG97|uniprotkb:Q8N611|uniprotkb:B2R5U2|uniprotkb:D3DPU1|ensembl:ENSP00000361935|ensembl:ENSP00000481834	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:hpcl4_human(display_long)|uniprotkb:HPCAL4(gene name)|psi-mi:HPCAL4(display_short)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040006|imex:IM-23549-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057341.1|ensembl:ENSG00000116983(gene)|ensembl:ENST00000617690(transcript)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR029534|ensembl:ENST00000372844(transcript)|refseq:NP_001269325.1|refseq:XP_016856936.1	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:+2KFQ7WO9Kyn14ySKaEmm1V6pRM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:A62B3C1CDB5877DE|rigid:1IogbQyoEvXFZXTvTXzoGXPvL0A	false	-	sufficient binding region:1-270(IPR022633)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7DB77	uniprotkb:P37235	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-749311|uniprotkb:Q969S5|ensembl:ENSP00000310749|ensembl:ENSP00000371184|ensembl:ENSP00000478231|ensembl:ENSP00000482993|ensembl:ENSP00000483786	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:hpcl1_human(display_long)|uniprotkb:Visinin-like protein 3(gene name synonym)|uniprotkb:Calcium-binding protein BDR-1(gene name synonym)|uniprotkb:HLP2(gene name synonym)|uniprotkb:HPCAL1(gene name)|psi-mi:HPCAL1(display_short)|uniprotkb:BDR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039998|imex:IM-23549-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_002140.2|refseq:NP_602293.1|refseq:XP_011508648.1|refseq:XP_011508649.1|refseq:XP_011508650.1|refseq:NP_001245286.1|refseq:NP_001245287.1|refseq:NP_001245288.1|refseq:XP_005246217.1|refseq:XP_005246218.1|refseq:XP_005246219.1|refseq:XP_005246220.1|refseq:XP_016859439.1|refseq:XP_016859440.1|refseq:XP_016859441.1|refseq:XP_016859442.1|ensembl:ENSG00000115756(gene)|ensembl:ENST00000307845(transcript)|ensembl:ENST00000381765(transcript)|ensembl:ENST00000613496(transcript)|ensembl:ENST00000620771(transcript)|ensembl:ENST00000622018(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|rcsb pdb:5T7C	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:oK04sIDCtghEOWIBNQ75bR34+2o9606	intact-crc:C0EFA41857950B44|rigid:1cwDS9Ro06Jrm9ll7Abp4YUxFYM	false	sufficient binding region:1-270(IPR022633)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B7UM99	uniprotkb:P37235	intact:EBI-2504426|ensemblbacteria:CAS11489|uniprotkb:O50190|uniprotkb:O52147	intact:EBI-749311|uniprotkb:Q969S5|ensembl:ENSP00000310749|ensembl:ENSP00000371184|ensembl:ENSP00000478231|ensembl:ENSP00000482993|ensembl:ENSP00000483786	psi-mi:tir_eco27(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:espE(gene name synonym)|uniprotkb:E2348C_3941(locus name)	psi-mi:hpcl1_human(display_long)|uniprotkb:Visinin-like protein 3(gene name synonym)|uniprotkb:Calcium-binding protein BDR-1(gene name synonym)|uniprotkb:HLP2(gene name synonym)|uniprotkb:HPCAL1(gene name)|psi-mi:HPCAL1(display_short)|uniprotkb:BDR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040327|imex:IM-23549-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:CAS11489(transcript)|ensemblbacteria:E2348C_3941(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR022638|interpro:IPR022639|interpro:IPR037003|rcsb pdb:2CI9|rcsb pdb:2CIA|refseq:WP_001339882.1|dip:DIP-27648N|dip:DIP-55921N|mint:B7UM99	refseq:NP_002140.2|refseq:NP_602293.1|refseq:XP_011508648.1|refseq:XP_011508649.1|refseq:XP_011508650.1|refseq:NP_001245286.1|refseq:NP_001245287.1|refseq:NP_001245288.1|refseq:XP_005246217.1|refseq:XP_005246218.1|refseq:XP_005246219.1|refseq:XP_005246220.1|refseq:XP_016859439.1|refseq:XP_016859440.1|refseq:XP_016859441.1|refseq:XP_016859442.1|ensembl:ENSG00000115756(gene)|ensembl:ENST00000307845(transcript)|ensembl:ENST00000381765(transcript)|ensembl:ENST00000613496(transcript)|ensembl:ENST00000620771(transcript)|ensembl:ENST00000622018(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|rcsb pdb:5T7C	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:KzZZf57ln3nXEZ0Rpn9Tf/B1DCk574521	rogid:oK04sIDCtghEOWIBNQ75bR34+2o9606	intact-crc:33940A83CA48F071|rigid:yE+ULWWGVJZhw2FL6KewnrcBWbw	false	sufficient binding region:1-270(IPR022633)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H3R5	uniprotkb:Q8XB62	intact:EBI-1003700|uniprotkb:A8K3Y1|ensembl:ENSP00000283006	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	psi-mi:cenph_human(display_long)|uniprotkb:Interphase centromere complex protein 35(gene name synonym)|uniprotkb:ICEN35(gene name synonym)|uniprotkb:CENPH(gene name)|psi-mi:CENPH(display_short)	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040223|imex:IM-23549-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075060.1|ensembl:ENSG00000153044(gene)|ensembl:ENST00000283006(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0043515"(kinetochore binding)|go:"GO:0051382"(kinetochore assembly)|go:"GO:0051383"(kinetochore organization)|interpro:IPR040034|mint:Q9H3R5|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025|interpro:IPR008426(Centromere H)	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:NcnQtHH8NhQ2AUePTPR3TRrpqaI9606	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	intact-crc:D871BCB7F1946ABA|rigid:E2ee4xRBiu3oDMgP8APRWAyxul4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HT8	uniprotkb:Q8XB62	intact:EBI-748896|uniprotkb:Q6NXT8|uniprotkb:Q9P0J5|uniprotkb:B2R6R0|ensembl:ENSP00000318154	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	psi-mi:mr1l1_human(display_long)|uniprotkb:PP784(orf name)|uniprotkb:MRFAP1L1(gene name)|psi-mi:MRFAP1L1(display_short)	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040220|imex:IM-23549-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_982287.1|refseq:XP_005247989.1|ensembl:ENSG00000178988(gene)|ensembl:ENST00000320848(transcript)|go:"GO:0042802"(identical protein binding)|interpro:IPR029254|mint:Q96HT8|dip:DIP-29019N	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:6C914B0B4BEECAE5	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:hb4enqSS7DeieOByDoLDkXkSlIk9606	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	intact-crc:A1FBE1C50089F626|rigid:B4DOPbQLC1N4Bvf5sgdEq9FpAVo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7DB77	uniprotkb:Q9UQB8	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039977|imex:IM-23549-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	intact-crc:ED292C9E39772F83|rigid:+FInGdMTTBxacaG2SJDoullzsRQ	false	sufficient binding region:333-558(IPR022639)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49407	uniprotkb:Q7DB77	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039968|imex:IM-23549-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:1B811C9F7BD696A4|rigid:egVpT0wXvb3+UoIaPOCReuZ+1zM	false	-	sufficient binding region:333-558(IPR022639)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:Q7DB77	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039985|imex:IM-23549-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:9A8D7CB76B18E9A4|rigid:VE0c/Qjb0IzvfXI7VcEea+480MY	false	-	sufficient binding region:333-558(IPR022639)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:B7UM99	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-2504426|ensemblbacteria:CAS11489|uniprotkb:O50190|uniprotkb:O52147	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:tir_eco27(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:espE(gene name synonym)|uniprotkb:E2348C_3941(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040334|imex:IM-23549-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	ensemblbacteria:CAS11489(transcript)|ensemblbacteria:E2348C_3941(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR022638|interpro:IPR022639|interpro:IPR037003|rcsb pdb:2CI9|rcsb pdb:2CIA|refseq:WP_001339882.1|dip:DIP-27648N|dip:DIP-55921N|mint:B7UM99	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:KzZZf57ln3nXEZ0Rpn9Tf/B1DCk574521	intact-crc:A32387AE78D730D4|rigid:YLb6A/iF7T7DYnGHWLiXbzYT1LA	false	-	sufficient binding region:338-550(IPR022639)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B7UM99	uniprotkb:P61601	intact:EBI-2504426|ensemblbacteria:CAS11489|uniprotkb:O50190|uniprotkb:O52147	intact:EBI-749635|uniprotkb:P29554|uniprotkb:Q8IYC3|uniprotkb:Q9H0W2|ensembl:ENSP00000220931|ensembl:ENSP00000310587|ensembl:ENSP00000379256|ensembl:ENSP00000428105|ensembl:ENSP00000430476	psi-mi:tir_eco27(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:espE(gene name synonym)|uniprotkb:E2348C_3941(locus name)	psi-mi:ncald_human(display_long)|uniprotkb:NCALD(gene name)|psi-mi:NCALD(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040320|imex:IM-23549-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:CAS11489(transcript)|ensemblbacteria:E2348C_3941(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR022638|interpro:IPR022639|interpro:IPR037003|rcsb pdb:2CI9|rcsb pdb:2CIA|refseq:WP_001339882.1|dip:DIP-27648N|dip:DIP-55921N|mint:B7UM99	refseq:NP_001035714.1|refseq:NP_001035715.1|refseq:NP_001035716.1|refseq:NP_001035717.1|refseq:NP_001035718.1|refseq:NP_001035719.1|refseq:NP_001035720.1|refseq:NP_114430.2|refseq:XP_011515634.1|refseq:XP_011515635.1|refseq:XP_011515636.1|refseq:XP_011515637.1|refseq:XP_016869390.1|refseq:XP_016869391.1|ensembl:ENSG00000104490(gene)|ensembl:ENST00000220931(transcript)|ensembl:ENST00000311028(transcript)|ensembl:ENST00000395923(transcript)|ensembl:ENST00000519508(transcript)|ensembl:ENST00000521599(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0015631"(tubulin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043014"(alpha-tubulin binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P61601|reactome:R-HSA-451308	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:KzZZf57ln3nXEZ0Rpn9Tf/B1DCk574521	rogid:1/KBd+bN0cMZa81XKSSGPxgQEzc9606	intact-crc:99AA4EC1E84267D5|rigid:KOkLD6ohI0DfNhDddALFgKV+UJs	false	sufficient binding region:1-267(IPR022633)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7DB77	uniprotkb:P61601	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-749635|uniprotkb:P29554|uniprotkb:Q8IYC3|uniprotkb:Q9H0W2|ensembl:ENSP00000220931|ensembl:ENSP00000310587|ensembl:ENSP00000379256|ensembl:ENSP00000428105|ensembl:ENSP00000430476	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:ncald_human(display_long)|uniprotkb:NCALD(gene name)|psi-mi:NCALD(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040313|imex:IM-23549-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001035714.1|refseq:NP_001035715.1|refseq:NP_001035716.1|refseq:NP_001035717.1|refseq:NP_001035718.1|refseq:NP_001035719.1|refseq:NP_001035720.1|refseq:NP_114430.2|refseq:XP_011515634.1|refseq:XP_011515635.1|refseq:XP_011515636.1|refseq:XP_011515637.1|refseq:XP_016869390.1|refseq:XP_016869391.1|ensembl:ENSG00000104490(gene)|ensembl:ENST00000220931(transcript)|ensembl:ENST00000311028(transcript)|ensembl:ENST00000395923(transcript)|ensembl:ENST00000519508(transcript)|ensembl:ENST00000521599(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0015631"(tubulin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043014"(alpha-tubulin binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P61601|reactome:R-HSA-451308	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:1/KBd+bN0cMZa81XKSSGPxgQEzc9606	intact-crc:5BFA004CF638B972|rigid:NW9lpVQdfwALyaamEljTN/cqgoo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75716	uniprotkb:Q7DB77	intact:EBI-749295|uniprotkb:Q96KI2|uniprotkb:Q9UEN3|uniprotkb:Q9UP78|uniprotkb:A8K9H9|uniprotkb:Q5U0F8|intact:EBI-1046308|uniprotkb:Q9BUH4|ensembl:ENSP00000379964|ensembl:ENSP00000386928	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:stk16_human(display_long)|uniprotkb:STK16(gene name)|psi-mi:STK16(display_short)|uniprotkb:MPSK1(gene name synonym)|uniprotkb:PKL12(gene name synonym)|uniprotkb:TSF1(gene name synonym)|uniprotkb:Protein kinase PKL12(gene name synonym)|uniprotkb:Myristoylated and palmitoylated serine/threonine-protein kinase(gene name synonym)|uniprotkb:TGF-beta-stimulated factor 1(gene name synonym)|uniprotkb:hPSK(gene name synonym)|uniprotkb:Tyrosine-protein kinase STK16(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040025|imex:IM-23549-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008910.1|refseq:NP_001317142.1|ensembl:ENSG00000115661(gene)|ensembl:ENST00000396738(transcript)|ensembl:ENST00000409638(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2BUJ|dip:DIP-29598N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9eLCQQQFtAQVj2MUxyDLGkniiM49606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:A77D9B43B2CF61A0|rigid:PtFZg2M0P8t6pPCwD5zeyLdixIc	false	-	sufficient binding region:333-558(IPR022639)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6Y2X3	uniprotkb:Q8XA11	intact:EBI-10038974|uniprotkb:A5YM67|uniprotkb:Q17RY2|uniprotkb:Q66K17|uniprotkb:Q96N59|uniprotkb:Q96T63|ensembl:ENSP00000317500|ensembl:ENSP00000350223|ensembl:ENSP00000448876|ensembl:ENSP00000450196|ensembl:ENSP00000504134	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	psi-mi:djc14_human(display_long)|uniprotkb:DNAJC14(gene name)|psi-mi:DNAJC14(display_short)|uniprotkb:DRIP78(gene name synonym)|uniprotkb:HDJ3(gene name synonym)|uniprotkb:DnaJ protein homolog 3(gene name synonym)|uniprotkb:Dopamine receptor-interacting protein of 78 kDa(gene name synonym)|uniprotkb:Human DnaJ protein 3(gene name synonym)	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040281|imex:IM-23549-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115740.5|ensembl:ENSG00000135392(gene)|ensembl:ENST00000317287(transcript)|ensembl:ENST00000357606(transcript)|ensembl:ENST00000546957(transcript)|ensembl:ENST00000547445(transcript)|ensembl:ENST00000678005(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR032843|interpro:IPR036869|mint:Q6Y2X3	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:oS3c968UKq0i0JRZxUJFskA5HD89606	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	intact-crc:17C08145398DABB8|rigid:zrdoJVyFVTprLL5aBAyHrVWpLOk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XA11	uniprotkb:P62191	intact:EBI-10038919|uniprotkb:Q7AHS4|ensemblbacteria:BAB33484|ensemblbacteria:QCH84714|uniprotkb:A0A0H3JC43	intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63	psi-mi:q8xa11_eco57(display_long)|uniprotkb:E5F08_03670(orf name)|uniprotkb:espY1(gene name)|psi-mi:espY1(display_short)|uniprotkb:ECs_0061(orf name)	psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040275|imex:IM-23549-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001646(Pentapeptide repeat)|refseq:WP_001304001.1|refseq:NP_308088.1|ensemblbacteria:BAB33484(transcript)|ensemblbacteria:CAM50_0024520(gene)|ensemblbacteria:ECs_0061(gene)|ensemblbacteria:QCH84714(transcript)	refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Wcj5te52gWAr/zHWrvjervg1eqs83334	rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606	intact-crc:C047496D5973FCCE|rigid:BQnzh2juILO/0YE9dI5RQvjokTc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAL7	uniprotkb:Q96Q11	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-2839106|uniprotkb:Q9Y362|uniprotkb:Q9BS97|uniprotkb:Q8ND57|uniprotkb:A8K2Z6|uniprotkb:B7WP13|uniprotkb:C9JKA2|ensembl:ENSP00000251607|ensembl:ENSP00000415100	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:trnt1_human(display_long)|uniprotkb:TRNT1(gene name)|psi-mi:TRNT1(display_short)|uniprotkb:Mitochondrial tRNA nucleotidyl transferase, CCA-adding(gene name synonym)|uniprotkb:mt CCA-adding enzyme(gene name synonym)|uniprotkb:mt tRNA CCA-diphosphorylase(gene name synonym)|uniprotkb:mt tRNA CCA-pyrophosphorylase(gene name synonym)|uniprotkb:mt tRNA adenylyltransferase(gene name synonym)|uniprotkb:CGI-47(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040265|imex:IM-23549-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:XP_011532078.1|refseq:XP_011532079.1|refseq:XP_011532080.1|ensembl:ENSG00000072756(gene)|ensembl:ENST00000251607(transcript)|ensembl:ENST00000434583(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001680"(tRNA 3'-terminal CCA addition)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016437"(tRNA cytidylyltransferase activity)|go:"GO:0034062"(5'-3' RNA polymerase activity)|go:"GO:0042780"(tRNA 3'-end processing)|go:"GO:0052927"("CTP:tRNA cytidylyltransferase activity")|go:"GO:0052928"("CTP:3'-cytidine-tRNA cytidylyltransferase activity")|go:"GO:0052929"("ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity")|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR002646(Polynucleotide adenylyltransferase region)|interpro:IPR032828|interpro:IPR043519|rcsb pdb:1OU5|rcsb pdb:4X4W|reactome:R-HSA-6785470|reactome:R-HSA-6784531|refseq:NP_001289875.1|refseq:NP_886552.2	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:COxi4PrWifNnDPkI+lile/5kD9I9606	intact-crc:8B43DDC5C28FCFAD|rigid:2fkFc3ICDs1nvcYYs5P7hqnjtmI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XAL7	uniprotkb:O43414	intact:EBI-10039292|uniprotkb:Q7AEM9|ensemblbacteria:AAK16936|ensemblbacteria:BAB35238	intact:EBI-9679612|uniprotkb:B1AK98|uniprotkb:Q5T2T7|uniprotkb:Q5T2T9|uniprotkb:Q5TG35|uniprotkb:Q9BQA0|uniprotkb:Q9UEB4|ensembl:ENSP00000361331	psi-mi:nlef_eco57(display_long)|uniprotkb:nleF(gene name)|psi-mi:nleF(display_short)|uniprotkb:Non-LEE-encoded type III effector F(gene name synonym)|uniprotkb:Z6020.1(locus name)|uniprotkb:ECs1815(locus name)	psi-mi:eri3_human(display_long)|uniprotkb:ERI3(gene name)|psi-mi:ERI3(display_short)|uniprotkb:PINT1(gene name synonym)|uniprotkb:PRNPIP(gene name synonym)|uniprotkb:PRNPIP1(gene name synonym)|uniprotkb:Prion interactor 1(gene name synonym)|uniprotkb:Prion protein-interacting protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040258|imex:IM-23549-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_309842.1|interpro:IPR031829|refseq:WP_000938103.1|ensemblbacteria:AAK16936(transcript)|ensemblbacteria:BAB35238(transcript)|ensemblbacteria:ECs_1815(gene)|ensemblbacteria:Z6020(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030430"(host cell cytoplasm)|rcsb pdb:3V3K|mint:Q8XAL7|interpro:IPR038334	refseq:NP_001288627.1|refseq:NP_001288628.1|refseq:NP_001288629.1|refseq:NP_001288630.1|ensembl:ENSP00000361331|ensembl:ENST00000372259|ensembl:ENSP00000361333|refseq:NP_076971.1|ensembl:ENSG00000117419(gene)|ensembl:ENST00000372257(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036397|mint:O43414|rcsb pdb:2XRI	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:HkXeuy5go7xh1ktNxTnkZDm0YLw83334	rogid:Ke3BT8EH5uiVr+FunIbBBwvh/bM9606	intact-crc:1C9B5E0EE1D93E51|rigid:0ZVXKihI+3/vwEnITaIrN+fXQ4E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96IZ6	uniprotkb:A0A0H3JGR6	intact:EBI-7211882|uniprotkb:A6NNC4|uniprotkb:Q9P0B5|uniprotkb:Q9H9G9|uniprotkb:Q9NUI8|intact:MINT-3054259|ensembl:ENSP00000309610	intact:EBI-10039274|ensemblbacteria:BAB34273|ensemblbacteria:QCH83944|uniprotkb:A0A7U8R338|uniprotkb:A0A6M0JIH9|uniprotkb:A0A6M7CAZ4	psi-mi:met2a_human(display_long)|uniprotkb:METTL2A(gene name)|psi-mi:METTL2A(display_short)|uniprotkb:METTL2(gene name synonym)|uniprotkb:Methyltransferase-like protein 2A(gene name synonym)|uniprotkb:HSPC266(orf name)	psi-mi:a0a0h3jgr6_eco57(display_long)|uniprotkb:E5F08_07770(orf name)|uniprotkb:nleD(gene name)|psi-mi:nleD(display_short)|uniprotkb:ECs_0850(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040249|imex:IM-23549-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_859076.3|ensembl:ENSG00000087995(gene)|ensembl:ENST00000311506(transcript)|go:"GO:0016427"("tRNA (cytosine) methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0052735"("tRNA (cytosine-3-)-methyltransferase activity")|interpro:IPR026113|interpro:IPR029063	uniprotkb:Q7AGE0(uniprot-removed-ac)|refseq:NP_308877.1|refseq:WP_001247925.1|interpro:IPR028208|ensemblbacteria:BAB34273(transcript)|ensemblbacteria:CAM50_0020160(gene)|ensemblbacteria:ECs_0850(gene)|ensemblbacteria:QCH83944(transcript)	-	comment:mint|function:Probable methyltransferase|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:UDMjkoiVoFtAUI7N3PDqj5ELSFI9606	rogid:zkF+5p88ddmXoI6VON0GRkdetcU83334	intact-crc:44F415A68133A178|rigid:mLvQ55YwmTtroKvdTxrjyulJLrQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XBX8	uniprotkb:P55039	intact:EBI-10039153|uniprotkb:Q7AAV0|ensemblbacteria:BAB37280|ensemblbacteria:QCH81151|uniprotkb:A0A0H3JHS6|uniprotkb:A0A6M0JF43	intact:EBI-750565|uniprotkb:Q9BWB2|uniprotkb:B2R8G5|uniprotkb:Q53Y50|ensembl:ENSP00000225729	psi-mi:nleb1_eco57(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:ECs_3857(orf name)	psi-mi:drg2_human(display_long)|uniprotkb:DRG2(gene name)|psi-mi:DRG2(display_short)|uniprotkb:Translation factor GTPase DRG2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040246|imex:IM-23549-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_311884.1|refseq:WP_000953022.1|ensemblbacteria:BAB37280(transcript)|ensemblbacteria:CAM50_0004305(gene)|ensemblbacteria:ECs_3857(gene)|ensemblbacteria:QCH81151(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)	refseq:NP_001379.1|ensembl:ENSG00000108591(gene)|ensembl:ENST00000225729(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR004095(TGS)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006074(GTP1/OBG, conserved site)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR027417|interpro:IPR031167|interpro:IPR031662|interpro:IPR012676(TGS-like)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:s08ivrjNoMdHHNcIwH+V7ZobNOQ83334	rogid:9bgX8C0kJmO5KdaYHU+vAmDCTPo9606	intact-crc:9F0E8E1D80FCB104|rigid:dD+KM+yBSkP8/jr7kNRM9Vf95Rw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q93096	uniprotkb:Q8XAJ5	intact:EBI-1058467|uniprotkb:O00648|uniprotkb:Q49A54|uniprotkb:B2R6C8|intact:EBI-1640492|ensembl:ENSP00000485687|ensembl:ENSP00000497588|ensembl:ENSP00000500859|ensembl:ENSP00000500952	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	psi-mi:tp4a1_human(display_long)|uniprotkb:PTP4A1(gene name)|psi-mi:PTP4A1(display_short)|uniprotkb:PRL1(gene name synonym)|uniprotkb:PTPCAAX1(gene name synonym)|uniprotkb:"PTP(CAAXI)"(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 4a1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase of regenerating liver 1(gene name synonym)	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040239|imex:IM-23549-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003454.1|ensembl:ENSG00000112245(gene)|ensembl:ENST00000626021(transcript)|ensembl:ENST00000648894(transcript)|ensembl:ENST00000672924(transcript)|ensembl:ENST00000673199(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0007049"(cell cycle)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR020422|interpro:IPR029021|rcsb pdb:1RXD|rcsb pdb:1XM2|rcsb pdb:5BX1|refseq:XP_016866759.1|refseq:XP_016866760.1|refseq:XP_011534413.1|refseq:XP_011534414.1	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:Eza5NsYNd+5ml6QEEmkQv5pAZ789606	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	intact-crc:DD7E7A60E1478383|rigid:34CyLoE6+8jRAPYLPlLJhU14uWc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56555	uniprotkb:Q8XAJ5	intact:EBI-10039117|uniprotkb:Q4VB31	intact:EBI-10039107|uniprotkb:Q7AEN2|ensemblbacteria:BAB35235|ensemblbacteria:QCH82721|uniprotkb:A0A0H3JEG7|uniprotkb:A0A6M0JSD1	psi-mi:dscr4_human(display_long)|uniprotkb:DSCR4(gene name)|psi-mi:DSCR4(display_short)|uniprotkb:DCRB(gene name synonym)|uniprotkb:DSCRB(gene name synonym)|uniprotkb:Down syndrome critical region protein B(gene name synonym)	psi-mi:q8xaj5_eco57(display_long)|uniprotkb:E5F08_14940(orf name)|uniprotkb:nleA(gene name)|psi-mi:nleA(display_short)|uniprotkb:espI(gene name synonym)|uniprotkb:ECs_1812(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040229|imex:IM-23549-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005858.1	refseq:NP_309839.1|refseq:WP_001025672.1|ensemblbacteria:BAB35235(transcript)|ensemblbacteria:CAM50_0013185(gene)|ensemblbacteria:ECs_1812(gene)|ensemblbacteria:QCH82721(transcript)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:ObILr2wYLN3Wg8advbNI6ZaAta89606	rogid:ZP/LIKGH/FXS6bNOJyNxNGXCH8883334	intact-crc:3B6AB376B9747164|rigid:FcSGEjJGaaly873gwKO+F9MXyfs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13287	uniprotkb:Q7DB50	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	intact:EBI-6379656|ensemblbacteria:BAB38013|uniprotkb:Q7A9M3|uniprotkb:A0A6M0JN46	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:q7db50_eco57(display_long)|uniprotkb:espG(gene name)|psi-mi:espG(display_short)|uniprotkb:ECs_4590(orf name)|uniprotkb:E5F08_27545(orf name)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040213|imex:IM-23549-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	refseq:NP_312617.1|ensemblbacteria:BAB38013(transcript)|ensemblbacteria:ECs_4590(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|interpro:IPR009669(EspG)|rcsb pdb:3PCR|rcsb pdb:3PCS|rcsb pdb:4FMC|rcsb pdb:4FMD|rcsb pdb:4FME|refseq:WP_001301460.1|interpro:IPR043098	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2018/10/11	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rogid:g7FQ+G0CKEqSrzN+2H+OAnLu7No83334	intact-crc:A34D2B97ED29009F|rigid:ECozAgrWsBgj/lxMRGMTozaWyr8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XB62	uniprotkb:Q9NPQ8	intact:EBI-10038787|uniprotkb:Q7ACX7|ensemblbacteria:BAB36137|ensemblbacteria:QCH82256|uniprotkb:A0A0H3JG75|uniprotkb:A0A6M0JSQ6	intact:EBI-717509|uniprotkb:Q0P508|uniprotkb:Q2T9J1|uniprotkb:Q7Z352|uniprotkb:Q96EZ1|uniprotkb:Q96SZ2|uniprotkb:Q9H064|uniprotkb:Q9H5H3|uniprotkb:Q9H9E7|ensembl:ENSP00000432008	psi-mi:q8xb62_eco57(display_long)|uniprotkb:E5F08_17465(orf name)|uniprotkb:espJ(gene name)|psi-mi:espJ(display_short)|uniprotkb:ECs_2714(orf name)	psi-mi:ric8a_human(display_long)|uniprotkb:Protein Ric-8A(gene name synonym)|uniprotkb:RIC8A(gene name)|psi-mi:RIC8A(display_short)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040217|imex:IM-23549-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015226(AvrPphF ORF-2)|refseq:NP_310741.1|refseq:WP_000022458.1|ensemblbacteria:BAB36137(transcript)|ensemblbacteria:CAM50_0010550(gene)|ensemblbacteria:ECs_2714(gene)|ensemblbacteria:QCH82256(transcript)	refseq:NP_001273063.1|refseq:NP_068751.4|refseq:XP_016873596.1|ensembl:ENSG00000177963(gene)|ensembl:ENST00000526104(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0070586"(cell-cell adhesion involved in gastrulation)|go:"GO:0071711"(basement membrane organization)|interpro:IPR008376(Synembryn)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019318|mint:Q9NPQ8|go:"GO:0001965"(G-protein alpha-subunit binding)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:pwnhf6VxgSKHIqJxvoUGpqp7Iu083334	rogid:jNCxRLnDY2aSw6SMtE82Tny1IE89606	intact-crc:798082DCDEDA03AB|rigid:G9MzjwIAron9qJW3oXc71+l1qos	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8XC86	uniprotkb:Q9BYM8	intact:EBI-10038594|uniprotkb:Q7A9Q6|ensemblbacteria:BAB37977|ensemblbacteria:QCH80454|uniprotkb:A0A0H3JJC8|uniprotkb:A0A6M0JLD0	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	psi-mi:q8xc86_eco57(display_long)|uniprotkb:E5F08_27370(orf name)|uniprotkb:espB(gene name)|psi-mi:espB(display_short)|uniprotkb:ECs_4554(orf name)	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040186|imex:IM-23549-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008611(Enterobacterial EspB)|refseq:NP_312581.1|refseq:WP_001092000.1|ensemblbacteria:BAB37977(transcript)|ensemblbacteria:CAM50_0000445(gene)|ensemblbacteria:ECs_4554(gene)|ensemblbacteria:QCH80454(transcript)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:9cKWrLKb1089HnklaM95O3OLdTQ83334	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	intact-crc:B470756CDAC2FA52|rigid:Cr3FpGA3wpV+Ewb6qFIbZAB7y2g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B7UM99	uniprotkb:O75716	intact:EBI-2504426|ensemblbacteria:CAS11489|uniprotkb:O50190|uniprotkb:O52147	intact:EBI-749295|uniprotkb:Q96KI2|uniprotkb:Q9UEN3|uniprotkb:Q9UP78|uniprotkb:A8K9H9|uniprotkb:Q5U0F8|intact:EBI-1046308|uniprotkb:Q9BUH4|ensembl:ENSP00000379964|ensembl:ENSP00000386928	psi-mi:tir_eco27(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:espE(gene name synonym)|uniprotkb:E2348C_3941(locus name)	psi-mi:stk16_human(display_long)|uniprotkb:STK16(gene name)|psi-mi:STK16(display_short)|uniprotkb:MPSK1(gene name synonym)|uniprotkb:PKL12(gene name synonym)|uniprotkb:TSF1(gene name synonym)|uniprotkb:Protein kinase PKL12(gene name synonym)|uniprotkb:Myristoylated and palmitoylated serine/threonine-protein kinase(gene name synonym)|uniprotkb:TGF-beta-stimulated factor 1(gene name synonym)|uniprotkb:hPSK(gene name synonym)|uniprotkb:Tyrosine-protein kinase STK16(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10040304|imex:IM-23549-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:CAS11489(transcript)|ensemblbacteria:E2348C_3941(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR022638|interpro:IPR022639|interpro:IPR037003|rcsb pdb:2CI9|rcsb pdb:2CIA|refseq:WP_001339882.1|dip:DIP-27648N|dip:DIP-55921N|mint:B7UM99	refseq:NP_001008910.1|refseq:NP_001317142.1|ensembl:ENSG00000115661(gene)|ensembl:ENST00000396738(transcript)|ensembl:ENST00000409638(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2BUJ|dip:DIP-29598N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/12/10	2014/12/10	rogid:KzZZf57ln3nXEZ0Rpn9Tf/B1DCk574521	rogid:9eLCQQQFtAQVj2MUxyDLGkniiM49606	intact-crc:DA9ED312413DE6E2|rigid:lMWC0234Z1g7aKWhVEk5UZffGQw	false	sufficient binding region:338-550(IPR022639)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7DB77	uniprotkb:O75716	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-749295|uniprotkb:Q96KI2|uniprotkb:Q9UEN3|uniprotkb:Q9UP78|uniprotkb:A8K9H9|uniprotkb:Q5U0F8|intact:EBI-1046308|uniprotkb:Q9BUH4|ensembl:ENSP00000379964|ensembl:ENSP00000386928	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:stk16_human(display_long)|uniprotkb:STK16(gene name)|psi-mi:STK16(display_short)|uniprotkb:MPSK1(gene name synonym)|uniprotkb:PKL12(gene name synonym)|uniprotkb:TSF1(gene name synonym)|uniprotkb:Protein kinase PKL12(gene name synonym)|uniprotkb:Myristoylated and palmitoylated serine/threonine-protein kinase(gene name synonym)|uniprotkb:TGF-beta-stimulated factor 1(gene name synonym)|uniprotkb:hPSK(gene name synonym)|uniprotkb:Tyrosine-protein kinase STK16(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039863|imex:IM-23549-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001008910.1|refseq:NP_001317142.1|ensembl:ENSG00000115661(gene)|ensembl:ENST00000396738(transcript)|ensembl:ENST00000409638(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:2BUJ|dip:DIP-29598N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:9eLCQQQFtAQVj2MUxyDLGkniiM49606	intact-crc:066BE343F3AB2090|rigid:PtFZg2M0P8t6pPCwD5zeyLdixIc	false	protein a tag:?-?	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P37235	uniprotkb:Q7DB77	intact:EBI-749311|uniprotkb:Q969S5|ensembl:ENSP00000310749|ensembl:ENSP00000371184|ensembl:ENSP00000478231|ensembl:ENSP00000482993|ensembl:ENSP00000483786	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:hpcl1_human(display_long)|uniprotkb:Visinin-like protein 3(gene name synonym)|uniprotkb:Calcium-binding protein BDR-1(gene name synonym)|uniprotkb:HLP2(gene name synonym)|uniprotkb:HPCAL1(gene name)|psi-mi:HPCAL1(display_short)|uniprotkb:BDR1(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039826|imex:IM-23549-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002140.2|refseq:NP_602293.1|refseq:XP_011508648.1|refseq:XP_011508649.1|refseq:XP_011508650.1|refseq:NP_001245286.1|refseq:NP_001245287.1|refseq:NP_001245288.1|refseq:XP_005246217.1|refseq:XP_005246218.1|refseq:XP_005246219.1|refseq:XP_005246220.1|refseq:XP_016859439.1|refseq:XP_016859440.1|refseq:XP_016859441.1|refseq:XP_016859442.1|ensembl:ENSG00000115756(gene)|ensembl:ENST00000307845(transcript)|ensembl:ENST00000381765(transcript)|ensembl:ENST00000613496(transcript)|ensembl:ENST00000620771(transcript)|ensembl:ENST00000622018(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|rcsb pdb:5T7C	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:oK04sIDCtghEOWIBNQ75bR34+2o9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:02C53A1F8DF9043E|rigid:1cwDS9Ro06Jrm9ll7Abp4YUxFYM	false	renilla luciferase protein tag:?-?	protein a tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q9UHR4	uniprotkb:Q7DB77	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039820|imex:IM-23549-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:7B7CF8783B6B75DC|rigid:VE0c/Qjb0IzvfXI7VcEea+480MY	false	renilla luciferase protein tag:?-?	protein a tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q7DB77	uniprotkb:P61601	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-749635|uniprotkb:P29554|uniprotkb:Q8IYC3|uniprotkb:Q9H0W2|ensembl:ENSP00000220931|ensembl:ENSP00000310587|ensembl:ENSP00000379256|ensembl:ENSP00000428105|ensembl:ENSP00000430476	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:ncald_human(display_long)|uniprotkb:NCALD(gene name)|psi-mi:NCALD(display_short)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039836|imex:IM-23549-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001035714.1|refseq:NP_001035715.1|refseq:NP_001035716.1|refseq:NP_001035717.1|refseq:NP_001035718.1|refseq:NP_001035719.1|refseq:NP_001035720.1|refseq:NP_114430.2|refseq:XP_011515634.1|refseq:XP_011515635.1|refseq:XP_011515636.1|refseq:XP_011515637.1|refseq:XP_016869390.1|refseq:XP_016869391.1|ensembl:ENSG00000104490(gene)|ensembl:ENST00000220931(transcript)|ensembl:ENST00000311028(transcript)|ensembl:ENST00000395923(transcript)|ensembl:ENST00000519508(transcript)|ensembl:ENST00000521599(transcript)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0015631"(tubulin binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0043014"(alpha-tubulin binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P61601|reactome:R-HSA-451308	-	-	-	figure legend:Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:1/KBd+bN0cMZa81XKSSGPxgQEzc9606	intact-crc:45998EC2F51A01F1|rigid:NW9lpVQdfwALyaamEljTN/cqgoo	false	protein a tag:?-?	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q9UQB8	uniprotkb:Q7DB77	intact:EBI-525456|uniprotkb:O43858|uniprotkb:Q53HB1|uniprotkb:Q86WC1|uniprotkb:Q8N5C0|uniprotkb:Q96CR7|uniprotkb:Q9UBR3|uniprotkb:Q9UQ43|ensembl:ENSP00000316338	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:baip2_human(display_long)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Insulin receptor substrate p53/p58(gene name synonym)|uniprotkb:Fas ligand-associated factor 3(gene name synonym)|uniprotkb:BAIAP2(gene name)|psi-mi:BAIAP2(display_short)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039893|imex:IM-23549-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138360.1|refseq:NP_006331.1|refseq:NP_059344.1|refseq:NP_059345.1|refseq:XP_005257005.1|dip:DIP-29272N|go:"GO:0009617"(response to bacterium)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q9UQB8|rcsb pdb:1WDZ|rcsb pdb:1Y2O|rcsb pdb:2YKT|rcsb pdb:3RNJ|rcsb pdb:4JS0|rcsb pdb:6BCR|rcsb pdb:6BCY|rcsb pdb:6BD1|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6ZEG|rcsb pdb:6ZEI|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000175866(gene)|ensembl:ENST00000321300(transcript)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:BRbjAYBnAJN0Pzb7bc/Qtb4w5bY9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:25844F427F58544E|rigid:+FInGdMTTBxacaG2SJDoullzsRQ	false	renilla luciferase protein tag:?-?	protein a tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:P49407	uniprotkb:Q7DB77	intact:EBI-743313|uniprotkb:O75625|uniprotkb:O75630|uniprotkb:Q2PP20|uniprotkb:Q9BTK8|intact:EBI-2561130|uniprotkb:B6V9G8|ensembl:ENSP00000409581	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:arrb1_human(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:ARRB1(gene name)|psi-mi:ARRB1(display_short)|uniprotkb:ARR1(gene name synonym)|uniprotkb:Non-visual arrestin-2(gene name synonym)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039808|imex:IM-23549-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004032.2|refseq:NP_064647.1|ensembl:ENSG00000137486(gene)|ensembl:ENST00000420843(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016573"(histone acetylation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042493"|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:P49407|rcsb pdb:2IV8|rcsb pdb:6PWC|rcsb pdb:6TKO|rcsb pdb:6UP7|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-456926|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|dip:DIP-29979N	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:UNYbZY5saRx8CwJ8Jwt3QtjXgj09606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:85EEED8F81C53041|rigid:egVpT0wXvb3+UoIaPOCReuZ+1zM	false	renilla luciferase protein tag:?-?	protein a tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q9UM19	uniprotkb:Q7DB77	intact:EBI-744820|uniprotkb:Q5TG97|uniprotkb:Q8N611|uniprotkb:B2R5U2|uniprotkb:D3DPU1|ensembl:ENSP00000361935|ensembl:ENSP00000481834	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	psi-mi:hpcl4_human(display_long)|uniprotkb:HPCAL4(gene name)|psi-mi:HPCAL4(display_short)	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039832|imex:IM-23549-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057341.1|ensembl:ENSG00000116983(gene)|ensembl:ENST00000617690(transcript)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|interpro:IPR029534|ensembl:ENST00000372844(transcript)|refseq:NP_001269325.1|refseq:XP_016856936.1	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:+2KFQ7WO9Kyn14ySKaEmm1V6pRM9606	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	intact-crc:DFD734999E07BEB3|rigid:1IogbQyoEvXFZXTvTXzoGXPvL0A	false	renilla luciferase protein tag:?-?	protein a tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)
uniprotkb:Q7DB77	uniprotkb:O43924	intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396	intact:EBI-712685|uniprotkb:O43250|ensembl:ENSP00000287600	psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name)	psi-mi:pde6d_human(display_long)|uniprotkb:Protein p17(gene name synonym)|uniprotkb:PDE6D(gene name)|psi-mi:PDE6D(display_short)|uniprotkb:PDED(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Blasche et al. (2014)	pubmed:25519916|imex:IM-23549	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10039853|imex:IM-23549-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003	refseq:NP_001277947.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050896"(response to stimulus)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017287(Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit)|interpro:IPR037036|mint:O43924|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:3T5G|rcsb pdb:3T5I|rcsb pdb:4JHP|rcsb pdb:4JV6|rcsb pdb:4JV8|rcsb pdb:4JVB|rcsb pdb:4JVF|rcsb pdb:5E80|rcsb pdb:5E8F|rcsb pdb:5F2U|rcsb pdb:5ML2|rcsb pdb:5ML3|rcsb pdb:5ML4|rcsb pdb:5ML6|rcsb pdb:5ML8|rcsb pdb:5NAL|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5X72|rcsb pdb:5X73|rcsb pdb:5X74|rcsb pdb:5YAV|rcsb pdb:5YAW|reactome:R-HSA-5624958|ensembl:ENSG00000156973(gene)|ensembl:ENST00000287600(transcript)|go:"GO:0005095"(GTPase inhibitor activity)|reactome:R-HSA-9648002|refseq:NP_002592.1|dip:DIP-36660N	-	-	-	figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/12/10	2014/12/10	rogid:w091zQ2yloHiTr07621yQtr7n0w83334	rogid:dfEOckvNZPhkWSeQnKr4ugEdEmM9606	intact-crc:7ED05ADD37267440|rigid:nSx3EzGVFU/94uLHaqDzzak+8G8	false	protein a tag:?-?	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:1220"(tag visualisation by luciferase assay)