#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P28300 uniprotkb:Q8WXI9 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872287|imex:IM-23221-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 intact-crc:986BE7A46BE82CB9|rigid:HWyOqh6LoVnFUsul5Pi60wl5AE8 false sufficient binding region:169-417|gal4 dna binding domain:n-n sufficient binding region:334-593|experimental feature:n-n - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y316 uniprotkb:P28300 intact:EBI-1104564|uniprotkb:Q5R2V9|uniprotkb:Q6NSL5|uniprotkb:D6W575|uniprotkb:B4DLS0|uniprotkb:Q5R2V8|ensembl:ENSP00000385557|ensembl:ENSP00000295065 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 psi-mi:memo1_human(display_long)|uniprotkb:MEMO1(gene name)|psi-mi:MEMO1(display_short)|uniprotkb:CGI-27(orf name)|uniprotkb:Mediator of ErbB2-driven cell motility 1(gene name synonym)|uniprotkb:C2orf4(gene name synonym)|uniprotkb:NS5ATP7(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 7(gene name synonym)|uniprotkb:C21orf19-like protein(gene name synonym)|uniprotkb:MEMO(gene name synonym) psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872299|imex:IM-23221-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001288762.1|refseq:NP_001288781.1|refseq:NP_001131074.1|refseq:NP_057039.1|refseq:XP_011531194.1|refseq:XP_016859744.1|ensembl:ENST00000295065(transcript)|ensembl:ENST00000404530(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0032886"(regulation of microtubule-based process)|interpro:IPR002737(Protein of unknown function DUF52)|rcsb pdb:3BCZ|rcsb pdb:3BD0|reactome:R-HSA-6785631|ensembl:ENSG00000162959(gene) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:RL1cWMim2S2Bu+BTlRkdTHnJLxg9606 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 intact-crc:47B4C8306F9CC110|rigid:jGzvPGGlJuIce5p8DsDjQTQUkIU false experimental feature:n-n|sufficient binding region:13-145 sufficient binding region:169-417|gal4 dna binding domain:n-n - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14676 uniprotkb:P28300 intact:EBI-495644|uniprotkb:A2AB04|uniprotkb:A2BF04|uniprotkb:A2RRA8|uniprotkb:A7YY86|uniprotkb:B0S8A2|uniprotkb:Q0EFC2|uniprotkb:Q2L6H7|uniprotkb:Q2TAZ4|uniprotkb:Q5ST83|uniprotkb:Q68CQ3|uniprotkb:Q86Z06|uniprotkb:Q96QC2|uniprotkb:Q5JP55|uniprotkb:Q5JP56|ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000387429|ensembl:ENSP00000396484|ensembl:ENSP00000404318|ensembl:ENSP00000409167|ensembl:ENSP00000415212|ensembl:ENSP00000416511|intact:EBI-28978228 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 psi-mi:mdc1_human(display_long)|uniprotkb:Nuclear factor with BRCT domains 1(gene name synonym)|uniprotkb:MDC1(gene name)|psi-mi:MDC1(display_short)|uniprotkb:KIAA0170(gene name synonym)|uniprotkb:NFBD1(gene name synonym) psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872324|imex:IM-23221-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000365588|ensembl:ENSP00000373060|ensembl:ENSP00000396484|ensembl:ENSP00000416511|ensembl:ENSP00000387429|ensembl:ENSP00000404318|ensembl:ENSP00000415212|ensembl:ENSP00000409167|refseq:NP_055456.2|refseq:XP_011513303.1|refseq:XP_011513305.1|refseq:XP_005249551.1|dip:DIP-33603N|refseq:XP_016867008.1|ensembl:ENSG00000137337(gene)|ensembl:ENSG00000206481(gene)|ensembl:ENSG00000225589(gene)|ensembl:ENSG00000228575(gene)|ensembl:ENSG00000231135(gene)|ensembl:ENSG00000234012(gene)|ensembl:ENSG00000237095(gene)|ensembl:ENST00000376406(transcript)|ensembl:ENST00000383566(transcript)|ensembl:ENST00000420019(transcript)|ensembl:ENST00000420320(transcript)|ensembl:ENST00000427406(transcript)|ensembl:ENSG00000224587(gene)|ensembl:ENST00000435664(transcript)|ensembl:ENST00000440369(transcript)|ensembl:ENST00000449153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006281"(DNA repair)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0070975"(FHA domain binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001357(BRCT)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR036420|mint:Q14676|rcsb pdb:2ADO|rcsb pdb:2AZM|rcsb pdb:2ETX|rcsb pdb:3K05|rcsb pdb:3UEO|rcsb pdb:3UMZ|rcsb pdb:3UN0|rcsb pdb:3UNM|rcsb pdb:3UNN|rcsb pdb:3UOT|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-6796648|reactome:R-HSA-69473 refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:fkclTpFKHkxAjNuMuTmZRAigCa89606 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 intact-crc:F01EA5B0B5AB4FF2|rigid:uvEuNzvn/6t0L7VEOmfqDXjrz+A false sufficient binding region:1974-2089|experimental feature:n-n sufficient binding region:169-417|gal4 dna binding domain:n-n - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P28300 uniprotkb:Q07890 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 intact:EBI-298181|uniprotkb:Q15503|uniprotkb:D3DSB4|intact:EBI-28974690|uniprotkb:Q17RN1|ensembl:ENSP00000216373|uniprotkb:B7ZKT6 psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:sos2_human(display_long)|uniprotkb:SOS2(gene name)|psi-mi:SOS2(display_short) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872360|imex:IM-23221-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) ensembl:ENSP00000216373|ensembl:ENST00000543680|ensembl:ENSP00000445328|refseq:NP_008870.2|ensembl:ENSG00000100485(gene)|ensembl:ENST00000216373(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:6EIE|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-8983432|reactome:R-HSA-9013149|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25) - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rogid:CZsyrWgbgewhJ8ENDzpVNhtpKJU9606 intact-crc:7A69643B33EDC856|rigid:DZwg4HJyJxapwBTuxc2OM7gshbU false sufficient binding region:169-417|gal4 dna binding domain:n-n experimental feature:n-n|sufficient binding region:1169-1248 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UQ80 uniprotkb:P28300 intact:EBI-924893|uniprotkb:Q9UM59|uniprotkb:O43846|ensembl:ENSP00000302886 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 psi-mi:pa2g4_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)|uniprotkb:Cell cycle protein p38-2G4 homolog(gene name synonym)|uniprotkb:ErbB3-binding protein 1(gene name synonym)|uniprotkb:EBP1(gene name synonym) psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872411|imex:IM-23221-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006182.2|dip:DIP-31275N|ensembl:ENSG00000170515(gene)|ensembl:ENST00000303305(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:Q9UQ80|rcsb pdb:2Q8K|rcsb pdb:3J2I|rcsb pdb:6CHT|rcsb pdb:6LSR|rcsb pdb:6SXO|rcsb pdb:6WM8|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-6798695|interpro:IPR018349 refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) - - - figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:OGRaz1uHilOnGXaAr/yeKMlCyns9606 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 intact-crc:ED02F6701DA4B980|rigid:Tnx0YYGKQAd99pJ0M7baOgTT/8M false experimental feature:n-n|sufficient binding region:238-373,184-318 sufficient binding region:169-417|gal4 dna binding domain:n-n - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8WXI9 uniprotkb:P28301 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247 psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym) psi-mi:"MI:0096"(pull down) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872521|imex:IM-23221-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919 - - - figure legend:Figure 1B, Figure 1D, Figure S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/20 2014/10/28 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090 intact-crc:11914608632E415C|rigid:A/UJOdnp1mHO7So/WYBp6JqxSoY false green fluorescent protein tag:n-n|sufficient binding region:339-593 sufficient binding region:163-411|his tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q08397 uniprotkb:Q8WXI9 intact:EBI-5395846|uniprotkb:Q6NUL3|uniprotkb:Q96BW7|ensembl:ENSP00000261921 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 psi-mi:loxl1_human(display_long)|uniprotkb:LOXL1(gene name)|psi-mi:LOXL1(display_short)|uniprotkb:LOXL(gene name synonym)|uniprotkb:Lysyl oxidase-like protein 1(gene name synonym) psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:"MI:0096"(pull down) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872584|imex:IM-23221-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005567.2|ensembl:ENSG00000129038(gene)|ensembl:ENST00000261921(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018277"(protein deamination)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035904"(aorta development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|reactome:R-HSA-1566948|reactome:R-HSA-2243919 refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 - - - figure legend:Figure S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/20 2014/10/28 rogid:JH05ghJNnvJeMUhA3j+L9jOqr3g9606 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 intact-crc:53B37F23DC2EA520|rigid:BeLKgrlnR36Xjhf6X5GZrnnXQuY false his tag:n-n|sufficient binding region:370-574 green fluorescent protein tag:n-n|sufficient binding region:1-593 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WXI9 uniprotkb:P58215 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 intact:EBI-723960|ensembl:ENSP00000264094|uniprotkb:Q96RS1|uniprotkb:D6W5J1|uniprotkb:Q2EHP2|uniprotkb:Q6IPL7 psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:loxl3_human(display_long)|uniprotkb:Lysyl oxidase-like protein 3(gene name synonym)|uniprotkb:LOXL3(gene name)|psi-mi:LOXL3(display_short)|uniprotkb:LOXL(gene name synonym) psi-mi:"MI:0096"(pull down) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9872597|imex:IM-23221-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 refseq:NP_115992.1|ensembl:ENSG00000115318(gene)|ensembl:ENST00000264094(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0021510"(spinal cord development)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030324"(lung development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061053"(somite development)|go:"GO:1905590"(fibronectin fibril organization)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR019828|interpro:IPR036772|reactome:R-HSA-1566948|go:"GO:0001837"(epithelial to mesenchymal transition)|reactome:R-HSA-2243919|go:"GO:0001968"(fibronectin binding)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|refseq:XP_011531436.1|refseq:NP_001276094.1|refseq:NP_001276093.1|refseq:XP_016860601.1 - - - figure legend:Figure S2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/10/20 2014/10/28 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 rogid:ZemGKB4zxFQQW1MbA4fiP/NX7ow9606 intact-crc:F2E0A3BCCAFF7AEB|rigid:U5dpq8J6UIbXfxVbuoZAGjg2ZJU false sufficient binding region:1-593|green fluorescent protein tag:n-n his tag:n-n|sufficient binding region:530-753 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P28300 uniprotkb:Q9UBX5 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 intact:EBI-947897|uniprotkb:O75966|uniprotkb:Q6UWA3|uniprotkb:Q6IAL4|ensembl:ENSP00000345008 psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:fbln5_human(display_long)|uniprotkb:Developmental arteries and neural crest EGF-like protein(gene name synonym)|uniprotkb:Urine p50 protein(gene name synonym)|uniprotkb:FBLN5(gene name)|psi-mi:FBLN5(display_short)|uniprotkb:DANCE(gene name synonym)|uniprotkb:UNQ184/PRO210(orf name) psi-mi:"MI:0018"(two hybrid) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-9874347|imex:IM-23221-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) refseq:NP_006320.2|dip:DIP-44301N|ensembl:ENSG00000140092(gene)|ensembl:ENST00000342058(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046903"(secretion)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR037288|mint:Q9UBX5|reactome:R-HSA-1566948|reactome:R-HSA-2129379 - - - figure legend:Figure S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2014/10/20 2018/08/28 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rogid:1fqx+PBkfO9F1/5wXcNasL9R8Mk9606 intact-crc:9872FE289BF3969C|rigid:5rvwSh/Mczd9fxAPkTPVljHHl44 false gal4 dna binding domain:n-n|sufficient binding region:169-417 sufficient binding region:310-376|experimental feature:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28300 uniprotkb:Q8WXI9 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0917"(matrixdb) intact:EBI-9874370|imex:IM-23221-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 go:"GO:0005634"(nucleus) - - figure legend:Figure 2, Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/10/20 2018/08/28 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 intact-crc:53644F9F4E7C15B9|rigid:HWyOqh6LoVnFUsul5Pi60wl5AE8 false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P28300 uniprotkb:Q8WXI9 intact:EBI-3893481|uniprotkb:B2R5Q3|uniprotkb:Q5FWF0|ensembl:ENSP00000231004 intact:EBI-923440|uniprotkb:Q5VUR2|uniprotkb:Q7LG68|uniprotkb:Q9ULS0|uniprotkb:D3DUZ2|ensembl:ENSP00000357644|ensembl:ENSP00000458280|ensembl:ENSP00000489184 psi-mi:lyox_human(display_long)|uniprotkb:LOX(gene name)|psi-mi:LOX(display_short)|uniprotkb:Lysyl oxidase(gene name synonym) psi-mi:p66b_human(display_long)|uniprotkb:GATAD2B(gene name)|psi-mi:GATAD2B(display_short)|uniprotkb:KIAA1150(gene name synonym)|uniprotkb:p66/p68(gene name synonym)|uniprotkb:GATA zinc finger domain-containing protein 2B(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Okkelman et al. (2014) pubmed:25118846|imex:IM-23221 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0917"(matrixdb) intact:EBI-9874390|imex:IM-23221-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002308.2|dip:DIP-49007N|ensembl:ENSG00000113083(gene)|ensembl:ENST00000231004(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|interpro:IPR019828|mint:P28300|reactome:R-HSA-1566948|reactome:R-HSA-2243919|go:"GO:0046716"(muscle cell cellular homeostasis) refseq:NP_065750.1|refseq:XP_005245421.1|dip:DIP-36054N|ensembl:ENSG00000143614(gene)|ensembl:ENSG00000261992(gene)|ensembl:ENST00000368655(transcript)|ensembl:ENST00000576342(transcript)|ensembl:ENST00000634544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR032346|interpro:IPR040386|mint:Q8WXI9|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191 go:"GO:0005634"(nucleus) - - figure legend:Figure 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mcf7)|taxid:9606(Homo sapiens mammary carcinoma cells) - 2014/10/20 2018/08/28 rogid:bDUlKQ5akDOhya4GydJ+PaLs7Fo9606 rogid:pLKkMcJBBWdyMTf+2axWzvZLKP09606 intact-crc:E24CE4C5F78C2956|rigid:HWyOqh6LoVnFUsul5Pi60wl5AE8 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)