#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y6D0	uniprotkb:Q9Y6D0	intact:EBI-9679163|uniprotkb:Q8IZQ3|uniprotkb:Q9P085|ensembl:ENSP00000418813	intact:EBI-9679163|uniprotkb:Q8IZQ3|uniprotkb:Q9P085|ensembl:ENSP00000418813	psi-mi:selk_human(display_long)|uniprotkb:SELENOK(gene name)|psi-mi:SELENOK(display_short)|uniprotkb:SELK(gene name synonym)|uniprotkb:HSPC030(orf name)|uniprotkb:HSPC297(orf name)	psi-mi:selk_human(display_long)|uniprotkb:SELENOK(gene name)|psi-mi:SELENOK(display_short)|uniprotkb:SELK(gene name synonym)|uniprotkb:HSPC030(orf name)|uniprotkb:HSPC297(orf name)	psi-mi:"MI:0943"(detection by mass spectrometry)	Liu et al. (2014)	imex:IM-23055|pubmed:25117454	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9679183|imex:IM-23055-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067060.2|ensembl:ENSG00000113811(gene)|ensembl:ENST00000495461(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR024491|rcsb pdb:6DO3	refseq:NP_067060.2|ensembl:ENSG00000113811(gene)|ensembl:ENST00000495461(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR024491|rcsb pdb:6DO3	-	-	-	figure legend:f2b|comment:"Furthermore, when examined by electrospray mass  spectrometry, SelK U92 ionized as a dimer under non-reducing conditions (Fig. 2B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:e0SoDHprfiTOiInNeRHt0mWfPWU9606	rogid:e0SoDHprfiTOiInNeRHt0mWfPWU9606	intact-crc:8F0C9FBC60CD0BF1|rigid:LjPXB4cfePhRf89QZKdgF/xsBTY	false	strep tag:?-?	strep tag:?-?	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6D0	uniprotkb:Q9Y6D0	intact:EBI-9679163|uniprotkb:Q8IZQ3|uniprotkb:Q9P085|ensembl:ENSP00000418813	intact:EBI-9679163|uniprotkb:Q8IZQ3|uniprotkb:Q9P085|ensembl:ENSP00000418813	psi-mi:selk_human(display_long)|uniprotkb:SELENOK(gene name)|psi-mi:SELENOK(display_short)|uniprotkb:SELK(gene name synonym)|uniprotkb:HSPC030(orf name)|uniprotkb:HSPC297(orf name)	psi-mi:selk_human(display_long)|uniprotkb:SELENOK(gene name)|psi-mi:SELENOK(display_short)|uniprotkb:SELK(gene name synonym)|uniprotkb:HSPC030(orf name)|uniprotkb:HSPC297(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Liu et al. (2014)	imex:IM-23055|pubmed:25117454	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9679224|imex:IM-23055-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067060.2|ensembl:ENSG00000113811(gene)|ensembl:ENST00000495461(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR024491|rcsb pdb:6DO3	refseq:NP_067060.2|ensembl:ENSG00000113811(gene)|ensembl:ENST00000495461(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR024491|rcsb pdb:6DO3	-	-	-	figure legend:f2a sf1|comment:"As can be observed from a SDS-PAGE run under non-reducing conditions (Fig.  2A), SelK U92 migrated as a dimer of 23 kDa, SelK U92C migrated mostly as a dimer, and SelK  U92S migrated mostly as a monomer. All three proteins migrated as a monomer of 11.5 kDa  under reducing conditions."|comment:"The  dimerization is not exclusively dependent on the presence of a diselenide bond since SelK U92S,  which has no intermolecular bond, can run as both a monomer and dimer on denaturing  SDS-PAGE when its concentration is sufficiently high (Supplementary data, Fig. S1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/23	2014/10/16	rogid:e0SoDHprfiTOiInNeRHt0mWfPWU9606	rogid:e0SoDHprfiTOiInNeRHt0mWfPWU9606	intact-crc:F81D1EF30E4C0422|rigid:LjPXB4cfePhRf89QZKdgF/xsBTY	false	strep tag:?-?|mutation disrupting interaction:92-92	strep tag:?-?|mutation disrupting interaction:92-92	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)