#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62745	uniprotkb:Q9HCE7-2	intact:EBI-602647|uniprotkb:P01121|uniprotkb:Q5U0H6|uniprotkb:Q7RTN5|uniprotkb:Q7RTR9|uniprotkb:Q9CUV7|uniprotkb:B2R692|ensembl:ENSP00000272233	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:rhob_human(display_long)|uniprotkb:Rho cDNA clone 6(gene name synonym)|uniprotkb:RHOB(gene name)|psi-mi:RHOB(display_short)|uniprotkb:ARH6(gene name synonym)|uniprotkb:ARHB(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845738|imex:IM-23200-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004031.1|ensembl:ENSG00000143878(gene)|ensembl:ENST00000272233(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62745|rcsb pdb:2FV8|rcsb pdb:6HXU|rcsb pdb:6SGE|reactome:R-HSA-114604|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013026|interpro:IPR003578(Ras small GTPase, Rho type)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 1d, Suppl. Fig. 17|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/10/13	2014/10/16	rogid:Ek7MCYtpm3JJ78E6nwU/Q9rWZmQ9606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:43D8A68E6017DC28|rigid:VIWMo/RNM604yZgwx4IzbPC6x1s	false	-	flag tag:?-?|mutation:699-699	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HCE7-2	uniprotkb:P62745	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-602647|uniprotkb:P01121|uniprotkb:Q5U0H6|uniprotkb:Q7RTN5|uniprotkb:Q7RTR9|uniprotkb:Q9CUV7|uniprotkb:B2R692|ensembl:ENSP00000272233	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:rhob_human(display_long)|uniprotkb:Rho cDNA clone 6(gene name synonym)|uniprotkb:RHOB(gene name)|psi-mi:RHOB(display_short)|uniprotkb:ARH6(gene name synonym)|uniprotkb:ARHB(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845771|imex:IM-23200-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	refseq:NP_004031.1|ensembl:ENSG00000143878(gene)|ensembl:ENST00000272233(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62745|rcsb pdb:2FV8|rcsb pdb:6HXU|rcsb pdb:6SGE|reactome:R-HSA-114604|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013026|interpro:IPR003578(Ras small GTPase, Rho type)	-	-	-	figure legend:Fig. 1e, 2a, Suppl. Fig. 17|causality statement:Q9HCE7-2 increases degradation at protein level of P62745|causality statement:Q9HCE7-2 is required for ubiquitination of P62745|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/10/16	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:Ek7MCYtpm3JJ78E6nwU/Q9rWZmQ9606	intact-crc:533F8391698AEE66|rigid:VIWMo/RNM604yZgwx4IzbPC6x1s	false	glutathione s tranferase tag:n-n|sufficient binding region:1-159(IPR000008)|sufficient binding region:346-731(IPR000569)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HCE7-2	uniprotkb:O14757	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9847123|imex:IM-23200-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	-	-	-	figure legend:Fig. 8d, Suppl. Fig. 18|causality statement:O14757 is required for phosphorylation of Q9HCE7-2|causality statement:O14757 decreases quantity of Q9HCE7-2|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/10/16	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	intact-crc:C42E8F3D6F76D7CE|rigid:PvunxJU8Qs7Kl0GoAJ+eLIHnhJc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62745	uniprotkb:Q9HCE7-2	intact:EBI-602647|uniprotkb:P01121|uniprotkb:Q5U0H6|uniprotkb:Q7RTN5|uniprotkb:Q7RTR9|uniprotkb:Q9CUV7|uniprotkb:B2R692|ensembl:ENSP00000272233	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:rhob_human(display_long)|uniprotkb:Rho cDNA clone 6(gene name synonym)|uniprotkb:RHOB(gene name)|psi-mi:RHOB(display_short)|uniprotkb:ARH6(gene name synonym)|uniprotkb:ARHB(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9846826|imex:IM-23200-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004031.1|ensembl:ENSG00000143878(gene)|ensembl:ENST00000272233(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001525"(angiogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010008"(endosome membrane)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P62745|rcsb pdb:2FV8|rcsb pdb:6HXU|rcsb pdb:6SGE|reactome:R-HSA-114604|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013026|interpro:IPR003578(Ras small GTPase, Rho type)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 2a, 2b, Suppl. Fig. 1c, 17, 18|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/10/13	2014/10/16	rogid:Ek7MCYtpm3JJ78E6nwU/Q9rWZmQ9606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:D79918FE61C1E33F|rigid:VIWMo/RNM604yZgwx4IzbPC6x1s	false	ha tag:?-?	sufficient binding region:1-159(IPR000008)|flag tag:?-?|mutation:699-699|sufficient binding region:346-731(IPR000569)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14757	uniprotkb:Q9HCE7-2	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9847056|imex:IM-23200-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	-	-	-	figure legend:Fig. 8c, Suppl. Fig. 18|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/10/13	2014/10/16	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	intact-crc:CB52C204252537AD|rigid:PvunxJU8Qs7Kl0GoAJ+eLIHnhJc	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14757	uniprotkb:Q9HCE7	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9847021|imex:IM-23200-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	-	-	-	figure legend:Fig. 8a, Suppl. Fig. 18|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/10/13	2014/10/16	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:B2A03A4505794340|rigid:V6A2BygYuYu+9Rcd2isbhgU7geQ	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HCE7-2	uniprotkb:O14757	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9847039|imex:IM-23200-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 8b, Suppl. Fig. 13b, 18|agonist:"ultraviolet (80 Jm-2)"|agonist:"methyl methanesulfonate (MMS) (CHEBI:25255) (0.5 mM)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/10/13	2014/10/16	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	intact-crc:F50A045E28EBB1ED|rigid:PvunxJU8Qs7Kl0GoAJ+eLIHnhJc	false	flag tag:?-?|mutation:699-699	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HCE7-2	uniprotkb:O14757	intact:EBI-9845742|ensembl:ENSP00000355326|ensembl:ENSP00000491036	intact:EBI-974488|ensembl:ENSP00000388648|ensembl:ENSP00000412504|ensembl:ENSP00000432890|ensembl:ENSP00000435371|ensembl:ENSP00000481616|uniprotkb:B4DDD0|uniprotkb:F5H7S4|uniprotkb:A8K934|uniprotkb:B4DSK3|uniprotkb:B5BTY6|uniprotkb:H2BI51	psi-mi:q9hce7-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)	psi-mi:chk1_human(display_long)|uniprotkb:CHEK1(gene name)|psi-mi:CHEK1(display_short)|uniprotkb:CHK1(gene name synonym)|uniprotkb:CHK1 checkpoint homolog(gene name synonym)|uniprotkb:Checkpoint kinase-1(gene name synonym)|uniprotkb:Cell cycle checkpoint kinase(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wang et al. (2014)	pubmed:25249323|imex:IM-23200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9847139|imex:IM-23200-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361368(transcript)|ensembl:ENST00000638461(transcript)|intact:EBI-976466(isoform-parent)|uniprotkb:Q9HCE7-2(isoform-parent)	ensembl:ENSG00000149554(gene)|ensembl:ENST00000428830(transcript)|ensembl:ENST00000438015(transcript)|ensembl:ENST00000524737(transcript)|ensembl:ENST00000532449(transcript)|ensembl:ENST00000534070(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010767"(regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035402"("histone kinase activity (H3-T11 specific)")|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0048096"|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090399"(replicative senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034670|mint:O14757|rcsb pdb:1IA8|rcsb pdb:1NVQ|rcsb pdb:1NVR|rcsb pdb:1NVS|rcsb pdb:1ZLT|rcsb pdb:1ZYS|rcsb pdb:2AYP|rcsb pdb:2BR1|rcsb pdb:2BRB|rcsb pdb:2BRG|rcsb pdb:2BRH|rcsb pdb:2BRM|rcsb pdb:2BRN|rcsb pdb:2BRO|rcsb pdb:2C3J|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|rcsb pdb:2C3K|rcsb pdb:2C3L|rcsb pdb:2CGU|rcsb pdb:2CGV|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006997"(nucleus organization)|rcsb pdb:2CGX|rcsb pdb:2E9N|rcsb pdb:2E9O|rcsb pdb:2E9P|rcsb pdb:2E9U|rcsb pdb:2E9V|rcsb pdb:2GDO|rcsb pdb:2GHG|rcsb pdb:2HOG|rcsb pdb:2HXL|rcsb pdb:2HXQ|rcsb pdb:2CGW|rcsb pdb:2HY0|rcsb pdb:2QHM|rcsb pdb:2QHN|rcsb pdb:2R0U|rcsb pdb:2WMQ|rcsb pdb:2WMR|rcsb pdb:2WMS|rcsb pdb:2WMT|rcsb pdb:2WMU|rcsb pdb:2YM7|rcsb pdb:2YM8|rcsb pdb:2YWP|rcsb pdb:3F9N|rcsb pdb:3JVR|rcsb pdb:3JVS|rcsb pdb:3NLB|rcsb pdb:3OT3|rcsb pdb:3OT8|rcsb pdb:3PA3|rcsb pdb:3PA4|rcsb pdb:2WMV|rcsb pdb:3PA5|rcsb pdb:3TKH|rcsb pdb:3TKI|rcsb pdb:2WMW|rcsb pdb:3U9N|rcsb pdb:4FSM|rcsb pdb:4FSN|rcsb pdb:2WMX|rcsb pdb:4FSQ|rcsb pdb:2X8D|rcsb pdb:2X8E|rcsb pdb:4FSR|rcsb pdb:4FST|rcsb pdb:4FSU|rcsb pdb:4FSW|rcsb pdb:4FSY|rcsb pdb:2X8I|rcsb pdb:2XEY|rcsb pdb:2XEZ|rcsb pdb:2XF0|rcsb pdb:2YDI|rcsb pdb:2YDJ|rcsb pdb:2YDK|rcsb pdb:2YER|rcsb pdb:2YEX|rcsb pdb:2YM3|rcsb pdb:2YM4|rcsb pdb:2YM5|rcsb pdb:2YM6|rcsb pdb:4FSZ|rcsb pdb:4FT0|rcsb pdb:4FT3|rcsb pdb:4FT5|rcsb pdb:4FT7|rcsb pdb:4FTA|rcsb pdb:4FTC|rcsb pdb:4FTI|rcsb pdb:4FTJ|rcsb pdb:4FTK|rcsb pdb:4FTL|rcsb pdb:4FTM|rcsb pdb:4FTN|rcsb pdb:4FTO|rcsb pdb:4FTQ|rcsb pdb:4FTR|rcsb pdb:4FTT|rcsb pdb:4FTU|rcsb pdb:4GH2|rcsb pdb:4FT9|rcsb pdb:4HYH|rcsb pdb:4HYI|rcsb pdb:4JIK|rcsb pdb:4QYE|rcsb pdb:4QYF|rcsb pdb:4QYG|rcsb pdb:4QYH|rcsb pdb:4RVK|rcsb pdb:4RVL|rcsb pdb:4RVM|rcsb pdb:5DLS|rcsb pdb:5F4N|rcsb pdb:5OOP|rcsb pdb:5OOR|rcsb pdb:5OOT|rcsb pdb:5OP2|rcsb pdb:5OP4|rcsb pdb:5OP5|rcsb pdb:5OP7|rcsb pdb:5OPB|rcsb pdb:5OPR|rcsb pdb:5OPS|rcsb pdb:5OPU|rcsb pdb:5OPV|rcsb pdb:5OQ5|rcsb pdb:5OQ6|rcsb pdb:5OQ7|rcsb pdb:5OQ8|rcsb pdb:5WI2|rcsb pdb:6FC8|rcsb pdb:6FCF|rcsb pdb:6FCK|rcsb pdb:7AKM|rcsb pdb:7AKO|rcsb pdb:7MCK|reactome:R-HSA-1433557|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-69601|reactome:R-HSA-75035|reactome:R-HSA-8953750|reactome:R-HSA-176187|refseq:NP_001107593.1|refseq:NP_001107594.1|refseq:NP_001265.2|refseq:NP_001231775.1|refseq:XP_016872635.1|refseq:NP_001317357.1|dip:DIP-24182N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 8e, 8f, Suppl. Fig. 14, 15, 18|caution:"Inconsistency between figure legend and methods section. Figure legend (8, suppl. 14) says HA-tagged Chk1 was immunoprecipitated from MMS-treated HeLa cells, while methods section says Flag-tagged Chk1 was immunoprecipitated from MMS-treated HEK293T cells. For this entry, annotation in the figure legends was followed."|resulting-ptm:Q9HCE7-2 thr-145 O-phospho-L-threonine|resulting-ptm:Q9HCE7-2  thr-161 O-phospho-L-threonine|resulting-ptm:Q9HCE7-2 thr-682 O-phospho-L-threonine|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/10/23	rogid:md1bcF3tLn6LDVaJAbCs5Yxk57w9606	rogid:S6QMFtpTWlBPrg6GN6b/1pgFCg09606	intact-crc:D87F44788B266495|rigid:PvunxJU8Qs7Kl0GoAJ+eLIHnhJc	false	glutathione s tranferase tag:n-n|mutation disrupting interaction rate:145-145,161-161,682-682	mutation disrupting interaction rate:130-130|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)