#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H8V3	uniprotkb:Q9H0H5	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663296|imex:IM-23072-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	-	-	-	figure legend:sf6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:52.0x10^-6(molar)	2014/07/16	2014/10/16	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	intact-crc:119627A5152E32B5|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	binding-associated region:22-326	phosphorylated residue:164-164,157-157|binding-associated region:151-172	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H8V3	uniprotkb:Q9H0H5	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663315|imex:IM-23072-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	-	-	-	figure legend:f3c f4a f4b sf6|comment:"After two long peptides were tested, we found that peptide  pS157long exhibits no binding to ECT2 (22-326) and peptide pS157/pS164 have  similar binding ability as peptide pS164 ((Kd =43.1±13.6 μM) (Fig S6), which  suggests that pS157 can not interact with ECT2 even if W167 is accompanied."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:42.0x10^-6(molar)	2014/07/16	2014/10/16	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	intact-crc:656D198924A34E2A|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	binding-associated region:22-326	binding-associated region:157-171|phosphorylated residue:164-164	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H0H5	uniprotkb:Q9H8V3	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663264|imex:IM-23072-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	-	-	-	figure legend:st2 f3c f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:187.0x10^-6(molar)	2014/07/16	2014/10/16	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	intact-crc:E7E22AD39ECF80B3|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	phosphorylated residue:164-164|binding-associated region:157-171	mutation decreasing interaction:163-163|binding-associated region:22-326	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H8V3	uniprotkb:Q9H0H5	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663232|imex:IM-23072-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	-	-	-	figure legend:st2 f3c f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/16	2014/10/16	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	intact-crc:BCC6F27FAFC057F4|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	binding-associated region:22-326|mutation disrupting interaction:153-153,195-195	phosphorylated residue:164-164|binding-associated region:157-171	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H8V3	uniprotkb:Q9H0H5	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663099|imex:IM-23072-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	-	-	-	figure legend:st2 f3c f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/16	2014/10/16	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	intact-crc:B65D5E9933D461B3|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	mutation decreasing interaction:153-153|binding-associated region:22-326	binding-associated region:157-171|phosphorylated residue:164-164	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H0H5	uniprotkb:Q9H8V3	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663248|imex:IM-23072-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	-	-	-	figure legend:st2 f3c f4a f4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/07/16	2014/10/16	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	intact-crc:073B39ABB141D01E|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	phosphorylated residue:164-164|binding-associated region:157-171	binding-associated region:22-326|mutation disrupting interaction:195-195	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H0H5	uniprotkb:Q9H8V3	intact:EBI-717233|uniprotkb:Q6PJ26|uniprotkb:Q9NWN2|uniprotkb:Q9P250|uniprotkb:Q9P2W2|ensembl:ENSP00000309871|ensembl:ENSP00000404190|ensembl:ENSP00000404808|ensembl:ENSP00000449370|ensembl:ENSP00000449374	intact:EBI-1054039|uniprotkb:Q9NSV8|uniprotkb:Q9NVW9|uniprotkb:Q0MT80|uniprotkb:Q6U836|uniprotkb:Q2M269|ensembl:ENSP00000376457	psi-mi:rgap1_human(display_long)|uniprotkb:Male germ cell RacGap(gene name synonym)|uniprotkb:RACGAP1(gene name)|psi-mi:RACGAP1(display_short)|uniprotkb:KIAA1478(gene name synonym)|uniprotkb:MGCRACGAP(gene name synonym)|uniprotkb:Protein CYK4 homolog(gene name synonym)	psi-mi:ect2_human(display_long)|uniprotkb:Epithelial cell-transforming sequence 2 oncogene(gene name synonym)|uniprotkb:ECT2(gene name)|psi-mi:ECT2(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Zou et al. (2014)	imex:IM-23072|pubmed:25068414	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9663279|imex:IM-23072-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119575.1|refseq:NP_001119576.1|refseq:NP_037409.2|refseq:NP_001306928.1|refseq:NP_001306929.1|refseq:NP_001306930.1|refseq:NP_001306931.1|refseq:NP_001306932.1|refseq:NP_001306933.1|refseq:NP_001306934.1|refseq:NP_001306935.1|refseq:NP_001306936.1|refseq:XP_011536540.1|refseq:XP_006719422.1|refseq:XP_016874709.1|ensembl:ENSG00000161800(gene)|ensembl:ENST00000312377(transcript)|ensembl:ENST00000427314(transcript)|ensembl:ENST00000454520(transcript)|ensembl:ENST00000547905(transcript)|ensembl:ENST00000551016(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008272"(sulfate transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|go:"GO:0097149"(centralspindlin complex)|interpro:IPR000198(RhoGAP)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008936(Rho GTPase activation protein)|mint:Q9H0H5|rcsb pdb:2OVJ|rcsb pdb:3W6R|rcsb pdb:3WPQ|rcsb pdb:3WPS|rcsb pdb:4B6D|rcsb pdb:5C2J|rcsb pdb:5C2K|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013423|reactome:R-HSA-983189|dip:DIP-33087N	refseq:XP_011510816.1|refseq:NP_060568.3|refseq:NP_001245244.1|refseq:NP_001245245.1|ensembl:ENSG00000114346(gene)|ensembl:ENST00000392692(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007399"(nervous system development)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097149"(centralspindlin complex)|go:"GO:2000431"(regulation of cytokinesis, actomyosin contractile ring assembly)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001357(BRCT)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036420|mint:Q9H8V3|rcsb pdb:3L46|rcsb pdb:4N40|rcsb pdb:6L30|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|interpro:IPR026817|interpro:IPR035899|dip:DIP-47496N	-	-	-	figure legend:f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:800.0x10^-6(molar)	2014/07/16	2014/10/16	rogid:cjlAuqAG2p8cju3iMfySUeETiAU9606	rogid:ApqtJWU8n3b+PM8yUysFwFOkWuk9606	intact-crc:A189F9F02E3B970E|rigid:2its6d2tlXP61UpBgv1BdrtQSHQ	false	phosphorylated residue:164-164|binding-associated region:157-171|mutation decreasing interaction:167-167	binding-associated region:22-326	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)