#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53778	uniprotkb:P29074	intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659	intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7	psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym)	psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short)	psi-mi:"MI:0415"(enzymatic study)	Maisonneuve et al. (2014)	imex:IM-23056|pubmed:25158884	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9681788|imex:IM-23056-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221	refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N	-	-	-	figure legend:f1b t1|comment:"Both linker-PTP and PDZ-PTPWT dephosphorylated the pTyr substrate following  Michaelis-Menten kinetics (Fig. 1B). The Michaelis constant (KM) and the turnover number  (kcat) values were deduced by fitting the experimental data to the Michaelis-Menten equation  (Table 1). The kcat and KM values decreased by 6.5 fold and by 3.8 fold, respectively, when  comparing linker-PTP and PDZ-PTPWT. The compensatory effects between kcat and KM  explain the small change in the kcat/KM ratio of 1.7 fold (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:16.2x10^-6(molar)	2014/07/28	2014/10/16	rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606	rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606	intact-crc:2166FAF4DD564580|rigid:xZFj0z5VS/bg2EMl4UtHvQg3IXg	false	binding-associated region:178-189	glutathione s tranferase tag:?-?|binding-associated region:611-926	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29074	uniprotkb:P53778	intact:EBI-710431|ensembl:ENSP00000263708|uniprotkb:B2RBV8|uniprotkb:Q9UDA7	intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659	psi-mi:ptn4_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG1(gene name synonym)|uniprotkb:PTPN4(gene name)|psi-mi:PTPN4(display_short)	psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Maisonneuve et al. (2014)	imex:IM-23056|pubmed:25158884	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9681802|imex:IM-23056-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002821.1|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|rcsb pdb:2CS5|rcsb pdb:2I75|rcsb pdb:2VPH|rcsb pdb:3NFK|rcsb pdb:3NFL|rcsb pdb:5EYZ|rcsb pdb:5EZ0|reactome:R-HSA-166016|reactome:R-HSA-9008059|reactome:R-HSA-9022699|ensembl:ENSG00000088179(gene)|ensembl:ENST00000263708(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:XP_016860089.1|dip:DIP-34634N	refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221	-	-	-	figure legend:f1b t1|comment:"Both linker-PTP and PDZ-PTPWT dephosphorylated the pTyr substrate following  Michaelis-Menten kinetics (Fig. 1B). The Michaelis constant (KM) and the turnover number  (kcat) values were deduced by fitting the experimental data to the Michaelis-Menten equation  (Table 1). The kcat and KM values decreased by 6.5 fold and by 3.8 fold, respectively, when  comparing linker-PTP and PDZ-PTPWT. The compensatory effects between kcat and KM  explain the small change in the kcat/KM ratio of 1.7 fold (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2014/07/28	2014/10/16	rogid:o2XCVGiLiaTRa6iC4bbwOdzepQ89606	rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606	intact-crc:3F22948B8CD1B83C|rigid:xZFj0z5VS/bg2EMl4UtHvQg3IXg	false	glutathione s tranferase tag:?-?|binding-associated region:499-926	binding-associated region:178-189	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)