#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15455	uniprotkb:O15455	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Mineev et al. (2014)	imex:IM-23172|pubmed:25217833	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9694887|imex:IM-23172-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	-	-	-	figure legend:f1 f2 sfs|comment:we can conclude that TLR3-TM forms dimers and trimers of moderate stability in DPC micelles|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/28	2014/10/16	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	intact-crc:95CA79710306E752|rigid:xgReOxfYPEFNu2qbvsCQZBN2QsU	false	binding-associated region:698-730	binding-associated region:698-730	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15455	uniprotkb:O15455	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	intact:EBI-6116630|intact:EBI-6289595|uniprotkb:B2RAI7|uniprotkb:E6Y0F0|uniprotkb:E6Y0F1|uniprotkb:Q4VAL2|uniprotkb:Q504W0|uniprotkb:B7Z7K0|uniprotkb:E9PGH4|ensembl:ENSP00000296795	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:tlr3_human(display_long)|uniprotkb:TLR3(gene name)|psi-mi:TLR3(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Mineev et al. (2014)	imex:IM-23172|pubmed:25217833	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9694879|imex:IM-23172-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	refseq:NP_003256.1|refseq:XP_016864066.1|dip:DIP-29660N|ensembl:ENSG00000164342(gene)|ensembl:ENST00000296795(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009597"(detection of virus)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034346"(positive regulation of type III interferon production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035690"|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043331"(response to dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027173|interpro:IPR032675|interpro:IPR035897|interpro:IPR041015|mint:O15455|rcsb pdb:1ZIW|rcsb pdb:2A0Z|rcsb pdb:2MK9|rcsb pdb:2MKA|rcsb pdb:3ULU|rcsb pdb:3ULV|rcsb pdb:5GS0|rcsb pdb:7C76|reactome:R-HSA-1679131|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-5602410|reactome:R-HSA-5602415|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325	-	-	-	figure legend:f1 f2 sfs|comment:we can conclude that TLR3-TM forms dimers and trimers of moderate stability in DPC micelles|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/28	2014/10/16	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	rogid:SdJmbWAFiAY8Ki6UFhP2M1zREf09606	intact-crc:953FC934034312E2|rigid:xgReOxfYPEFNu2qbvsCQZBN2QsU	false	binding-associated region:698-730	binding-associated region:698-730	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)