#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15559	uniprotkb:P15559	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lienhart et al. (2014)	pubmed:25143260|imex:IM-23062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9685543|imex:IM-23062-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:F3|comment:"The calculated size of  NQO1 (61 kDa) agrees well with the theoretical size of NQO1 dimers (62 kDa), on the other hand the  calculated size of NQO1 P187S (78.33 kDa) suggests that the hydrodynamic radius is larger compared to  that of NQO1."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/06	2014/10/16	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:66543220886A83D7|rigid:2YWDxCWOwc7KXSAFns8jUoV9mP0	false	mutation:187-187	mutation:187-187	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15559	uniprotkb:P15559	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lienhart et al. (2014)	pubmed:25143260|imex:IM-23062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9685555|imex:IM-23062-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:sf2 st1|comment:"These crystals  diffracted to 2.7 Å and revealed a structural topology (Fig. 2A) virtually identical to the NQO1 crystal  structure [15, 16] with a root-mean-square-deviation of 0.33 Å for 249 Cα atoms."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/06	2014/10/16	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:5688C08F11CF11C5|rigid:2YWDxCWOwc7KXSAFns8jUoV9mP0	false	mutation:187-187	mutation:187-187	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15559	uniprotkb:P15559	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lienhart et al. (2014)	pubmed:25143260|imex:IM-23062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9685561|imex:IM-23062-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:sf2 st1|comment:"These crystals  diffracted to 2.7 Å and revealed a structural topology (Fig. 2A) virtually identical to the NQO1 crystal  structure [15, 16] with a root-mean-square-deviation of 0.33 Å for 249 Cα atoms."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/06	2014/10/16	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:F93EA943757614DC|rigid:2YWDxCWOwc7KXSAFns8jUoV9mP0	false	mutation:187-187|binding-associated region:1-224	mutation:187-187|binding-associated region:1-224	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15559	uniprotkb:P15559	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lienhart et al. (2014)	pubmed:25143260|imex:IM-23062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9685575|imex:IM-23062-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:sf4|comment:"Analytical size exclusion chromatograms of purified NQO1 (continuous line) and NQO1 P187S (Dashed  line) obtained using a using a Superdex 200 (10/300) analytical column. The calculated molecular mass of  NQO1 (61.3 kDa) and NQO1 P187S (78.33 kDa) indicate that both the proteins exist in dimeric forms.  The lower elution volume observed for NQO1 P187S indicates that deviation from the globular structure  adopted by NQO1, thus supporting our NMR data that the P187S variant exhibits a more disordered  structure compared to that of NQO1"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/06	2014/10/16	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:F41D3A7B89C8CFD3|rigid:2YWDxCWOwc7KXSAFns8jUoV9mP0	false	mutation:187-187	mutation:187-187	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15559	uniprotkb:P15559	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	intact:EBI-3989435|uniprotkb:B2R5Y9|uniprotkb:Q86UK1|ensembl:ENSP00000319788|uniprotkb:B7ZAD1|uniprotkb:B4DNM7	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:nqo1_human(display_long)|uniprotkb:NQO1(gene name)|psi-mi:NQO1(display_short)|uniprotkb:DIA4(gene name synonym)|uniprotkb:NMOR1(gene name synonym)|uniprotkb:Azoreductase(gene name synonym)|uniprotkb:DT-diaphorase(gene name synonym)|uniprotkb:Menadione reductase(gene name synonym)|uniprotkb:"NAD(P)H:quinone oxidoreductase 1"(gene name synonym)|uniprotkb:Phylloquinone reductase(gene name synonym)|uniprotkb:Quinone reductase 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lienhart et al. (2014)	pubmed:25143260|imex:IM-23062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9685585|imex:IM-23062-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	refseq:NP_000894.1|refseq:NP_001020604.1|ensembl:ENSG00000181019(gene)|ensembl:ENST00000320623(transcript)|reactome:R-HSA-350562|go:"GO:0003723"(RNA binding)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006116"(NADH oxidation)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008753"("NADPH dehydrogenase (quinone) activity")|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0014075"(response to amine)|go:"GO:0030425"(dendrite)|go:"GO:0032355"(response to estradiol)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0002931"(response to ischemia)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045471"(response to ethanol)|go:"GO:0050136"("NADH dehydrogenase (quinone) activity")|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1904844"(response to L-glutamine)|go:"GO:1904880"(response to hydrogen sulfide)|go:"GO:1905395"(response to flavonoid)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|mint:P15559|rcsb pdb:1D4A|rcsb pdb:1DXO|rcsb pdb:1GG5|rcsb pdb:1H66|rcsb pdb:1H69|rcsb pdb:1KBO|rcsb pdb:1KBQ|rcsb pdb:1QBG|rcsb pdb:2F1O|rcsb pdb:3JSX|rcsb pdb:4CET|rcsb pdb:4CF6|rcsb pdb:5A4K|rcsb pdb:5EA2|rcsb pdb:5EAI|rcsb pdb:5FUQ|rcsb pdb:6FY4|rcsb pdb:6LLC|refseq:NP_001020605.1|dip:DIP-24210N	-	-	-	figure legend:sf4|comment:"Analytical size exclusion chromatograms of purified NQO1 (continuous line) and NQO1 P187S (Dashed  line) obtained using a using a Superdex 200 (10/300) analytical column. The calculated molecular mass of  NQO1 (61.3 kDa) and NQO1 P187S (78.33 kDa) indicate that both the proteins exist in dimeric forms.  The lower elution volume observed for NQO1 P187S indicates that deviation from the globular structure  adopted by NQO1, thus supporting our NMR data that the P187S variant exhibits a more disordered  structure compared to that of NQO1"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/08/06	2014/10/16	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	rogid:FTxQttmBGSHV/ICU3eacckUXQ7s9606	intact-crc:16C230ADFE50BD44|rigid:2YWDxCWOwc7KXSAFns8jUoV9mP0	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)