#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13478	uniprotkb:Q14116	intact:EBI-9817499|uniprotkb:B2R9Y5|uniprotkb:Q52LC9|ensembl:ENSP00000233957|ensembl:ENSP00000386663|ensembl:ENSP00000387211	intact:EBI-3910835|uniprotkb:Q6FGY3|uniprotkb:O75599|intact:EBI-11016725|uniprotkb:Q6WWJ7|ensembl:ENSP00000280357|ensembl:ENSP00000434161	psi-mi:il18r_human(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:IL18R1(gene name)|psi-mi:IL18R1(display_short)|uniprotkb:IL1RRP(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:CDw218a(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)	psi-mi:il18_human(display_long)|uniprotkb:IL18(gene name)|psi-mi:IL18(display_short)|uniprotkb:IGIF(gene name synonym)|uniprotkb:IL1F4(gene name synonym)|uniprotkb:Iboctadekin(gene name synonym)|uniprotkb:Interferon gamma-inducing factor(gene name synonym)|uniprotkb:Interleukin-1 gamma(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wei et al. (2014)	imex:IM-23178|pubmed:25261253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9817497|imex:IM-23178-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269328.1|refseq:NP_003846.1|ensembl:ENSG00000115604(gene)|ensembl:ENST00000233957(transcript)|ensembl:ENST00000409599(transcript)|ensembl:ENST00000410040(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4R6U|reactome:R-HSA-9008059|reactome:R-HSA-9012546	refseq:XP_011541107.1|refseq:XP_011541108.1|refseq:NP_001553.1|refseq:NP_001230140.1|ensembl:ENSG00000150782(gene)|ensembl:ENST00000280357(transcript)|ensembl:ENST00000528832(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030431"(sleep)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045515"(interleukin-18 receptor binding)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000975(Interleukin-1)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR015529(Interleukin 18)|rcsb pdb:1J0S|rcsb pdb:2VXT|rcsb pdb:3F62|rcsb pdb:3WO2|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4EEE|rcsb pdb:4EKX|rcsb pdb:4HJJ|rcsb pdb:4R6U|rcsb pdb:4XFS|rcsb pdb:4XFT|rcsb pdb:4XFU|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9012546|reactome:R-HSA-9660826|dip:DIP-3785N	rcsb pdb:4R6U	-	-	figure legend:t1 f1 f3 f4 sf2|comment:"The final model in the asymmetric unit contains two  IL-18-IL-18Rα complexes (Figure S2A), with residues Tyr1-Asn155 in IL-18 and  residues Ser21-Cys43, Thr51-Arg71, Arg75-Leu161, Pro169-GLu253, and  Asn260-Asp318 in IL-18Rα."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/16	2014/10/16	rogid:K4PnkP3Uh41ui9Qtoi0jxLICdHM9606	rogid:EVCxJD7iNTtAvALzE8GSjbFMWik9606	intact-crc:B1F0443BE3A07C2D|rigid:k7I2A482vBZMR6GCC8cjXG6jVU0	false	binding-associated region:19-329	binding-associated region:37-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14116	uniprotkb:Q13478	intact:EBI-3910835|uniprotkb:Q6FGY3|uniprotkb:O75599|intact:EBI-11016725|uniprotkb:Q6WWJ7|ensembl:ENSP00000280357|ensembl:ENSP00000434161	intact:EBI-9817499|uniprotkb:B2R9Y5|uniprotkb:Q52LC9|ensembl:ENSP00000233957|ensembl:ENSP00000386663|ensembl:ENSP00000387211	psi-mi:il18_human(display_long)|uniprotkb:IL18(gene name)|psi-mi:IL18(display_short)|uniprotkb:IGIF(gene name synonym)|uniprotkb:IL1F4(gene name synonym)|uniprotkb:Iboctadekin(gene name synonym)|uniprotkb:Interferon gamma-inducing factor(gene name synonym)|uniprotkb:Interleukin-1 gamma(gene name synonym)	psi-mi:il18r_human(display_long)|uniprotkb:Interleukin-18 receptor alpha(gene name synonym)|uniprotkb:IL18R1(gene name)|psi-mi:IL18R1(display_short)|uniprotkb:IL1RRP(gene name synonym)|uniprotkb:CD218 antigen-like family member A(gene name synonym)|uniprotkb:CDw218a(gene name synonym)|uniprotkb:IL1 receptor-related protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wei et al. (2014)	imex:IM-23178|pubmed:25261253	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9817760|imex:IM-23178-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541107.1|refseq:XP_011541108.1|refseq:NP_001553.1|refseq:NP_001230140.1|ensembl:ENSG00000150782(gene)|ensembl:ENST00000280357(transcript)|ensembl:ENST00000528832(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030431"(sleep)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045515"(interleukin-18 receptor binding)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000975(Interleukin-1)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR015529(Interleukin 18)|rcsb pdb:1J0S|rcsb pdb:2VXT|rcsb pdb:3F62|rcsb pdb:3WO2|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4EEE|rcsb pdb:4EKX|rcsb pdb:4HJJ|rcsb pdb:4R6U|rcsb pdb:4XFS|rcsb pdb:4XFT|rcsb pdb:4XFU|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9012546|reactome:R-HSA-9660826|dip:DIP-3785N	refseq:NP_001269328.1|refseq:NP_003846.1|ensembl:ENSG00000115604(gene)|ensembl:ENST00000233957(transcript)|ensembl:ENST00000409599(transcript)|ensembl:ENST00000410040(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042007"(interleukin-18 binding)|go:"GO:0042008"(interleukin-18 receptor activity)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045092"(interleukin-18 receptor complex)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4R6U|reactome:R-HSA-9008059|reactome:R-HSA-9012546	rcsb pdb:4R6U	-	-	figure legend:sf1b|comment:"The purified IL-18 (residues Tyr1-Asp157) bound to human IL-18Rα ectodomain (residues Ala19-Arg329), which was expressed and purified from insect cells, to form the IL-18-IL-18Rα complex (Figure S1B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/16	2014/10/16	rogid:EVCxJD7iNTtAvALzE8GSjbFMWik9606	rogid:K4PnkP3Uh41ui9Qtoi0jxLICdHM9606	intact-crc:C7954635FEA29709|rigid:k7I2A482vBZMR6GCC8cjXG6jVU0	false	binding-associated region:37-193	binding-associated region:19-329	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)